(data stored in ACNUC7421 zone)

SWISSPROT: Q3KIQ6_PSEPF

ID   Q3KIQ6_PSEPF            Unreviewed;       244 AA.
AC   Q3KIQ6;
DT   08-NOV-2005, integrated into UniProtKB/TrEMBL.
DT   08-NOV-2005, sequence version 1.
DT   08-MAY-2019, entry version 101.
DE   RecName: Full=Precorrin-2 C(20)-methyltransferase {ECO:0000256|PIRNR:PIRNR036427};
DE            EC=2.1.1.130 {ECO:0000256|PIRNR:PIRNR036427};
GN   OrderedLocusNames=Pfl01_0606 {ECO:0000313|EMBL:ABA72350.1};
OS   Pseudomonas fluorescens (strain Pf0-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=205922 {ECO:0000313|EMBL:ABA72350.1, ECO:0000313|Proteomes:UP000002704};
RN   [1] {ECO:0000313|EMBL:ABA72350.1, ECO:0000313|Proteomes:UP000002704}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pf0-1 {ECO:0000313|EMBL:ABA72350.1,
RC   ECO:0000313|Proteomes:UP000002704};
RX   PubMed=19432983; DOI=10.1186/gb-2009-10-5-r51;
RA   Silby M.W., Cerdeno-Tarraga A.M., Vernikos G.S., Giddens S.R.,
RA   Jackson R.W., Preston G.M., Zhang X.X., Moon C.D., Gehrig S.M.,
RA   Godfrey S.A., Knight C.G., Malone J.G., Robinson Z., Spiers A.J.,
RA   Harris S., Challis G.L., Yaxley A.M., Harris D., Seeger K., Murphy L.,
RA   Rutter S., Squares R., Quail M.A., Saunders E., Mavromatis K.,
RA   Brettin T.S., Bentley S.D., Hothersall J., Stephens E., Thomas C.M.,
RA   Parkhill J., Levy S.B., Rainey P.B., Thomson N.R.;
RT   "Genomic and genetic analyses of diversity and plant interactions of
RT   Pseudomonas fluorescens.";
RL   Genome Biol. 10:R51.1-R51.16(2009).
CC   -!- FUNCTION: Methylates precorrin-2 at the C-20 position to produce
CC       precorrin-3A. {ECO:0000256|PIRNR:PIRNR036427}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=precorrin-2 + S-adenosyl-L-methionine = H(+) + precorrin-
CC         3A + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:16841,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:58561,
CC         ChEBI:CHEBI:58827, ChEBI:CHEBI:59789; EC=2.1.1.130;
CC         Evidence={ECO:0000256|PIRNR:PIRNR036427};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR036427}.
CC   -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC       {ECO:0000256|PIRNR:PIRNR036427, ECO:0000256|RuleBase:RU003960}.
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DR   EMBL; CP000094; ABA72350.1; -; Genomic_DNA.
DR   STRING; 205922.Pfl01_0606; -.
DR   EnsemblBacteria; ABA72350; ABA72350; Pfl01_0606.
DR   KEGG; pfo:Pfl01_0606; -.
DR   eggNOG; ENOG4105DVK; Bacteria.
DR   eggNOG; COG2243; LUCA.
DR   HOGENOM; HOG000291191; -.
DR   KO; K03394; -.
DR   OMA; GRRLFME; -.
DR   Proteomes; UP000002704; Chromosome.
DR   GO; GO:0030788; F:precorrin-2 C20-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0055114; P:oxidation-reduction process; IEA:InterPro.
DR   CDD; cd11645; Precorrin_2_C20_MT; 1.
DR   Gene3D; 3.30.950.10; -; 1.
DR   Gene3D; 3.40.1010.10; -; 1.
DR   InterPro; IPR000878; 4pyrrol_Mease.
DR   InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR   InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR   InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR   InterPro; IPR012382; CobI/CbiL.
DR   InterPro; IPR006364; CobI/CbiL/CobIJ_dom.
DR   InterPro; IPR003043; Uropor_MeTrfase_CS.
DR   Pfam; PF00590; TP_methylase; 1.
DR   PIRSF; PIRSF036427; Precrrn-2_mtase; 1.
DR   SUPFAM; SSF53790; SSF53790; 1.
DR   TIGRFAMs; TIGR01467; cobI_cbiL; 1.
DR   PROSITE; PS00840; SUMT_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q3KIQ6.
DR   SWISS-2DPAGE; Q3KIQ6.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002704};
KW   Methyltransferase {ECO:0000256|RuleBase:RU003960,
KW   ECO:0000256|SAAS:SAAS00467449, ECO:0000313|EMBL:ABA72350.1};
KW   S-adenosyl-L-methionine {ECO:0000256|SAAS:SAAS00467481};
KW   Transferase {ECO:0000256|RuleBase:RU003960,
KW   ECO:0000256|SAAS:SAAS00467429, ECO:0000313|EMBL:ABA72350.1}.
FT   DOMAIN        7    219       TP_methylase. {ECO:0000259|Pfam:PF00590}.
SQ   SEQUENCE   244 AA;  26545 MW;  EEEC485119BE72D8 CRC64;
     MMQAQGRLIG LGVGPGDPEL ITVKALRLLR ESPVVAYFVA KGKKGNAFGI IEAHLQDAQN
     LLPLVYPVTT EVLPAPLSYE QVISDFYDDA AEEVAAHLDA GRDVAVICEG DPFFYGSYMY
     LHDRLAGRYE AEVVPGVCSM LGGASVLGAP LVYRNQSLSV LSGVLPHEEL KRRLADADAA
     VIMKLGRNFP KVRDVLAELG LAERALYVER ATMANQKIVS LDEVEPMSSP YFSLIIVPGE
     RWQG
//

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