(data stored in ACNUC7421 zone)

SWISSPROT: Q47TC6_THEFY

ID   Q47TC6_THEFY            Unreviewed;       380 AA.
AC   Q47TC6;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   08-MAY-2019, entry version 87.
DE   SubName: Full=Thiolase {ECO:0000313|EMBL:AAZ54291.1};
DE            EC=2.3.1.16 {ECO:0000313|EMBL:AAZ54291.1};
GN   OrderedLocusNames=Tfu_0253 {ECO:0000313|EMBL:AAZ54291.1};
OS   Thermobifida fusca (strain YX).
OC   Bacteria; Actinobacteria; Streptosporangiales; Nocardiopsaceae;
OC   Thermobifida.
OX   NCBI_TaxID=269800 {ECO:0000313|EMBL:AAZ54291.1, ECO:0000313|Proteomes:UP000000434};
RN   [1] {ECO:0000313|Proteomes:UP000000434}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YX {ECO:0000313|Proteomes:UP000000434};
RX   PubMed=17209016; DOI=10.1128/JB.01899-06;
RA   Lykidis A., Mavromatis K., Ivanova N., Anderson I., Land M.,
RA   DiBartolo G., Martinez M., Lapidus A., Lucas S., Copeland A.,
RA   Richardson P., Wilson D.B., Kyrpides N.;
RT   "Genome sequence and analysis of the soil cellulolytic actinomycete
RT   Thermobifida fusca YX.";
RL   J. Bacteriol. 189:2477-2486(2007).
CC   -!- SIMILARITY: Belongs to the thiolase family.
CC       {ECO:0000256|RuleBase:RU003557}.
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DR   EMBL; CP000088; AAZ54291.1; -; Genomic_DNA.
DR   RefSeq; WP_011290700.1; NC_007333.1.
DR   STRING; 269800.Tfu_0253; -.
DR   EnsemblBacteria; AAZ54291; AAZ54291; Tfu_0253.
DR   KEGG; tfu:Tfu_0253; -.
DR   eggNOG; ENOG4105CHU; Bacteria.
DR   eggNOG; COG0183; LUCA.
DR   HOGENOM; HOG000012239; -.
DR   KO; K00626; -.
DR   OMA; LMCEKWG; -.
DR   OrthoDB; 550338at2; -.
DR   BioCyc; TFUS269800:G1G4Q-257-MONOMER; -.
DR   Proteomes; UP000000434; Chromosome.
DR   GO; GO:0003988; F:acetyl-CoA C-acyltransferase activity; IEA:UniProtKB-EC.
DR   CDD; cd00751; thiolase; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR002155; Thiolase.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR020617; Thiolase_C.
DR   InterPro; IPR020613; Thiolase_CS.
DR   InterPro; IPR020616; Thiolase_N.
DR   Pfam; PF02803; Thiolase_C; 1.
DR   Pfam; PF00108; Thiolase_N; 1.
DR   PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   TIGRFAMs; TIGR01930; AcCoA-C-Actrans; 1.
DR   PROSITE; PS00737; THIOLASE_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q47TC6.
DR   SWISS-2DPAGE; Q47TC6.
KW   Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW   ECO:0000313|EMBL:AAZ54291.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000434};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000434};
KW   Transferase {ECO:0000256|RuleBase:RU003557,
KW   ECO:0000313|EMBL:AAZ54291.1}.
FT   DOMAIN        5    249       Thiolase_N. {ECO:0000259|Pfam:PF00108}.
FT   DOMAIN      257    379       Thiolase_C. {ECO:0000259|Pfam:PF02803}.
FT   ACT_SITE     89     89       Acyl-thioester intermediate.
FT                                {ECO:0000256|PIRSR:PIRSR000429-1}.
FT   ACT_SITE    336    336       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000429-1}.
FT   ACT_SITE    366    366       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000429-1}.
SQ   SEQUENCE   380 AA;  39832 MW;  7615375357E19B2B CRC64;
     MAEAYIVGAV RTPIGTRKGA LAAVHPADLG AHVLKELVNR TGIDPAAVED VIMGCVTQVG
     PQALDLARTA WLSAGLPEST PGVTIDRQCG SSQQAVHFAA QGVMSGTQDL VIAAGVENMG
     MVPMGANVQF AVDNGLSVYG QGWVERYGTQ EISQFRGAQL MCEKWGYTRE DLEKYALESH
     RRAAAAIEAG YFDAETAPLA GVTHDEGVRP DTSLEKMAEL APLREGWALT AAVSSQISVG
     ASALLIASER AVAEHGLTPL ARIVQLALAG DDPVYMLTAP IPATRIALRK AGLDIDDIDV
     VEINEAFAPV PMAWIDEIGA DPAKVNPNGG AIALGHPLGA TGAVLMTKLV HELRRTGGRY
     GLQTMCEGGG QANVTIIERV
//

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