(data stored in ACNUC7421 zone)

SWISSPROT: Q47SG3_THEFY

ID   Q47SG3_THEFY            Unreviewed;      1214 AA.
AC   Q47SG3;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   08-MAY-2019, entry version 94.
DE   SubName: Full=2-oxoglutarate dehydrogenase E1 component {ECO:0000313|EMBL:AAZ54604.1};
DE            EC=1.2.4.2 {ECO:0000313|EMBL:AAZ54604.1};
GN   OrderedLocusNames=Tfu_0566 {ECO:0000313|EMBL:AAZ54604.1};
OS   Thermobifida fusca (strain YX).
OC   Bacteria; Actinobacteria; Streptosporangiales; Nocardiopsaceae;
OC   Thermobifida.
OX   NCBI_TaxID=269800 {ECO:0000313|EMBL:AAZ54604.1, ECO:0000313|Proteomes:UP000000434};
RN   [1] {ECO:0000313|Proteomes:UP000000434}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YX {ECO:0000313|Proteomes:UP000000434};
RX   PubMed=17209016; DOI=10.1128/JB.01899-06;
RA   Lykidis A., Mavromatis K., Ivanova N., Anderson I., Land M.,
RA   DiBartolo G., Martinez M., Lapidus A., Lucas S., Copeland A.,
RA   Richardson P., Wilson D.B., Kyrpides N.;
RT   "Genome sequence and analysis of the soil cellulolytic actinomycete
RT   Thermobifida fusca YX.";
RL   J. Bacteriol. 189:2477-2486(2007).
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DR   EMBL; CP000088; AAZ54604.1; -; Genomic_DNA.
DR   RefSeq; WP_011291013.1; NC_007333.1.
DR   STRING; 269800.Tfu_0566; -.
DR   EnsemblBacteria; AAZ54604; AAZ54604; Tfu_0566.
DR   KEGG; tfu:Tfu_0566; -.
DR   eggNOG; ENOG4105C7P; Bacteria.
DR   eggNOG; COG0508; LUCA.
DR   eggNOG; COG0567; LUCA.
DR   HOGENOM; HOG000259587; -.
DR   KO; K00164; -.
DR   OMA; IDMVCYR; -.
DR   OrthoDB; 29166at2; -.
DR   BioCyc; TFUS269800:G1G4Q-576-MONOMER; -.
DR   Proteomes; UP000000434; Chromosome.
DR   GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:UniProtKB-EC.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0016746; F:transferase activity, transferring acyl groups; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   Gene3D; 3.30.559.10; -; 1.
DR   InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR   InterPro; IPR032106; 2-oxogl_dehyd_N.
DR   InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR031717; KGD_C.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   PANTHER; PTHR23152; PTHR23152; 1.
DR   Pfam; PF00198; 2-oxoacid_dh; 1.
DR   Pfam; PF16078; 2-oxogl_dehyd_N; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF16870; OxoGdeHyase_C; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   TIGRFAMs; TIGR00239; 2oxo_dh_E1; 1.
PE   4: Predicted;
DR   PRODOM; Q47SG3.
DR   SWISS-2DPAGE; Q47SG3.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000434};
KW   Oxidoreductase {ECO:0000313|EMBL:AAZ54604.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000434}.
FT   DOMAIN      873   1066       Transket_pyr. {ECO:0000259|SMART:
FT                                SM00861}.
FT   COILED      771    805       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1214 AA;  134408 MW;  DB52AC41D6A70A6B CRC64;
     MSSEASQPLT DFGPNEWLVD ELHRKYLADP NSVDKAWWNF FADYKSGTAA DGSTSPAKST
     VAGNGAGGAV RAAASKAAAR PATATTPDGS DDALAVSQER LRGASARTAA NMESSLTLPT
     ATSVRAVPVK LLFDNRIVIN NHLRRARGGK VSFTHLIGYA MVKALESVPV MNYSYTEIDG
     KPAVAKPKHV NFGLAIDLAK PDGSRQLVVP NIKAADTMNF KEFWSACEEL VRKARSNKLT
     VADFQGTTIT LTNPGGIGTV HSVPRLMPGQ GTILGVGAME YPAEFQGASP ATLNELAVSK
     VMTLTSTYDH RIIQGAESGE FLRRIHQLLL GEDGFYDEIF ESLRIPYEPV RWVQDISVNR
     DNQLDKATRV QELIHAYRVR GHLMADTDPL EYKQRRHPDL DVLEHGLTLW DLDREFPTGG
     FGGKPVMKLR EILGILRDSY CRTVGIEYMH IQSPEEREWI QARVEREPEK LSREEQLHIL
     KLLNSAEAFE TFLQTKYVGQ KRFSLEGGES LIPLLDGVIT KAARAQLDEV VIGMAHRGRL
     NVLANICGKS YAQIFGEFEG NLDPRSAHGS GDVKYHLGTE GTFTTITGEK IAISLAANPS
     HLETVNPVAE GIVRAKQDIL NKGATGFTVL PILIHGDAAF AGQGVVAETL NLSQLRGYRT
     GGTIHIIVNN QVGFTTSPKD SRSSVYATDV ARMVQAPIFH VNGDDPEAVV RVARLAFAYR
     QEFNKDVVID LVCYRRRGHN EADNPSFTQP LMYDIIDAKR STRKLYTEAL IGRGDITLEE
     AEEALRDYQE QLERAFAETR EAAKKPIEPG SVIKPEVFTE APIDHSATPT AVSEEVIKRV
     AETQVTFPEG FTVHPRLLPQ LQRRVRMVEE NAIDWAMAET LAFGSLLIDG HPVRLVGQDS
     RRGTFGQRHA VLVDRKTGEE YTPLKVFDRG TAKFHVHDSL LSEYAALGFE YGYSLERPDA
     LVAWEAQFGD FVNGAQTVID EYISSGEQKW GQKSSVTLLL PHGYEGQGPD HSSARIERFL
     QLCAQENMTV TIPTTPANYF HLLRWQVKSP YRRPLIVFTP KSMLRHKAAV SAVSEFTSGS
     FRPLIPDTSG IAPEDVRRVI LCAGKIYYEL DAARKRTGDQ HTAIIRVERL YPLPIDEIRQ
     QLRSFPNAGE VLWVQEEPAN MGPWPFVALV FAEQLDRPFT RISRSASSSP ATGSAKRHEV
     EQQALVNTVF PPTE
//

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