(data stored in ACNUC7421 zone)

SWISSPROT: Q3KJ59_PSEPF

ID   Q3KJ59_PSEPF            Unreviewed;       494 AA.
AC   Q3KJ59;
DT   08-NOV-2005, integrated into UniProtKB/TrEMBL.
DT   08-NOV-2005, sequence version 1.
DT   08-MAY-2019, entry version 111.
DE   RecName: Full=Sodium/proline symporter {ECO:0000256|RuleBase:RU366012};
DE   AltName: Full=Proline permease {ECO:0000256|RuleBase:RU366012};
GN   OrderedLocusNames=Pfl01_0453 {ECO:0000313|EMBL:ABA72197.1};
OS   Pseudomonas fluorescens (strain Pf0-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=205922 {ECO:0000313|EMBL:ABA72197.1, ECO:0000313|Proteomes:UP000002704};
RN   [1] {ECO:0000313|EMBL:ABA72197.1, ECO:0000313|Proteomes:UP000002704}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pf0-1 {ECO:0000313|EMBL:ABA72197.1,
RC   ECO:0000313|Proteomes:UP000002704};
RX   PubMed=19432983; DOI=10.1186/gb-2009-10-5-r51;
RA   Silby M.W., Cerdeno-Tarraga A.M., Vernikos G.S., Giddens S.R.,
RA   Jackson R.W., Preston G.M., Zhang X.X., Moon C.D., Gehrig S.M.,
RA   Godfrey S.A., Knight C.G., Malone J.G., Robinson Z., Spiers A.J.,
RA   Harris S., Challis G.L., Yaxley A.M., Harris D., Seeger K., Murphy L.,
RA   Rutter S., Squares R., Quail M.A., Saunders E., Mavromatis K.,
RA   Brettin T.S., Bentley S.D., Hothersall J., Stephens E., Thomas C.M.,
RA   Parkhill J., Levy S.B., Rainey P.B., Thomson N.R.;
RT   "Genomic and genetic analyses of diversity and plant interactions of
RT   Pseudomonas fluorescens.";
RL   Genome Biol. 10:R51.1-R51.16(2009).
CC   -!- FUNCTION: Catalyzes the sodium-dependent uptake of extracellular
CC       L-proline. {ECO:0000256|RuleBase:RU366012}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|RuleBase:RU366012}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU366012}.
CC   -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF)
CC       (TC 2.A.21) family. {ECO:0000256|RuleBase:RU366012}.
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DR   EMBL; CP000094; ABA72197.1; -; Genomic_DNA.
DR   RefSeq; WP_011332119.1; NC_007492.2.
DR   STRING; 205922.Pfl01_0453; -.
DR   EnsemblBacteria; ABA72197; ABA72197; Pfl01_0453.
DR   KEGG; pfo:Pfl01_0453; -.
DR   eggNOG; ENOG4105CK7; Bacteria.
DR   eggNOG; COG0591; LUCA.
DR   HOGENOM; HOG000282935; -.
DR   KO; K11928; -.
DR   OMA; CWTDLIQ; -.
DR   BioCyc; PFLU205922:G1G4S-458-MONOMER; -.
DR   Proteomes; UP000002704; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005298; F:proline:sodium symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0031402; F:sodium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0015824; P:proline transport; IEA:UniProtKB-UniRule.
DR   CDD; cd11475; SLC5sbd_PutP; 1.
DR   Gene3D; 1.20.1730.10; -; 1.
DR   InterPro; IPR038377; Na/Glc_symporter_sf.
DR   InterPro; IPR011851; Na/Pro_symporter.
DR   InterPro; IPR001734; Na/solute_symporter.
DR   InterPro; IPR018212; Na/solute_symporter_CS.
DR   Pfam; PF00474; SSF; 1.
DR   TIGRFAMs; TIGR02121; Na_Pro_sym; 1.
DR   TIGRFAMs; TIGR00813; sss; 1.
DR   PROSITE; PS00456; NA_SOLUT_SYMP_1; 1.
DR   PROSITE; PS00457; NA_SOLUT_SYMP_2; 1.
DR   PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q3KJ59.
DR   SWISS-2DPAGE; Q3KJ59.
KW   Amino-acid transport {ECO:0000256|RuleBase:RU366012};
KW   Cell inner membrane {ECO:0000256|RuleBase:RU366012};
KW   Cell membrane {ECO:0000256|SAAS:SAAS00735906};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002704};
KW   Ion transport {ECO:0000256|RuleBase:RU366012};
KW   Membrane {ECO:0000256|RuleBase:RU366012};
KW   Sodium {ECO:0000256|RuleBase:RU366012};
KW   Sodium transport {ECO:0000256|RuleBase:RU366012};
KW   Symport {ECO:0000256|RuleBase:RU366012};
KW   Transmembrane {ECO:0000256|RuleBase:RU366012};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU366012};
KW   Transport {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM      6     26       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM     76     94       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    124    152       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    164    185       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    192    212       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    232    249       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    275    296       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    325    350       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    371    391       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    403    422       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    429    447       Helical. {ECO:0000256|RuleBase:RU366012}.
FT   TRANSMEM    453    473       Helical. {ECO:0000256|RuleBase:RU366012}.
SQ   SEQUENCE   494 AA;  53029 MW;  AD8709D24685E803 CRC64;
     MSASNPTLIT FVIYIAAMVL IGFMAYRSTN NLSDYILGGR SLGSVVTALS AGASDMSGWL
     LMGLPGAIYM SGLSESWIAI GLIVGAYLNW LFVAGRLRVQ TEHNGDALTL PDYFSSRFED
     KSGLLRIISA VVILVFFTIY CASGIVAGAR LFESTFGMSY ETALWAGAAA TIAYTFVGGF
     LAVSWTDTVQ ATLMIFALLL TPIIVLLATG GVDTTFLAIE AQDPSNFDML KGTTFIGIIS
     LMGWGLGYFG QPHILARFMA ADSVKSIANA RRISMTWMIL CLGGTVAVGF FGIAYFSAHP
     EVAGPVTENH ERVFIELAKI LFNPWIAGVL LSAILAAVMS TLSCQLLVCS SALTEDFYKA
     FLRKSASQVE LVWVGRAMVL LVALIAIAMA ANPDNRVLGL VSYAWAGFGA AFGPVVLISV
     IWKKMTRDGA LAGILVGAIT VIVWKHFELL GLYEIIPGFI FASLAIYFVS LMGQPSAGMV
     QRFEAAEKDF HLNK
//

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