(data stored in ACNUC7421 zone)

SWISSPROT: DNAA_THEFY

ID   DNAA_THEFY              Reviewed;         615 AA.
AC   Q47U23;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   08-MAY-2019, entry version 95.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=Tfu_0001;
OS   Thermobifida fusca (strain YX).
OC   Bacteria; Actinobacteria; Streptosporangiales; Nocardiopsaceae;
OC   Thermobifida.
OX   NCBI_TaxID=269800;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YX;
RX   PubMed=17209016; DOI=10.1128/JB.01899-06;
RA   Lykidis A., Mavromatis K., Ivanova N., Anderson I., Land M.,
RA   DiBartolo G., Martinez M., Lapidus A., Lucas S., Copeland A.,
RA   Richardson P., Wilson D.B., Kyrpides N.;
RT   "Genome sequence and analysis of the soil cellulolytic actinomycete
RT   Thermobifida fusca YX.";
RL   J. Bacteriol. 189:2477-2486(2007).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; CP000088; AAZ54041.1; -; Genomic_DNA.
DR   RefSeq; WP_011290450.1; NC_007333.1.
DR   SMR; Q47U23; -.
DR   STRING; 269800.Tfu_0001; -.
DR   EnsemblBacteria; AAZ54041; AAZ54041; Tfu_0001.
DR   KEGG; tfu:Tfu_0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; ATHIERN; -.
DR   OrthoDB; 219876at2; -.
DR   BioCyc; TFUS269800:G1G4Q-1-MONOMER; -.
DR   Proteomes; UP000000434; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q47U23.
DR   SWISS-2DPAGE; Q47U23.
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    615       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000048751.
FT   NP_BIND     311    318       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   615 AA;  67695 MW;  387B3711FF4D74F7 CRC64;
     MSEGQINLAM VWSRVLDNLD NNSLPPQHRA WLPQTRPLGL IEDTALLAAP NEFAKEILET
     RLRTVISQAL SAELGREIRV AVTVDPSAVP PSAPTEEASS TSSPDSSHPA PDQGSASYSG
     PRDTARQQAW SQQPVLPDPQ PTAPQFTPSG RPGPLPGEPF SRGPDLLSSG WNPSSADPGS
     PASPAPVAES DTGPRYQSWD TSAPHWDQPN RWETPRPWEG GPHPGAGNRP HDVGGDSGVP
     SAEQPPVTPP LGVTERGDGS TNPTSGGPDQ LNPKYTFDTF VIGSSNRFAH AAAVAVAEAP
     AKAYNPLFVY GGSGLGKTHL LHAIGHYTQR LYEGARVRYV SSEEFTNEFI NSIRDGKADG
     FRRRYRDIDV LLVDDIQFLE NKEQTQEEFF HTFNTLHNSN KQIVISSDRP PKQLVTLEDR
     LRNRFEWGLI TDVQPPELET RIAILRKKAA QEGLNAPPEV LEFIASKIST NIRELEGALI
     RVTAFASLNR QSVDLHLTSI VLRDLIPNDE VPEITAAEIM AQTASYFGLT PEDLCGTSRS
     RVLVTARQIA MYLCRELTDL SLPKIGQQFG RDHTTVMHAD RKIRSLMAER RSIYNQVTEL
     TNRIKQQAHH NHHHL
//

If you have problems or comments...

PBIL Back to PBIL home page