(data stored in ACNUC7421 zone)

SWISSPROT: Q3KIZ1_PSEPF

ID   Q3KIZ1_PSEPF            Unreviewed;       635 AA.
AC   Q3KIZ1;
DT   08-NOV-2005, integrated into UniProtKB/TrEMBL.
DT   08-NOV-2005, sequence version 1.
DT   08-MAY-2019, entry version 117.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|HAMAP-Rule:MF_00149, ECO:0000256|SAAS:SAAS01158470};
GN   Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN   OrderedLocusNames=Pfl01_0521 {ECO:0000313|EMBL:ABA72265.1};
OS   Pseudomonas fluorescens (strain Pf0-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=205922 {ECO:0000313|EMBL:ABA72265.1, ECO:0000313|Proteomes:UP000002704};
RN   [1] {ECO:0000313|EMBL:ABA72265.1, ECO:0000313|Proteomes:UP000002704}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pf0-1 {ECO:0000313|EMBL:ABA72265.1,
RC   ECO:0000313|Proteomes:UP000002704};
RX   PubMed=19432983; DOI=10.1186/gb-2009-10-5-r51;
RA   Silby M.W., Cerdeno-Tarraga A.M., Vernikos G.S., Giddens S.R.,
RA   Jackson R.W., Preston G.M., Zhang X.X., Moon C.D., Gehrig S.M.,
RA   Godfrey S.A., Knight C.G., Malone J.G., Robinson Z., Spiers A.J.,
RA   Harris S., Challis G.L., Yaxley A.M., Harris D., Seeger K., Murphy L.,
RA   Rutter S., Squares R., Quail M.A., Saunders E., Mavromatis K.,
RA   Brettin T.S., Bentley S.D., Hothersall J., Stephens E., Thomas C.M.,
RA   Parkhill J., Levy S.B., Rainey P.B., Thomson N.R.;
RT   "Genomic and genetic analyses of diversity and plant interactions of
RT   Pseudomonas fluorescens.";
RL   Genome Biol. 10:R51.1-R51.16(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in
CC       DNA. It is required for dam-dependent methyl-directed DNA mismatch
CC       repair. May act as a "molecular matchmaker", a protein that
CC       promotes the formation of a stable complex between two or more
CC       DNA-binding proteins in an ATP-dependent manner without itself
CC       being part of a final effector complex. {ECO:0000256|HAMAP-
CC       Rule:MF_00149, ECO:0000256|SAAS:SAAS01158472}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|HAMAP-Rule:MF_00149, ECO:0000256|SAAS:SAAS01076587}.
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DR   EMBL; CP000094; ABA72265.1; -; Genomic_DNA.
DR   RefSeq; WP_011332182.1; NC_007492.2.
DR   STRING; 205922.Pfl01_0521; -.
DR   EnsemblBacteria; ABA72265; ABA72265; Pfl01_0521.
DR   KEGG; pfo:Pfl01_0521; -.
DR   eggNOG; ENOG4105DC6; Bacteria.
DR   eggNOG; COG0323; LUCA.
DR   HOGENOM; HOG000256551; -.
DR   KO; K03572; -.
DR   OMA; QHIAHER; -.
DR   BioCyc; PFLU205922:G1G4S-526-MONOMER; -.
DR   Proteomes; UP000002704; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATPase activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   CDD; cd00075; HATPase_c; 1.
DR   Gene3D; 2.30.42.20; -; 1.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q3KIZ1.
DR   SWISS-2DPAGE; Q3KIZ1.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002704};
KW   DNA damage {ECO:0000256|HAMAP-Rule:MF_00149,
KW   ECO:0000256|SAAS:SAAS00440831};
KW   DNA repair {ECO:0000256|HAMAP-Rule:MF_00149,
KW   ECO:0000256|SAAS:SAAS00020747}.
FT   DOMAIN      219    337       DNA_mis_repair. {ECO:0000259|SMART:
FT                                SM01340}.
FT   DOMAIN      448    591       MutL_C. {ECO:0000259|SMART:SM00853}.
SQ   SEQUENCE   635 AA;  70066 MW;  F26D0C72B76EBD09 CRC64;
     MNQVLNAARI ELLSPRLANQ IAAGEVVERP ASVIKELLEN SLDSGAKRID VDVEQGGVKL
     LRVRDDGSGI SADDLPLALA RHATSKIRNL EDLEQVMSLG FRGEALASIS SVARLTLTSR
     TRDADQAWQV ETEGRDMAPR VQPAAHPVGT SVEVRDLFFN TPARRKFLKT EKTEFDHLQE
     VIKRLALARF DVAFHLRHNG KTILSLHEAH DDAARARRVA AICGSGFLEQ ALPIEIERNG
     LHLWGWVGLP TFNRSQADLQ YFFVNGRAVR DKLVAHAVRQ AYRDVLFNGR HPTFALFFEV
     DPAAVDVNVH PTKHEVRFRD GRMVHDFLYG TLHRALGDVR PEDQLAGSVT TAIVRPTGLE
     AGEFGPQGEM RLAANALLEQ PQAQPAFNTA SGASAGGAYQ YQYTPRPQST VPVAEAQAAY
     REFFAPLPEA NANALPAGQE DIPPLGYALA QLKGIYILSE NAQGLVLVDM HAAHERIMYE
     RLKIAMASEG LSGQPLLVPE SLAVSQREAD CAEEHAAWFQ RLGFELQRLG PETLAIRQIP
     ALLKQAEANR LVGDVLSDLM EYGTSDRIQA HLNELLGTMA CHGAIRANRR LALPEMNGLL
     RDMENTERSG QCNHGRPTWT QLGLDDLDKL FLRGR
//

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