(data stored in ACNUC7421 zone)

SWISSPROT: Q2IM03_ANADE

ID   Q2IM03_ANADE            Unreviewed;       339 AA.
AC   Q2IM03;
DT   07-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   07-MAR-2006, sequence version 1.
DT   08-MAY-2019, entry version 91.
DE   RecName: Full=Pseudouridine synthase {ECO:0000256|RuleBase:RU362028};
DE            EC=5.4.99.- {ECO:0000256|RuleBase:RU362028};
GN   OrderedLocusNames=Adeh_0056 {ECO:0000313|EMBL:ABC79834.1};
OS   Anaeromyxobacter dehalogenans (strain 2CP-C).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Anaeromyxobacteraceae; Anaeromyxobacter.
OX   NCBI_TaxID=290397 {ECO:0000313|EMBL:ABC79834.1, ECO:0000313|Proteomes:UP000001935};
RN   [1] {ECO:0000313|EMBL:ABC79834.1, ECO:0000313|Proteomes:UP000001935}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2CP-C {ECO:0000313|EMBL:ABC79834.1,
RC   ECO:0000313|Proteomes:UP000001935};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C.,
RA   Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S.,
RA   Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001935}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2CP-C {ECO:0000313|Proteomes:UP000001935};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C.,
RA   Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S.,
RA   Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil.
CC       {ECO:0000256|RuleBase:RU362028}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a uridine in RNA = a psi-uridine in RNA;
CC         Xref=Rhea:RHEA:48348, Rhea:RHEA-COMP:12068, Rhea:RHEA-
CC         COMP:12069, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC         Evidence={ECO:0000256|RuleBase:RU362028};
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000256|RuleBase:RU362028, ECO:0000256|SAAS:SAAS01177972}.
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DR   EMBL; CP000251; ABC79834.1; -; Genomic_DNA.
DR   RefSeq; WP_011419117.1; NC_007760.1.
DR   STRING; 290397.Adeh_0056; -.
DR   EnsemblBacteria; ABC79834; ABC79834; Adeh_0056.
DR   KEGG; ade:Adeh_0056; -.
DR   eggNOG; ENOG4105EI2; Bacteria.
DR   eggNOG; COG0564; LUCA.
DR   HOGENOM; HOG000275914; -.
DR   KO; K06179; -.
DR   OMA; PKTHVYR; -.
DR   BioCyc; ADEH290397:G1G5W-58-MONOMER; -.
DR   Proteomes; UP000001935; Chromosome.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   CDD; cd02869; PseudoU_synth_RluCD_like; 1.
DR   CDD; cd00165; S4; 1.
DR   Gene3D; 3.10.290.10; -; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006225; PsdUridine_synth_RluC/D.
DR   InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   InterPro; IPR002942; S4_RNA-bd.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   TIGRFAMs; TIGR00005; rluA_subfam; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
DR   PROSITE; PS50889; S4; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q2IM03.
DR   SWISS-2DPAGE; Q2IM03.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001935};
KW   Isomerase {ECO:0000256|RuleBase:RU362028,
KW   ECO:0000256|SAAS:SAAS00999454, ECO:0000313|EMBL:ABC79834.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001935};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00182,
KW   ECO:0000256|SAAS:SAAS00999393}.
FT   DOMAIN       13     73       S4 RNA-binding. {ECO:0000259|PROSITE:
FT                                PS50889}.
SQ   SEQUENCE   339 AA;  36937 MW;  26DF64E0C12C8F52 CRC64;
     MIQLTVSADA AGQRLDKLVR KALRDVPLSH VYKMFRTRKV RVNGARGKAD QVVAEGDVVV
     IRGDEERLLA KAAPAAPGGA PRVTFGVLHE DADLLAVDKP AGLAAHPGTG IEGATLVEMA
     RGYLKTPDDL PPTEFKPSPA HRLDRDTSGV VLVAKHRKAM VRLGETFTTG EGVHKTYLAL
     VKGKMPREAG TIDLPLSEHE QTSKSKAMRG VNFQEALTRW KVVSAAKEIS LLAVTIETGR
     THQIRRHLEA VGHPVAGDRR YGDFAFNRTA RTRWGLRRMG LHAWRLEVPH PLTGAPLRLE
     APFPAELAEV LSRANLKLPA SPTGAHAPGA RREGPHRER
//

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