(data stored in ACNUC7421 zone)

SWISSPROT: Q47SK6_THEFY

ID   Q47SK6_THEFY            Unreviewed;      1044 AA.
AC   Q47SK6;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   08-MAY-2019, entry version 101.
DE   SubName: Full=Putative ATP-dependent DNA helicase {ECO:0000313|EMBL:AAZ54561.1};
GN   OrderedLocusNames=Tfu_0523 {ECO:0000313|EMBL:AAZ54561.1};
OS   Thermobifida fusca (strain YX).
OC   Bacteria; Actinobacteria; Streptosporangiales; Nocardiopsaceae;
OC   Thermobifida.
OX   NCBI_TaxID=269800 {ECO:0000313|EMBL:AAZ54561.1, ECO:0000313|Proteomes:UP000000434};
RN   [1] {ECO:0000313|Proteomes:UP000000434}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YX {ECO:0000313|Proteomes:UP000000434};
RX   PubMed=17209016; DOI=10.1128/JB.01899-06;
RA   Lykidis A., Mavromatis K., Ivanova N., Anderson I., Land M.,
RA   DiBartolo G., Martinez M., Lapidus A., Lucas S., Copeland A.,
RA   Richardson P., Wilson D.B., Kyrpides N.;
RT   "Genome sequence and analysis of the soil cellulolytic actinomycete
RT   Thermobifida fusca YX.";
RL   J. Bacteriol. 189:2477-2486(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|SAAS:SAAS01129065};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|SAAS:SAAS01099290};
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000256|SAAS:SAAS00709641}.
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DR   EMBL; CP000088; AAZ54561.1; -; Genomic_DNA.
DR   RefSeq; WP_011290970.1; NC_007333.1.
DR   STRING; 269800.Tfu_0523; -.
DR   EnsemblBacteria; AAZ54561; AAZ54561; Tfu_0523.
DR   KEGG; tfu:Tfu_0523; -.
DR   eggNOG; ENOG4105F1I; Bacteria.
DR   eggNOG; COG0210; LUCA.
DR   eggNOG; COG2887; LUCA.
DR   HOGENOM; HOG000247970; -.
DR   OMA; GVQEGLW; -.
DR   OrthoDB; 137860at2; -.
DR   BioCyc; TFUS269800:G1G4Q-532-MONOMER; -.
DR   Proteomes; UP000000434; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004003; F:ATP-dependent DNA helicase activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.160; -; 1.
DR   Gene3D; 3.90.320.10; -; 1.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR011604; Exonuc_phg/RecB_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   InterPro; IPR034739; UvrD/AddA_N.
DR   PANTHER; PTHR11070; PTHR11070; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q47SK6.
DR   SWISS-2DPAGE; Q47SK6.
KW   ATP-binding {ECO:0000256|SAAS:SAAS00146071};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000434};
KW   DNA damage {ECO:0000256|SAAS:SAAS01099294};
KW   DNA repair {ECO:0000256|SAAS:SAAS01099287};
KW   DNA-binding {ECO:0000256|SAAS:SAAS00745286};
KW   Exonuclease {ECO:0000256|SAAS:SAAS01033115};
KW   Helicase {ECO:0000256|SAAS:SAAS00553650, ECO:0000313|EMBL:AAZ54561.1};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00146062};
KW   Nuclease {ECO:0000256|SAAS:SAAS01033141};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00145996};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000434}.
FT   DOMAIN       19    319       UvrD-like helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51198}.
FT   DOMAIN      330    630       UvrD-like helicase C-terminal.
FT                                {ECO:0000259|PROSITE:PS51217}.
FT   COILED       75     95       {ECO:0000256|SAM:Coils}.
FT   COILED      873    893       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1044 AA;  115344 MW;  444F726655840EDB CRC64;
     MDNPPYRLVR RIRHRAPAPE LDDDQRRVVD HEGGPLLVLA GPGTGKTTTI VEAIVDRVEN
     RGVDPAHVLV LTFSRKAAQE LRERITARLR RTVREPLALT FHSYAYALIR REFQRVGDHA
     PRLLSGPEQL MEVRELLKGE LADGAPGWPE QLRPMLHTRG FAEELRDFLM RVQERGLHAD
     DVRELGRRHG REDWVAAGGF LERYTGRFDI APVPTFNYAE LVRVAANLLN DPDIQARERA
     ARKVVFVDEY QDTDPAQEEL LHALAGDGRD LVVVGDPDQS IYGFRGAEVR NILNFPDRFR
     TPTGDPAPVV ALHTCRRSGA ELLRVSRALA QRLPAVPGPG GEGVNAHRNL VPAEGTPPGR
     ARMLLAESPV HEAAVIADLL RRAHLIDGVP WSRMAVLVRS VTRHVPVLRR ALIAADVPVT
     VDGDDLPLAS EPLVRSMLLL LRCAFHPERL DEEAAHNLLT SAFGEADALG LRRLGRALRQ
     LELDAGGRRP AAALLAEILH DPRDLVMVDP EVRAPAERIA TLLRLVRDSI AEGANAEEVL
     WRMWHHSGLA DTLLRASQAG GRHGAAADRE LDSVMALFER AARYCDRLPP GSPEGFLEDL
     EAQEIPGDTL AEQAPQGETV RILTAHRSKG LEWDLVVVAG VQEGTWPDLR LRGSLLGVEQ
     LLDTVGGFAE TSPAAVVSKQ LDEERRLFYV ALTRARRELV VTAVGGEDVE ERPSRFLTEL
     GLGEPERLAT GYRWLSLPAL VADLRATLLD PHTDEPVRRA AAAHLARLAD AGVRGADPAE
     WYALTELSDS SPLVLEGEQI RISPSQVEKF TTCELRWLLE TAAGAEKRRA ASGIGSIVHA
     LARIAAENPD LPELLRRMDQ IWSDLDFGGP WYAEKQRERA EEMLQRFLDW QKENPRELVA
     TEKKFRVEVG NIEISGQVDR LERDAEGRGV IVDIKTGTAV PDREISRHPQ LGVYQLALLM
     AAFEHYGLVE PGGAALLQIG DRKTAKEQTQ PALADDADPE WPQRLVQKVA AGMAGARFRA
     KATPSCRHCS VRASCPVQSE GDHV
//

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