(data stored in ACNUC7421 zone)

SWISSPROT: RNH2_ANADE

ID   RNH2_ANADE              Reviewed;         283 AA.
AC   Q2IMM4;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   08-MAY-2019, entry version 75.
DE   RecName: Full=Ribonuclease HII {ECO:0000255|HAMAP-Rule:MF_00052};
DE            Short=RNase HII {ECO:0000255|HAMAP-Rule:MF_00052};
DE            EC=3.1.26.4 {ECO:0000255|HAMAP-Rule:MF_00052};
GN   Name=rnhB {ECO:0000255|HAMAP-Rule:MF_00052};
GN   OrderedLocusNames=Adeh_0278;
OS   Anaeromyxobacter dehalogenans (strain 2CP-C).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Anaeromyxobacteraceae; Anaeromyxobacter.
OX   NCBI_TaxID=290397;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2CP-C;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C.,
RA   Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S.,
RA   Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Endonuclease that specifically degrades the RNA of RNA-
CC       DNA hybrids. {ECO:0000255|HAMAP-Rule:MF_00052}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.;
CC         EC=3.1.26.4; Evidence={ECO:0000255|HAMAP-Rule:MF_00052};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00052};
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00052};
CC       Note=Manganese or magnesium. Binds 1 divalent metal ion per
CC       monomer in the absence of substrate. May bind a second metal ion
CC       after substrate binding. {ECO:0000255|HAMAP-Rule:MF_00052};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00052}.
CC   -!- SIMILARITY: Belongs to the RNase HII family. {ECO:0000255|HAMAP-
CC       Rule:MF_00052}.
DR   EMBL; CP000251; ABC80054.1; -; Genomic_DNA.
DR   RefSeq; WP_011419337.1; NC_007760.1.
DR   SMR; Q2IMM4; -.
DR   STRING; 290397.Adeh_0278; -.
DR   EnsemblBacteria; ABC80054; ABC80054; Adeh_0278.
DR   KEGG; ade:Adeh_0278; -.
DR   eggNOG; ENOG4108UH2; Bacteria.
DR   eggNOG; COG0164; LUCA.
DR   HOGENOM; HOG000100288; -.
DR   KO; K03470; -.
DR   OMA; NILHASM; -.
DR   BioCyc; ADEH290397:G1G5W-285-MONOMER; -.
DR   Proteomes; UP000001935; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006401; P:RNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd07182; RNase_HII_bacteria_HII_like; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   HAMAP; MF_00052_B; RNase_HII_B; 1.
DR   InterPro; IPR022898; RNase_HII.
DR   InterPro; IPR001352; RNase_HII/HIII.
DR   InterPro; IPR024567; RNase_HII/HIII_dom.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR10954; PTHR10954; 1.
DR   PANTHER; PTHR10954:SF18; PTHR10954:SF18; 1.
DR   Pfam; PF01351; RNase_HII; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q2IMM4.
DR   SWISS-2DPAGE; Q2IMM4.
KW   Complete proteome; Cytoplasm; Endonuclease; Hydrolase; Manganese;
KW   Metal-binding; Nuclease; Reference proteome.
FT   CHAIN         1    283       Ribonuclease HII.
FT                                /FTId=PRO_0000235693.
FT   METAL        84     84       Divalent metal cation.
FT                                {ECO:0000255|HAMAP-Rule:MF_00052}.
FT   METAL        85     85       Divalent metal cation.
FT                                {ECO:0000255|HAMAP-Rule:MF_00052}.
FT   METAL       176    176       Divalent metal cation.
FT                                {ECO:0000255|HAMAP-Rule:MF_00052}.
SQ   SEQUENCE   283 AA;  31107 MW;  9DC8A68CD5CE7A44 CRC64;
     MRPEDLARLS VAELRTRLLD RGEALGDACE AALEADPRAG AREVLRLVRK RRRENRAEGQ
     RLRHLLRYEA ELWERGLVHV AGVDEAGMAP LAGPVVAGAC VLPRDYRPRG IDDSKQLDRA
     ERERLAEDIK RNAVCWAVAR AEVEEIDRLN VYWAGMLALR RAVDGLSARP EHLLVDARKL
     PDLPFPQTPI VHGDALSLTI AAASILAKTA RDALMAELDL AHPGYGFARH KGYPTAEHFD
     ALGRLGACPI HRRSFAPVRV ALGLEPAQGD LFALAEAAVA EDD
//

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