(data stored in ACNUC7421 zone)

SWISSPROT: YACG_SHISS

ID   YACG_SHISS              Reviewed;          65 AA.
AC   Q3Z5Q8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   08-MAY-2019, entry version 78.
DE   RecName: Full=DNA gyrase inhibitor YacG {ECO:0000255|HAMAP-Rule:MF_00649};
GN   Name=yacG {ECO:0000255|HAMAP-Rule:MF_00649};
GN   OrderedLocusNames=SSON_0109;
OS   Shigella sonnei (strain Ss046).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=300269;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ss046;
RX   PubMed=16275786; DOI=10.1093/nar/gki954;
RA   Yang F., Yang J., Zhang X., Chen L., Jiang Y., Yan Y., Tang X.,
RA   Wang J., Xiong Z., Dong J., Xue Y., Zhu Y., Xu X., Sun L., Chen S.,
RA   Nie H., Peng J., Xu J., Wang Y., Yuan Z., Wen Y., Yao Z., Shen Y.,
RA   Qiang B., Hou Y., Yu J., Jin Q.;
RT   "Genome dynamics and diversity of Shigella species, the etiologic
RT   agents of bacillary dysentery.";
RL   Nucleic Acids Res. 33:6445-6458(2005).
CC   -!- FUNCTION: Inhibits all the catalytic activities of DNA gyrase by
CC       preventing its interaction with DNA. Acts by binding directly to
CC       the C-terminal domain of GyrB, which probably disrupts DNA binding
CC       by the gyrase. {ECO:0000255|HAMAP-Rule:MF_00649}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00649};
CC       Note=Binds 1 zinc ion. {ECO:0000255|HAMAP-Rule:MF_00649};
CC   -!- SUBUNIT: Interacts with GyrB. {ECO:0000255|HAMAP-Rule:MF_00649}.
CC   -!- SIMILARITY: Belongs to the DNA gyrase inhibitor YacG family.
CC       {ECO:0000255|HAMAP-Rule:MF_00649}.
DR   EMBL; CP000038; AAZ86904.1; -; Genomic_DNA.
DR   SMR; Q3Z5Q8; -.
DR   EnsemblBacteria; AAZ86904; AAZ86904; SSON_0109.
DR   KEGG; ssn:SSON_0109; -.
DR   HOGENOM; HOG000255917; -.
DR   KO; K09862; -.
DR   OMA; FRPFCSD; -.
DR   BioCyc; SSON300269:G1GL2-123-MONOMER; -.
DR   Proteomes; UP000002529; Chromosome.
DR   GO; GO:0008657; F:DNA topoisomerase (ATP-hydrolyzing) inhibitor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 3.30.50.10; -; 1.
DR   HAMAP; MF_00649; DNA_gyrase_inhibitor_YacG; 1.
DR   InterPro; IPR005584; DNA_gyrase_inhibitor_YacG.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR36150; PTHR36150; 1.
DR   Pfam; PF03884; YacG; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q3Z5Q8.
DR   SWISS-2DPAGE; Q3Z5Q8.
KW   Complete proteome; Metal-binding; Zinc.
FT   CHAIN         1     65       DNA gyrase inhibitor YacG.
FT                                /FTId=PRO_1000057000.
FT   METAL         9      9       Zinc. {ECO:0000255|HAMAP-Rule:MF_00649}.
FT   METAL        12     12       Zinc. {ECO:0000255|HAMAP-Rule:MF_00649}.
FT   METAL        28     28       Zinc. {ECO:0000255|HAMAP-Rule:MF_00649}.
FT   METAL        32     32       Zinc. {ECO:0000255|HAMAP-Rule:MF_00649}.
SQ   SEQUENCE   65 AA;  7306 MW;  F2747B62AFE6479D CRC64;
     MSETITVNCP TCGKTVVWGE ISPFRPFCSK RCQLIDLGEW AAEEKRIPSS GDLSESDDWS
     EEPKQ
//

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