(data stored in ACNUC7421 zone)

SWISSPROT: Q3Z4T7_SHISS

ID   Q3Z4T7_SHISS            Unreviewed;      1049 AA.
AC   Q3Z4T7;
DT   27-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2005, sequence version 1.
DT   08-MAY-2019, entry version 76.
DE   RecName: Full=Efflux pump membrane transporter {ECO:0000256|RuleBase:RU364070};
GN   Name=acrB {ECO:0000313|EMBL:AAZ87225.1};
GN   OrderedLocusNames=SSON_0449 {ECO:0000313|EMBL:AAZ87225.1};
OS   Shigella sonnei (strain Ss046).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=300269 {ECO:0000313|EMBL:AAZ87225.1, ECO:0000313|Proteomes:UP000002529};
RN   [1] {ECO:0000313|EMBL:AAZ87225.1, ECO:0000313|Proteomes:UP000002529}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ss046 {ECO:0000313|EMBL:AAZ87225.1,
RC   ECO:0000313|Proteomes:UP000002529};
RX   PubMed=16275786; DOI=10.1093/nar/gki954;
RA   Yang F., Yang J., Zhang X., Chen L., Jiang Y., Yan Y., Tang X.,
RA   Wang J., Xiong Z., Dong J., Xue Y., Zhu Y., Xu X., Sun L., Chen S.,
RA   Nie H., Peng J., Xu J., Wang Y., Yuan Z., Wen Y., Yao Z., Shen Y.,
RA   Qiang B., Hou Y., Yu J., Jin Q.;
RT   "Genome dynamics and diversity of Shigella species, the etiologic
RT   agents of bacillary dysentery.";
RL   Nucleic Acids Res. 33:6445-6458(2005).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|RuleBase:RU364070}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU364070}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division
CC       (RND) (TC 2.A.6) family. {ECO:0000256|RuleBase:RU364070,
CC       ECO:0000256|SAAS:SAAS01080844}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU364070}.
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DR   EMBL; CP000038; AAZ87225.1; -; Genomic_DNA.
DR   EnsemblBacteria; AAZ87225; AAZ87225; SSON_0449.
DR   KEGG; ssn:SSON_0449; -.
DR   HOGENOM; HOG000158129; -.
DR   KO; K18138; -.
DR   OMA; LMYMSSS; -.
DR   BioCyc; SSON300269:G1GL2-515-MONOMER; -.
DR   Proteomes; UP000002529; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006855; P:drug transmembrane transport; IEA:InterPro.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR004764; HAE1.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
DR   TIGRFAMs; TIGR00915; 2A0602; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q3Z4T7.
DR   SWISS-2DPAGE; Q3Z4T7.
KW   Cell inner membrane {ECO:0000256|RuleBase:RU364070};
KW   Cell membrane {ECO:0000256|RuleBase:RU364070};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002529};
KW   Membrane {ECO:0000256|RuleBase:RU364070};
KW   Transmembrane {ECO:0000256|RuleBase:RU364070};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU364070};
KW   Transport {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM     12     32       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM    340    359       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM    366    390       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM    437    458       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM    470    493       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM    541    557       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM    875    892       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM    899    919       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM    925    946       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM    975    995       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM   1007   1029       Helical. {ECO:0000256|RuleBase:RU364070}.
SQ   SEQUENCE   1049 AA;  113560 MW;  1F200E3E1A734B39 CRC64;
     MPNFFIDRPI FAWVIAIIIM LAGGLAILKL PVAQYPTIAP PAVTISASYP GADAKTVQDT
     VTQVIEQNMN GIDNLMYMSS NSDSTGTVQI TLTFESGTDA DIAQVQVQNK LQLAMPLLPQ
     EVQQQGVSVE KSSSSFLMVV GVINTDGTMT QEDISDYVAA NMKDAISRTS GVGDVQLFGS
     QYAMRIWMNP NELNKFQLTP VDVITAIKAQ NAQVAAGQLG GTPPVKGQQL NASIIAQTRL
     TSTEEFGKIL LKVNQDGSRV LLRDVAKIEL GGENYDIIAE FNGQPASGLG IKLATGANAL
     DTAAAIRAEL AKMEPFFPSG LKIVYPYDTT PFVKISIHEV VKTLVEAIIL VFLVMYLFLQ
     NFRATLIPTI AVPVVLLGTF AVLAAFGFSI NTLTMFGMVL AIGLLVDDAI VVVENVERVM
     AEEGLPPKEA TRKSMGQIQG ALVGIAMVLS AVFVPMAFFG GSTGAIYRQF SITIVSAMAL
     SVLVALILTP ALCATMLKPI AKGDHGEGKK GFFGWFNRMF EKSTHHYTDS VGGILRSTGR
     YLVLYLIIVV GMAYLFVRLP SSFLPDEDQG VFMTMVQLPA GATQERTQKV LNEVTHYYLT
     KEKNNVESVF AVNGFGFAGR GQNTGIAFVS LKDWADRPGE ENKVEAITMR ATRAFSQIKD
     AMVFAFNLPA IVELGTATGF DFELIDQAGL GHEKLTQARN QLLAEAAKHP DMLTSVRPNG
     LEDTPQFKID IDQEKAQALG VSINDINTSL GAAWGGSYVN DFIDRGRVKK VYVMSEAKYR
     MLPDDIGDWY VRAADGQMVP FSAFSSSRWE YGSPRLERYN GLPSMEILGQ AAPGKSTGEA
     MELMEQLASK LPTGVGYDWT GMSYQERLSG NQAPSLYAIS LIVVFLCLAA LYESWSIPFS
     VMLVVPLGVI GALLAATFRG LTNDVYFQVG LLTTIGLSAK NAILIVEFAK DLMDKEGKGL
     IEATLDAVRM RLRPILMTSL AFILGVMPLV ISTGAGSGAQ NAVGTGVMGG MVTATVLAIF
     FVPVFFVVVR RRFSRKNEDI EHSHTVDHH
//

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