(data stored in ACNUC7421 zone)

SWISSPROT: Q47SK5_THEFY

ID   Q47SK5_THEFY            Unreviewed;      1108 AA.
AC   Q47SK5;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   08-MAY-2019, entry version 109.
DE   SubName: Full=Putative DNA helicase {ECO:0000313|EMBL:AAZ54562.1};
GN   OrderedLocusNames=Tfu_0524 {ECO:0000313|EMBL:AAZ54562.1};
OS   Thermobifida fusca (strain YX).
OC   Bacteria; Actinobacteria; Streptosporangiales; Nocardiopsaceae;
OC   Thermobifida.
OX   NCBI_TaxID=269800 {ECO:0000313|EMBL:AAZ54562.1, ECO:0000313|Proteomes:UP000000434};
RN   [1] {ECO:0000313|Proteomes:UP000000434}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YX {ECO:0000313|Proteomes:UP000000434};
RX   PubMed=17209016; DOI=10.1128/JB.01899-06;
RA   Lykidis A., Mavromatis K., Ivanova N., Anderson I., Land M.,
RA   DiBartolo G., Martinez M., Lapidus A., Lucas S., Copeland A.,
RA   Richardson P., Wilson D.B., Kyrpides N.;
RT   "Genome sequence and analysis of the soil cellulolytic actinomycete
RT   Thermobifida fusca YX.";
RL   J. Bacteriol. 189:2477-2486(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|SAAS:SAAS01129065};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|SAAS:SAAS01099290};
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000256|SAAS:SAAS00709641}.
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DR   EMBL; CP000088; AAZ54562.1; -; Genomic_DNA.
DR   RefSeq; WP_011290971.1; NC_007333.1.
DR   STRING; 269800.Tfu_0524; -.
DR   EnsemblBacteria; AAZ54562; AAZ54562; Tfu_0524.
DR   KEGG; tfu:Tfu_0524; -.
DR   eggNOG; ENOG4106AQX; Bacteria.
DR   eggNOG; COG0210; LUCA.
DR   eggNOG; COG2887; LUCA.
DR   HOGENOM; HOG000247959; -.
DR   KO; K03657; -.
DR   OMA; SGHWWGP; -.
DR   OrthoDB; 137860at2; -.
DR   BioCyc; TFUS269800:G1G4Q-533-MONOMER; -.
DR   Proteomes; UP000000434; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004003; F:ATP-dependent DNA helicase activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   InterPro; IPR034739; UvrD/AddA_N.
DR   PANTHER; PTHR11070; PTHR11070; 2.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF52980; SSF52980; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q47SK5.
DR   SWISS-2DPAGE; Q47SK5.
KW   ATP-binding {ECO:0000256|SAAS:SAAS00146071};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000434};
KW   DNA damage {ECO:0000256|SAAS:SAAS01099294};
KW   DNA repair {ECO:0000256|SAAS:SAAS01099287};
KW   DNA-binding {ECO:0000256|SAAS:SAAS00745286};
KW   Exonuclease {ECO:0000256|SAAS:SAAS01033115};
KW   Helicase {ECO:0000256|SAAS:SAAS00553650, ECO:0000313|EMBL:AAZ54562.1};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00146062};
KW   Nuclease {ECO:0000256|SAAS:SAAS01033141};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00145996};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000434}.
FT   DOMAIN       17    340       UvrD-like helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51198}.
FT   DOMAIN      341    677       UvrD-like helicase C-terminal.
FT                                {ECO:0000259|PROSITE:PS51217}.
FT   COILED       73     93       {ECO:0000256|SAM:Coils}.
FT   COILED      505    529       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1108 AA;  122397 MW;  3BFA923C20D956D7 CRC64;
     MTDVYGPAQL ARLLGLPEPT PEQAAVIAAP LRPGLVVAGA GSGKSETMAA RVVWLVANGH
     VRPEQVLGLT FTRKAAAELA ERVRKRLDQL RGAGVVPDDV LDGEPTVATY NAYATRLVGD
     HALREAIEPT TRIITPAIAW QFVHRVVSTY DGPMDAVTSA PATVVHDVLA LAQELAEHLC
     TPDDVRAYGD WLRERAAQLK KTPALVRDLL AVQRHREQLL PLLEQFAQLK AEREVMDYSD
     QVALAARIAQ RHPEVGRIER ERYAVVLLDE YQDTSHAQLV LLQSLFGNGH PVTAVGDPCQ
     SIYGWRGASA GNLSRFPVDF PEKPDRPAPV RQLSTSFRNG ERILEVAKRI AEPLRAAARD
     VPVLYPGPAR AGRGRVTCAL LRTETEEAEW IAEQIDRALR ESAEHHTAPD GLPWPEQEHR
     GPLSYGDIAV LCRKRAQFPV IRRALEERGI PVEVVGLGGL IEVPEVRDIV ATLRVLHDPT
     AANELARILT GPRWRLGPRD LVALNQRAKE LAEEARRDLR GEAAEARVDE EDPLRQTVLD
     LTAEAGSLLD ALDDLGPPER YSATGYQRLQ ALSEELRTLR TRISQPLPDL IMEVERVLGL
     DIEVGARPGR DQSAARADLD AFVDAAVRFS GSTDTPTLSA FLAYLTSAED TEHGLEPGER
     VGSSNTVKLM TVHAAKGLQW PMVVIPGLSR GQFPGVPKTV KGWTGKAASL PFALRGDRDS
     LPELADVTVQ EIKQFTAAER ARELMEQRRL AYVAVTRAAF SLVCTGHWWG QETQRSRGPS
     EFLEEIREVC ETGVGQVALW TDPPDEGEPN PQLVADNSVV WPPQTDERRD AAERAAALVA
     RYRNGEWERE LALMNRALLR PAANRRIRDW ARDVELLLRH RDQEEGAPRV IEVELPDHLT
     VSALVSLARD PAALAQQIRR PLPRPPAPHA RRGTAFHTWL ERRFGQETLI DPHELPGAAD
     ETATGDADLD ELQRQFEQSV WADRVPLEVE VPFETIIGDR LVRGRMDAVF HDPEDDVYEV
     VDWKTGRLPA TERERRAAAV QLAAYRVAWA RIADIPLERV RAAFHYVRAN VTVYPEDLLD
     ADGLAALIAA VPQPSVPGEA AEGATGDR
//

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