(data stored in ACNUC7421 zone)

SWISSPROT: Q2IME3_ANADE

ID   Q2IME3_ANADE            Unreviewed;       299 AA.
AC   Q2IME3;
DT   07-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   07-MAR-2006, sequence version 1.
DT   08-MAY-2019, entry version 85.
DE   RecName: Full=Pseudouridine synthase {ECO:0000256|RuleBase:RU362028};
DE            EC=5.4.99.- {ECO:0000256|RuleBase:RU362028};
GN   OrderedLocusNames=Adeh_0195 {ECO:0000313|EMBL:ABC79972.1};
OS   Anaeromyxobacter dehalogenans (strain 2CP-C).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Anaeromyxobacteraceae; Anaeromyxobacter.
OX   NCBI_TaxID=290397 {ECO:0000313|EMBL:ABC79972.1, ECO:0000313|Proteomes:UP000001935};
RN   [1] {ECO:0000313|EMBL:ABC79972.1, ECO:0000313|Proteomes:UP000001935}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2CP-C {ECO:0000313|EMBL:ABC79972.1,
RC   ECO:0000313|Proteomes:UP000001935};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C.,
RA   Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S.,
RA   Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001935}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2CP-C {ECO:0000313|Proteomes:UP000001935};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C.,
RA   Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S.,
RA   Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil.
CC       {ECO:0000256|RuleBase:RU362028}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a uridine in RNA = a psi-uridine in RNA;
CC         Xref=Rhea:RHEA:48348, Rhea:RHEA-COMP:12068, Rhea:RHEA-
CC         COMP:12069, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC         Evidence={ECO:0000256|RuleBase:RU362028};
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000256|RuleBase:RU362028, ECO:0000256|SAAS:SAAS01177972}.
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DR   EMBL; CP000251; ABC79972.1; -; Genomic_DNA.
DR   RefSeq; WP_011419255.1; NC_007760.1.
DR   STRING; 290397.Adeh_0195; -.
DR   EnsemblBacteria; ABC79972; ABC79972; Adeh_0195.
DR   KEGG; ade:Adeh_0195; -.
DR   eggNOG; ENOG4105DR9; Bacteria.
DR   eggNOG; COG0564; LUCA.
DR   HOGENOM; HOG000275914; -.
DR   OMA; LNYKGAD; -.
DR   BioCyc; ADEH290397:G1G5W-202-MONOMER; -.
DR   Proteomes; UP000001935; Chromosome.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   CDD; cd02869; PseudoU_synth_RluCD_like; 1.
DR   CDD; cd00165; S4; 1.
DR   Gene3D; 3.10.290.10; -; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006225; PsdUridine_synth_RluC/D.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   InterPro; IPR002942; S4_RNA-bd.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   Pfam; PF01479; S4; 1.
DR   SMART; SM00363; S4; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   TIGRFAMs; TIGR00005; rluA_subfam; 1.
DR   PROSITE; PS50889; S4; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q2IME3.
DR   SWISS-2DPAGE; Q2IME3.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001935};
KW   Isomerase {ECO:0000256|RuleBase:RU362028,
KW   ECO:0000256|SAAS:SAAS00999454};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001935};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00182,
KW   ECO:0000256|SAAS:SAAS00999393}.
FT   DOMAIN       15     87       S4 RNA-binding. {ECO:0000259|PROSITE:
FT                                PS50889}.
SQ   SEQUENCE   299 AA;  31753 MW;  FDDB6B260D269D29 CRC64;
     MRRLTLLVPD VDRYERIDRF IAARGGISRG LARRAIEAGG VFVDGRRCKV AGRTLTPGQQ
     VVVNLEEGGR AASAPAALGR ERLLYADADL CAVDKPAGVP AQPTLTTDRG ALPELVSALL
     GAPVTLVHRL DRETSGVTVF ARTREAAAAL AEAFRTGAPE KTYLALCARA PSPAEGRVAL
     ALGKDPARPG LRRVDPAGDP AATRYRTLRE APGGAQVEAR PETGRTHQIR VHLAALGAPL
     LGDARYGGPR RVGEVAVPRV MLHAARLELP HPVTGVRMVF EAEPPDDFRA VEAALVPER
//

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