(data stored in ACNUC7421 zone)

SWISSPROT: Q47TR6_THEFY

ID   Q47TR6_THEFY            Unreviewed;       102 AA.
AC   Q47TR6;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   08-MAY-2019, entry version 75.
DE   RecName: Full=Transcriptional regulator WhiB {ECO:0000256|HAMAP-Rule:MF_01479};
GN   Name=whiB {ECO:0000256|HAMAP-Rule:MF_01479};
GN   OrderedLocusNames=Tfu_0110 {ECO:0000313|EMBL:AAZ54148.1};
OS   Thermobifida fusca (strain YX).
OC   Bacteria; Actinobacteria; Streptosporangiales; Nocardiopsaceae;
OC   Thermobifida.
OX   NCBI_TaxID=269800 {ECO:0000313|EMBL:AAZ54148.1, ECO:0000313|Proteomes:UP000000434};
RN   [1] {ECO:0000313|Proteomes:UP000000434}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YX {ECO:0000313|Proteomes:UP000000434};
RX   PubMed=17209016; DOI=10.1128/JB.01899-06;
RA   Lykidis A., Mavromatis K., Ivanova N., Anderson I., Land M.,
RA   DiBartolo G., Martinez M., Lapidus A., Lucas S., Copeland A.,
RA   Richardson P., Wilson D.B., Kyrpides N.;
RT   "Genome sequence and analysis of the soil cellulolytic actinomycete
RT   Thermobifida fusca YX.";
RL   J. Bacteriol. 189:2477-2486(2007).
CC   -!- FUNCTION: Acts as a transcriptional regulator. Probably redox-
CC       responsive. The apo- but not holo-form probably binds DNA.
CC       {ECO:0000256|HAMAP-Rule:MF_01479}.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01479};
CC       Note=Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation
CC       of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
CC       {ECO:0000256|HAMAP-Rule:MF_01479};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01479}.
CC   -!- PTM: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
CC       {ECO:0000256|HAMAP-Rule:MF_01479}.
CC   -!- PTM: Upon Fe-S cluster removal intramolecular disulfide bonds are
CC       formed. {ECO:0000256|HAMAP-Rule:MF_01479}.
CC   -!- SIMILARITY: Belongs to the WhiB family. {ECO:0000256|HAMAP-
CC       Rule:MF_01479}.
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DR   EMBL; CP000088; AAZ54148.1; -; Genomic_DNA.
DR   RefSeq; WP_011290557.1; NC_007333.1.
DR   STRING; 269800.Tfu_0110; -.
DR   EnsemblBacteria; AAZ54148; AAZ54148; Tfu_0110.
DR   KEGG; tfu:Tfu_0110; -.
DR   eggNOG; ENOG4105N0U; Bacteria.
DR   eggNOG; ENOG4111W0R; LUCA.
DR   HOGENOM; HOG000247629; -.
DR   KO; K18955; -.
DR   OMA; FAAQRKH; -.
DR   OrthoDB; 1929976at2; -.
DR   BioCyc; TFUS269800:G1G4Q-112-MONOMER; -.
DR   Proteomes; UP000000434; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0035731; F:dinitrosyl-iron complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01479; WhiB; 1.
DR   InterPro; IPR034768; 4FE4S_WBL.
DR   InterPro; IPR003482; Whib.
DR   PANTHER; PTHR38839; PTHR38839; 1.
DR   Pfam; PF02467; Whib; 1.
DR   PROSITE; PS51674; 4FE4S_WBL; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q47TR6.
DR   SWISS-2DPAGE; Q47TR6.
KW   4Fe-4S {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000434};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Disulfide bond {ECO:0000256|HAMAP-Rule:MF_01479};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Iron {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Iron-sulfur {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000434};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   DOMAIN       11     67       4Fe-4S Wbl-type. {ECO:0000259|PROSITE:
FT                                PS51674}.
FT   METAL        12     12       Dinitrosyliron [4Fe-8(NO)]; alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        12     12       Iron-sulfur (4Fe-4S); alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        34     34       Dinitrosyliron [4Fe-8(NO)]; alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        34     34       Iron-sulfur (4Fe-4S); alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        37     37       Dinitrosyliron [4Fe-8(NO)]; alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        37     37       Iron-sulfur (4Fe-4S); alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        43     43       Dinitrosyliron [4Fe-8(NO)]; alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        43     43       Iron-sulfur (4Fe-4S); alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
SQ   SEQUENCE   102 AA;  11636 MW;  495C4F0E628D656E CRC64;
     MWSTDWAARA ACREIDPDSL FVQGAAQNRA KLICRGCPVR TECLADALDN RIEFGVWGGM
     TERERRALLR RRPEVTSWRA LLEDARQHYQ QSGAAKDQFV KG
//

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