(data stored in ACNUC7421 zone)

SWISSPROT: Q3Z5J6_SHISS

ID   Q3Z5J6_SHISS            Unreviewed;       474 AA.
AC   Q3Z5J6;
DT   27-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2005, sequence version 1.
DT   08-MAY-2019, entry version 93.
DE   RecName: Full=Periplasmic serine endoprotease DegP-like {ECO:0000256|RuleBase:RU364067};
DE            EC=3.4.21.107 {ECO:0000256|RuleBase:RU364067};
GN   Name=htrA {ECO:0000313|EMBL:AAZ86966.1};
GN   OrderedLocusNames=SSON_0174 {ECO:0000313|EMBL:AAZ86966.1};
OS   Shigella sonnei (strain Ss046).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=300269 {ECO:0000313|EMBL:AAZ86966.1, ECO:0000313|Proteomes:UP000002529};
RN   [1] {ECO:0000313|EMBL:AAZ86966.1, ECO:0000313|Proteomes:UP000002529}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ss046 {ECO:0000313|EMBL:AAZ86966.1,
RC   ECO:0000313|Proteomes:UP000002529};
RX   PubMed=16275786; DOI=10.1093/nar/gki954;
RA   Yang F., Yang J., Zhang X., Chen L., Jiang Y., Yan Y., Tang X.,
RA   Wang J., Xiong Z., Dong J., Xue Y., Zhu Y., Xu X., Sun L., Chen S.,
RA   Nie H., Peng J., Xu J., Wang Y., Yuan Z., Wen Y., Yao Z., Shen Y.,
RA   Qiang B., Hou Y., Yu J., Jin Q.;
RT   "Genome dynamics and diversity of Shigella species, the etiologic
RT   agents of bacillary dysentery.";
RL   Nucleic Acids Res. 33:6445-6458(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Acts on substrates that are at least partially unfolded.
CC         The cleavage site P1 residue is normally between a pair of
CC         hydrophobic residues, such as Val-|-Val.; EC=3.4.21.107;
CC         Evidence={ECO:0000256|RuleBase:RU364067};
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000256|RuleBase:RU364067}.
CC   -!- SIMILARITY: Belongs to the peptidase S1C family.
CC       {ECO:0000256|RuleBase:RU364067}.
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DR   EMBL; CP000038; AAZ86966.1; -; Genomic_DNA.
DR   SMR; Q3Z5J6; -.
DR   MEROPS; S01.273; -.
DR   EnsemblBacteria; AAZ86966; AAZ86966; SSON_0174.
DR   KEGG; ssn:SSON_0174; -.
DR   HOGENOM; HOG000223642; -.
DR   KO; K04771; -.
DR   OMA; ASFITFK; -.
DR   BioCyc; SSON300269:G1GL2-204-MONOMER; -.
DR   Proteomes; UP000002529; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR011782; Pept_S1C_Do.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   Pfam; PF00595; PDZ; 2.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SMART; SM00228; PDZ; 2.
DR   SUPFAM; SSF50156; SSF50156; 2.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   TIGRFAMs; TIGR02037; degP_htrA_DO; 1.
DR   PROSITE; PS50106; PDZ; 2.
PE   3: Inferred from homology;
DR   PRODOM; Q3Z5J6.
DR   SWISS-2DPAGE; Q3Z5J6.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002529};
KW   Hydrolase {ECO:0000256|RuleBase:RU364067};
KW   Protease {ECO:0000256|RuleBase:RU364067, ECO:0000313|EMBL:AAZ86966.1};
KW   Serine protease {ECO:0000256|RuleBase:RU364067};
KW   Signal {ECO:0000256|RuleBase:RU364067};
KW   Stress response {ECO:0000256|RuleBase:RU364067}.
FT   SIGNAL        1     26       {ECO:0000256|RuleBase:RU364067}.
FT   CHAIN        27    474       Periplasmic serine endoprotease DegP-
FT                                like. {ECO:0000256|RuleBase:RU364067}.
FT                                /FTId=PRO_5010601885.
FT   DOMAIN      280    371       PDZ. {ECO:0000259|PROSITE:PS50106}.
FT   DOMAIN      377    466       PDZ. {ECO:0000259|PROSITE:PS50106}.
SQ   SEQUENCE   474 AA;  49354 MW;  5482E596F74B6D5F CRC64;
     MKKTTLALSA LALSLGLALS PLSATAAETS SATTAQQMPS LAPMLEKVMP SVVSINVEGS
     TTVNTPRMPR NFQQFFGDDS PFCQEGSPFQ SSPFCQGGQG GNGGGQQQKF MALGSGVIID
     ADKGYVVTNN HVVDNATVIK VQLSDGRKFD AKMVGKDPRS DIALIQIQNP KNLTAIKMAD
     SDALRVGDYT VAIGNPFGLG ETVTSGIVSA LGRSGLNAEN YENFIQTDAA INRGNSGGAL
     VNLNGELIGI NTAILAPDGG NIGIGFAIPS NMVKNLTSQM VEYGQVKRGE LGIMGTELNS
     ELAKAMKVDA QRGAFVSQVL PNSSAAKAGI KAGDVITSLN GKPISSFAAL RAQVGTMPVG
     SKLTLGLLRD GKQVNVNLEL QQSSQNQVDS SSIFNGIEGA EMSNKGKDQG VVVNNVKTGT
     PAAQIGLKKG DVIIGANQQA VKNIAELRKV LDSKPSVLAL NIQRGDSTIY LLMQ
//

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