(data stored in ACNUC7421 zone)

SWISSPROT: Q2ILY3_ANADE

ID   Q2ILY3_ANADE            Unreviewed;       441 AA.
AC   Q2ILY3;
DT   07-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   07-MAR-2006, sequence version 1.
DT   08-MAY-2019, entry version 72.
DE   RecName: Full=Phenylacetate-coenzyme A ligase {ECO:0000256|PIRNR:PIRNR006444};
DE            EC=6.2.1.30 {ECO:0000256|PIRNR:PIRNR006444};
DE   AltName: Full=Phenylacetyl-CoA ligase {ECO:0000256|PIRNR:PIRNR006444};
GN   OrderedLocusNames=Adeh_0036 {ECO:0000313|EMBL:ABC79814.1};
OS   Anaeromyxobacter dehalogenans (strain 2CP-C).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Anaeromyxobacteraceae; Anaeromyxobacter.
OX   NCBI_TaxID=290397 {ECO:0000313|EMBL:ABC79814.1, ECO:0000313|Proteomes:UP000001935};
RN   [1] {ECO:0000313|EMBL:ABC79814.1, ECO:0000313|Proteomes:UP000001935}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2CP-C {ECO:0000313|EMBL:ABC79814.1,
RC   ECO:0000313|Proteomes:UP000001935};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C.,
RA   Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S.,
RA   Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001935}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2CP-C {ECO:0000313|Proteomes:UP000001935};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C.,
RA   Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S.,
RA   Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the activation of phenylacetic acid (PA) to
CC       phenylacetyl-CoA (PA-CoA). {ECO:0000256|PIRNR:PIRNR006444}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-phenylacetate + ATP + CoA = AMP + diphosphate +
CC         phenylacetyl-CoA; Xref=Rhea:RHEA:20956, ChEBI:CHEBI:18401,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57390, ChEBI:CHEBI:456215; EC=6.2.1.30;
CC         Evidence={ECO:0000256|PIRNR:PIRNR006444};
CC   -!- PATHWAY: Aromatic compound metabolism; phenylacetate degradation.
CC       {ECO:0000256|PIRNR:PIRNR006444}.
CC   -!- SIMILARITY: Belongs to the phenylacetyl-CoA ligase family.
CC       {ECO:0000256|PIRNR:PIRNR006444}.
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DR   EMBL; CP000251; ABC79814.1; -; Genomic_DNA.
DR   RefSeq; WP_011419097.1; NC_007760.1.
DR   STRING; 290397.Adeh_0036; -.
DR   EnsemblBacteria; ABC79814; ABC79814; Adeh_0036.
DR   KEGG; ade:Adeh_0036; -.
DR   eggNOG; ENOG4105DZS; Bacteria.
DR   eggNOG; COG1541; LUCA.
DR   HOGENOM; HOG000197614; -.
DR   KO; K01912; -.
DR   OMA; IQNTHGY; -.
DR   BioCyc; ADEH290397:G1G5W-38-MONOMER; -.
DR   UniPathway; UPA00930; -.
DR   Proteomes; UP000001935; Chromosome.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0047475; F:phenylacetate-CoA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0010124; P:phenylacetate catabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.12780; -; 1.
DR   InterPro; IPR028154; AMP-dep_Lig_C.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR042099; AMP-dep_Synthh-like_sf.
DR   InterPro; IPR011880; PA_CoA_ligase.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF14535; AMP-binding_C_2; 1.
DR   PIRSF; PIRSF006444; PaaK; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q2ILY3.
DR   SWISS-2DPAGE; Q2ILY3.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001935};
KW   Ligase {ECO:0000256|PIRNR:PIRNR006444, ECO:0000313|EMBL:ABC79814.1};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR006444};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001935}.
FT   DOMAIN       88    292       AMP-binding. {ECO:0000259|Pfam:PF00501}.
FT   DOMAIN      340    436       AMP-binding_C_2. {ECO:0000259|Pfam:
FT                                PF14535}.
SQ   SEQUENCE   441 AA;  48677 MW;  F92BD3141A5820E7 CRC64;
     MARFALENRI LDPEETLDRD ALAALQGRRL AETVRRARAV PHHRKALERA GVRDEDLRGP
     DDVRRLPFTV KDDLRQSYPL GLLAVPREQV VRIHGSSGTT GRPTFVAYTR RDLDTWTGLV
     ARFLVAGGLR PEHTVHVAFG YGLFTGGFGL HYGIERVGAA VVPSGGGNTP RQVRLICDLS
     ADVLISTPSY ALHVGEVARA EGLKPGDLPL RYGHFGGEPW TEEMRGEIER SLGILAFNNY
     GLSEVIGPGV AGECPARDGM HVQEDHFIVE CLDPVTLEPV PDGEVGELVF TSLTKEAMPV
     LRYRTRDLAA LDRSPCPCGR TGVRMSRVRG RSDDMLIIRG VNVFPSQVEE ALLRVEGTAP
     HYLIEVSRPG ALDEAVVKVE VRPEDFRDEM REMVGLRDRI DREIHAVTGI RMIVELVAPN
     TLERSAGKAR RVLDHRKVGP A
//

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