(data stored in SCRATCH zone)

SWISSPROT: NHAP2_PSEU2

ID   NHAP2_PSEU2             Reviewed;         580 AA.
AC   Q4ZZ50;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 2.
DT   11-DEC-2019, entry version 91.
DE   RecName: Full=K(+)/H(+) antiporter NhaP2 {ECO:0000255|HAMAP-Rule:MF_01075};
DE   AltName: Full=Potassium/proton antiporter NhaP2 {ECO:0000255|HAMAP-Rule:MF_01075};
GN   Name=nhaP2 {ECO:0000255|HAMAP-Rule:MF_01075}; Synonyms=cvrA;
GN   OrderedLocusNames=Psyr_0502;
OS   Pseudomonas syringae pv. syringae (strain B728a).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas; Pseudomonas syringae.
OX   NCBI_TaxID=205918;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B728a;
RX   PubMed=16043691; DOI=10.1073/pnas.0504930102;
RA   Feil H., Feil W.S., Chain P., Larimer F., Dibartolo G., Copeland A.,
RA   Lykidis A., Trong S., Nolan M., Goltsman E., Thiel J., Malfatti S.,
RA   Loper J.E., Lapidus A., Detter J.C., Land M., Richardson P.M.,
RA   Kyrpides N.C., Ivanova N., Lindow S.E.;
RT   "Comparison of the complete genome sequences of Pseudomonas syringae pv.
RT   syringae B728a and pv. tomato DC3000.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:11064-11069(2005).
CC   -!- FUNCTION: K(+)/H(+) antiporter that extrudes potassium in exchange for
CC       external protons and maintains the internal concentration of potassium
CC       under toxic levels. {ECO:0000255|HAMAP-Rule:MF_01075}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01075}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01075}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC       transporter (TC 2.A.36) family. NhaP2 subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_01075}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAY35572.1; Type=Erroneous initiation; Evidence={ECO:0000305};
DR   EMBL; CP000075; AAY35572.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_003414375.1; NC_007005.1.
DR   RefSeq; YP_233610.2; NC_007005.1.
DR   STRING; 205918.Psyr_0502; -.
DR   EnsemblBacteria; AAY35572; AAY35572; Psyr_0502.
DR   GeneID; 3365978; -.
DR   KEGG; psb:Psyr_0502; -.
DR   PATRIC; fig|205918.7.peg.521; -.
DR   eggNOG; ENOG4105C3N; Bacteria.
DR   eggNOG; COG3263; LUCA.
DR   HOGENOM; HOG000019567; -.
DR   KO; K11105; -.
DR   BioCyc; PSYR205918:G1G4J-503-MONOMER; -.
DR   Proteomes; UP000000426; Chromosome.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0015386; F:potassium:proton antiporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006884; P:cell volume homeostasis; IEA:InterPro.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   Gene3D; 3.30.465.10; -; 1.
DR   Gene3D; 3.30.70.1450; -; 1.
DR   HAMAP; MF_01075; NhaP2; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR   InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   InterPro; IPR030151; NhaP.
DR   InterPro; IPR023729; NhaP2.
DR   InterPro; IPR006037; RCK_C.
DR   InterPro; IPR036721; RCK_C_sf.
DR   InterPro; IPR005170; Transptr-assoc_dom.
DR   PANTHER; PTHR32507:SF7; PTHR32507:SF7; 1.
DR   Pfam; PF03471; CorC_HlyC; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   Pfam; PF02080; TrkA_C; 1.
DR   SMART; SM01091; CorC_HlyC; 1.
DR   SUPFAM; SSF116726; SSF116726; 1.
DR   SUPFAM; SSF56176; SSF56176; 1.
DR   PROSITE; PS51202; RCK_C; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q4ZZ50.
DR   SWISS-2DPAGE; Q4ZZ50.
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Potassium; Potassium transport; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..580
FT                   /note="K(+)/H(+) antiporter NhaP2"
FT                   /id="PRO_0000052394"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01075"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01075"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01075"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01075"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01075"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01075"
FT   TRANSMEM        189..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01075"
FT   TRANSMEM        217..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01075"
FT   TRANSMEM        240..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01075"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01075"
FT   TRANSMEM        302..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01075"
FT   TRANSMEM        334..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01075"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01075"
FT   DOMAIN          402..484
FT                   /note="RCK C-terminal"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01075"
SQ   SEQUENCE   580 AA;  61468 MW;  94D43DB7B0D29840 CRC64;
     MDATTINSLF LIGALLVAAS ILVSSLSSRL GIPILVIILA VGMVAGVDGG GIIFDNYATA
     YLVGNLALAV ILLDGGLRTR VASFRVALWP ALSLATVGVL ITTVLTGMMA AWLFNLSVIQ
     GLLIGAIVGS TDAAAVFSLL GGKGLNERVT ASLEIESGSN DPMAVFLTVT LIGMLASGQT
     GLHWGLLGHL IQEFGIGSFI GLGGGWILLQ LVNRINLAAG LYPILVIAGG LAIFALTNAI
     HGSGFLAVYL CGLVLGNRPI RSRHGILHML DGMAWLAQIG MFLVLGLLVT PHDLLPIAIP
     ALGLALWMIL VARPLSVMVG LLPFKAFHDR EKAFIAWVGL RGAVPIILAV FPLMAGLPNA
     QLYFNLAFFI VLVSLLLQGT SLPWMAKLLK VTVPPDPAPI SRAALEVHVT SEWELFVYRL
     GAEKWCIGAA LRELKMPEGT RIAALFRGQQ LLHPSGSTTL EVGDLLCVIG HEHDLPALGK
     LFSQAPQRGL DLRFFGDFVL EGDARLGEVA ALYGLKLDGI DPGMPLSQFI VQKNRGEPVV
     GDQVEWNGTI WTVAVMDGNK IQKVGVKFPE GTRPGPGLFL
//

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