(data stored in ACNUC7421 zone)

SWISSPROT: HISZ_PSEPF

ID   HISZ_PSEPF              Reviewed;         395 AA.
AC   Q3KIY5;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   08-MAY-2019, entry version 93.
DE   RecName: Full=ATP phosphoribosyltransferase regulatory subunit {ECO:0000255|HAMAP-Rule:MF_00125};
GN   Name=hisZ {ECO:0000255|HAMAP-Rule:MF_00125};
GN   OrderedLocusNames=Pfl01_0527;
OS   Pseudomonas fluorescens (strain Pf0-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=205922;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pf0-1;
RX   PubMed=19432983; DOI=10.1186/gb-2009-10-5-r51;
RA   Silby M.W., Cerdeno-Tarraga A.M., Vernikos G.S., Giddens S.R.,
RA   Jackson R.W., Preston G.M., Zhang X.-X., Moon C.D., Gehrig S.M.,
RA   Godfrey S.A.C., Knight C.G., Malone J.G., Robinson Z., Spiers A.J.,
RA   Harris S., Challis G.L., Yaxley A.M., Harris D., Seeger K., Murphy L.,
RA   Rutter S., Squares R., Quail M.A., Saunders E., Mavromatis K.,
RA   Brettin T.S., Bentley S.D., Hothersall J., Stephens E., Thomas C.M.,
RA   Parkhill J., Levy S.B., Rainey P.B., Thomson N.R.;
RT   "Genomic and genetic analyses of diversity and plant interactions of
RT   Pseudomonas fluorescens.";
RL   Genome Biol. 10:R51.1-R51.16(2009).
CC   -!- FUNCTION: Required for the first step of histidine biosynthesis.
CC       May allow the feedback regulation of ATP phosphoribosyltransferase
CC       activity by histidine. {ECO:0000255|HAMAP-Rule:MF_00125}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-
CC       histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.
CC       {ECO:0000255|HAMAP-Rule:MF_00125}.
CC   -!- SUBUNIT: Heteromultimer composed of HisG and HisZ subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00125}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00125}.
CC   -!- MISCELLANEOUS: This function is generally fulfilled by the C-
CC       terminal part of HisG, which is missing in some bacteria such as
CC       this one.
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase
CC       family. HisZ subfamily. {ECO:0000255|HAMAP-Rule:MF_00125}.
DR   EMBL; CP000094; ABA72271.1; -; Genomic_DNA.
DR   RefSeq; WP_011332186.1; NC_007492.2.
DR   SMR; Q3KIY5; -.
DR   STRING; 205922.Pfl01_0527; -.
DR   PRIDE; Q3KIY5; -.
DR   EnsemblBacteria; ABA72271; ABA72271; Pfl01_0527.
DR   KEGG; pfo:Pfl01_0527; -.
DR   eggNOG; ENOG4105C49; Bacteria.
DR   eggNOG; COG3705; LUCA.
DR   HOGENOM; HOG000018074; -.
DR   KO; K02502; -.
DR   OMA; GYELVMP; -.
DR   BioCyc; PFLU205922:G1G4S-532-MONOMER; -.
DR   UniPathway; UPA00031; UER00006.
DR   Proteomes; UP000002704; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00773; HisRS-like_core; 1.
DR   HAMAP; MF_00125; HisZ; 1.
DR   InterPro; IPR041715; HisRS-like_core.
DR   InterPro; IPR004516; HisRS/HisZ.
DR   InterPro; IPR004517; HisZ.
DR   PANTHER; PTHR43707; PTHR43707; 1.
DR   Pfam; PF13393; tRNA-synt_His; 1.
DR   PIRSF; PIRSF001549; His-tRNA_synth; 1.
DR   TIGRFAMs; TIGR00443; hisZ_biosyn_reg; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q3KIY5.
DR   SWISS-2DPAGE; Q3KIY5.
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm;
KW   Histidine biosynthesis.
FT   CHAIN         1    395       ATP phosphoribosyltransferase regulatory
FT                                subunit.
FT                                /FTId=PRO_0000242848.
SQ   SEQUENCE   395 AA;  42851 MW;  273C8AE8C8F51760 CRC64;
     MATVDRWLLP DGIEEVLPPE AARIEVARRQ VLDLFQSWGY EFVVTPHIEY LESLLTGAGQ
     DLDLRTFKVI DPQSGRQMGF RADITPQVAR IDAHTLRREG PSRLCYAGSV LHAQPRALSS
     SRSPIQLGAE LYGDASPSSD VEVISLMLAM LQLADVPDVH MDLGHVGIYR GLAQAAGLSG
     EVEQQLFDAL QRKAIDEVIT LTEGLPADLS GMLRALVDLC GGREVLSAAR ERLANAPAPV
     LAALEDLLAI AERLSVRFPE LPLYFDLGEL RGYHYHTGVV FAVFVPGVGQ SIAQGGRYDD
     IGADFGRARP ATGFSTDLKT LVTLGRAEIE LPSGGIWMPD STDAALWQQV CQLRSEGQRV
     VQALPGQPLA AARDADCDRQ LIQQNGLWQV SPLAS
//

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