(data stored in ACNUC7421 zone)

SWISSPROT: Q4ZZ45_PSEU2

ID   Q4ZZ45_PSEU2            Unreviewed;       519 AA.
AC   Q4ZZ45;
DT   07-JUN-2005, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2005, sequence version 1.
DT   08-MAY-2019, entry version 98.
DE   RecName: Full=Sodium/proline symporter {ECO:0000256|RuleBase:RU366012};
DE   AltName: Full=Proline permease {ECO:0000256|RuleBase:RU366012};
GN   OrderedLocusNames=Psyr_0507 {ECO:0000313|EMBL:AAY35577.1};
OS   Pseudomonas syringae pv. syringae (strain B728a).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas; Pseudomonas syringae.
OX   NCBI_TaxID=205918 {ECO:0000313|EMBL:AAY35577.1, ECO:0000313|Proteomes:UP000000426};
RN   [1] {ECO:0000313|EMBL:AAY35577.1, ECO:0000313|Proteomes:UP000000426}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B728a {ECO:0000313|EMBL:AAY35577.1,
RC   ECO:0000313|Proteomes:UP000000426};
RX   PubMed=16043691; DOI=10.1073/pnas.0504930102;
RA   Feil H., Feil W.S., Chain P., Larimer F., Dibartolo G., Copeland A.,
RA   Lykidis A., Trong S., Nolan M., Goltsman E., Thiel J., Malfatti S.,
RA   Loper J.E., Lapidus A., Detter J.C., Land M., Richardson P.M.,
RA   Kyrpides N.C., Ivanova N., Lindow S.E.;
RT   "Comparison of the complete genome sequences of Pseudomonas syringae
RT   pv. syringae B728a and pv. tomato DC3000.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:11064-11069(2005).
CC   -!- FUNCTION: Catalyzes the sodium-dependent uptake of extracellular
CC       L-proline. {ECO:0000256|RuleBase:RU366012}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|RuleBase:RU366012}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU366012}.
CC   -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF)
CC       (TC 2.A.21) family. {ECO:0000256|RuleBase:RU366012}.
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DR   EMBL; CP000075; AAY35577.1; -; Genomic_DNA.
DR   RefSeq; WP_011266449.1; NC_007005.1.
DR   RefSeq; YP_233615.1; NC_007005.1.
DR   STRING; 205918.Psyr_0507; -.
DR   EnsemblBacteria; AAY35577; AAY35577; Psyr_0507.
DR   GeneID; 3365983; -.
DR   KEGG; psb:Psyr_0507; -.
DR   PATRIC; fig|205918.7.peg.526; -.
DR   eggNOG; ENOG4105CK7; Bacteria.
DR   eggNOG; COG0591; LUCA.
DR   HOGENOM; HOG000282935; -.
DR   KO; K11928; -.
DR   OMA; CWTDLIQ; -.
DR   BioCyc; PSYR205918:G1G4J-508-MONOMER; -.
DR   Proteomes; UP000000426; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005298; F:proline:sodium symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0031402; F:sodium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0015824; P:proline transport; IEA:UniProtKB-UniRule.
DR   CDD; cd11475; SLC5sbd_PutP; 1.
DR   Gene3D; 1.20.1730.10; -; 1.
DR   InterPro; IPR038377; Na/Glc_symporter_sf.
DR   InterPro; IPR011851; Na/Pro_symporter.
DR   InterPro; IPR001734; Na/solute_symporter.
DR   InterPro; IPR018212; Na/solute_symporter_CS.
DR   Pfam; PF00474; SSF; 1.
DR   TIGRFAMs; TIGR02121; Na_Pro_sym; 1.
DR   TIGRFAMs; TIGR00813; sss; 1.
DR   PROSITE; PS00456; NA_SOLUT_SYMP_1; 1.
DR   PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q4ZZ45.
DR   SWISS-2DPAGE; Q4ZZ45.
KW   Amino-acid transport {ECO:0000256|RuleBase:RU366012};
KW   Cell inner membrane {ECO:0000256|RuleBase:RU366012};
KW   Cell membrane {ECO:0000256|SAAS:SAAS00735906};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000426};
KW   Ion transport {ECO:0000256|RuleBase:RU366012};
KW   Membrane {ECO:0000256|RuleBase:RU366012};
KW   Sodium {ECO:0000256|RuleBase:RU366012};
KW   Sodium transport {ECO:0000256|RuleBase:RU366012};
KW   Symport {ECO:0000256|RuleBase:RU366012};
KW   Transmembrane {ECO:0000256|RuleBase:RU366012};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU366012};
KW   Transport {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM     32     50       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    100    118       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    148    176       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    188    209       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    216    236       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    256    273       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    299    320       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    349    374       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    395    415       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    427    446       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    453    471       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    477    497       Helical. {ECO:0000256|RuleBase:RU366012}.
SQ   SEQUENCE   519 AA;  55430 MW;  A204B9022FE3DED4 CRC64;
     MCRISVAIPF GIGCQHKNNA KAELMSVSNP TLITFVIYIA AMVLIGLMAY RSTNNLSDYI
     LGGRSLGSVV TALSAGASDM SGWLLMGLPG AIYMSGLSES WIAIGLIIGA YLNWLFVAGR
     LRVQTEHNGD ALTLPDYFSS RFEDNSGLLR IISAIVILVF FTIYCASGIV AGARLFESTF
     GMSYETALWA GAAATIAYTF VGGFLAVSWT DTVQATLMIF ALILTPVIVL LATGGVDTTF
     LAIEAKDPTS FDMFKNTTFI GIISLLGWGL GYFGQPHILA RFMAADSVKS IASARRISMA
     WMILCLGGTV AVGFFGIAYF SAHPEVAGPV TENPERVFIE LAKLLFNPWI AGVLLSAILA
     AVMSTLSCQL LVCSSALTED FYKAYLRKGA SQVELVWVGR AMVLLIAIIA ILLAANPENR
     VLGLVSYAWA GFGAAFGPVV LISVLWKGMT RNGALAGVIM GAATVVLWKQ FSTMGLYEII
     PGFILASISI VVFSLIGKPA SASMQTRFLA AEQDFKANR
//

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