(data stored in ACNUC7421 zone)

SWISSPROT: Q47SU3_THEFY

ID   Q47SU3_THEFY            Unreviewed;       407 AA.
AC   Q47SU3;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   08-MAY-2019, entry version 90.
DE   SubName: Full=Thiolase {ECO:0000313|EMBL:AAZ54474.1};
DE            EC=2.3.1.16 {ECO:0000313|EMBL:AAZ54474.1};
GN   OrderedLocusNames=Tfu_0436 {ECO:0000313|EMBL:AAZ54474.1};
OS   Thermobifida fusca (strain YX).
OC   Bacteria; Actinobacteria; Streptosporangiales; Nocardiopsaceae;
OC   Thermobifida.
OX   NCBI_TaxID=269800 {ECO:0000313|EMBL:AAZ54474.1, ECO:0000313|Proteomes:UP000000434};
RN   [1] {ECO:0000313|Proteomes:UP000000434}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YX {ECO:0000313|Proteomes:UP000000434};
RX   PubMed=17209016; DOI=10.1128/JB.01899-06;
RA   Lykidis A., Mavromatis K., Ivanova N., Anderson I., Land M.,
RA   DiBartolo G., Martinez M., Lapidus A., Lucas S., Copeland A.,
RA   Richardson P., Wilson D.B., Kyrpides N.;
RT   "Genome sequence and analysis of the soil cellulolytic actinomycete
RT   Thermobifida fusca YX.";
RL   J. Bacteriol. 189:2477-2486(2007).
CC   -!- SIMILARITY: Belongs to the thiolase family.
CC       {ECO:0000256|RuleBase:RU003557}.
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DR   EMBL; CP000088; AAZ54474.1; -; Genomic_DNA.
DR   RefSeq; WP_011290883.1; NC_007333.1.
DR   STRING; 269800.Tfu_0436; -.
DR   EnsemblBacteria; AAZ54474; AAZ54474; Tfu_0436.
DR   KEGG; tfu:Tfu_0436; -.
DR   eggNOG; ENOG4105CHU; Bacteria.
DR   eggNOG; COG0183; LUCA.
DR   HOGENOM; HOG000012239; -.
DR   KO; K00626; -.
DR   OMA; LMAGQGQ; -.
DR   OrthoDB; 330994at2; -.
DR   BioCyc; TFUS269800:G1G4Q-443-MONOMER; -.
DR   Proteomes; UP000000434; Chromosome.
DR   GO; GO:0003988; F:acetyl-CoA C-acyltransferase activity; IEA:UniProtKB-EC.
DR   CDD; cd00751; thiolase; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR002155; Thiolase.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR020617; Thiolase_C.
DR   InterPro; IPR020613; Thiolase_CS.
DR   InterPro; IPR020616; Thiolase_N.
DR   Pfam; PF02803; Thiolase_C; 1.
DR   Pfam; PF00108; Thiolase_N; 1.
DR   PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   TIGRFAMs; TIGR01930; AcCoA-C-Actrans; 1.
DR   PROSITE; PS00737; THIOLASE_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q47SU3.
DR   SWISS-2DPAGE; Q47SU3.
KW   Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW   ECO:0000313|EMBL:AAZ54474.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000434};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000434};
KW   Transferase {ECO:0000256|RuleBase:RU003557,
KW   ECO:0000313|EMBL:AAZ54474.1}.
FT   DOMAIN        5    274       Thiolase_N. {ECO:0000259|Pfam:PF00108}.
FT   DOMAIN      283    405       Thiolase_C. {ECO:0000259|Pfam:PF02803}.
FT   ACT_SITE     90     90       Acyl-thioester intermediate.
FT                                {ECO:0000256|PIRSR:PIRSR000429-1}.
FT   ACT_SITE    362    362       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000429-1}.
FT   ACT_SITE    392    392       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000429-1}.
SQ   SEQUENCE   407 AA;  43004 MW;  3C973C5572074A80 CRC64;
     MPEAVIVATA RSPIGRAFKG SLKDIRPDDL TAQIISAALA KVPQLDPATI DDLLLGCGLP
     GGEQGFNMAR VVAVQLGLDS VPGTTITRYC SSSLQTTRMA FHAIKAGEGD VFISAGVEMV
     SRFTKGNSDT LPDTKNPLFA EAEARTARRA EGGAEPWRDP REEGKLPDIY IAMGQTAENV
     AQLRGVSRQR QDEFAVRSQN LAEKALDNGF WEREITPVTL PDGTVVSTDD GPRRGTTYEK
     VAALDPVFRP DGTVTAGNCC PLNDGAAALI IMSDRKAAEL GITPLARIVS TGVSALSPEI
     MGLGPVEASR QALARANMSI RDIDLVEINE AFAAQVLPSA DDLGIDIDSQ LNVNGGAIAI
     GHPFGMTGAR ITTTLINALQ FHDKTFGLET MCVGGGQGMA AIFERLS
//

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