(data stored in ACNUC7421 zone)

SWISSPROT: Q2IN02_ANADE

ID   Q2IN02_ANADE            Unreviewed;       435 AA.
AC   Q2IN02;
DT   07-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   07-MAR-2006, sequence version 1.
DT   08-MAY-2019, entry version 89.
DE   SubName: Full=3-ketoacyl-CoA thiolase {ECO:0000313|EMBL:ABC80183.1};
DE            EC=2.3.1.16 {ECO:0000313|EMBL:ABC80183.1};
GN   OrderedLocusNames=Adeh_0407 {ECO:0000313|EMBL:ABC80183.1};
OS   Anaeromyxobacter dehalogenans (strain 2CP-C).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Anaeromyxobacteraceae; Anaeromyxobacter.
OX   NCBI_TaxID=290397 {ECO:0000313|EMBL:ABC80183.1, ECO:0000313|Proteomes:UP000001935};
RN   [1] {ECO:0000313|Proteomes:UP000001935}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2CP-C {ECO:0000313|Proteomes:UP000001935};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C.,
RA   Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S.,
RA   Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the thiolase family.
CC       {ECO:0000256|RuleBase:RU003557}.
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DR   EMBL; CP000251; ABC80183.1; -; Genomic_DNA.
DR   RefSeq; WP_011419466.1; NC_007760.1.
DR   STRING; 290397.Adeh_0407; -.
DR   EnsemblBacteria; ABC80183; ABC80183; Adeh_0407.
DR   KEGG; ade:Adeh_0407; -.
DR   eggNOG; ENOG4105CHU; Bacteria.
DR   eggNOG; COG0183; LUCA.
DR   HOGENOM; HOG000012240; -.
DR   KO; K00632; -.
DR   OMA; AWESEDY; -.
DR   BioCyc; ADEH290397:G1G5W-417-MONOMER; -.
DR   Proteomes; UP000001935; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0003988; F:acetyl-CoA C-acyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:InterPro.
DR   CDD; cd00751; thiolase; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   InterPro; IPR012806; Ac-CoA_C-AcTrfase_FadI.
DR   InterPro; IPR002155; Thiolase.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR020610; Thiolase_AS.
DR   InterPro; IPR020617; Thiolase_C.
DR   InterPro; IPR020613; Thiolase_CS.
DR   InterPro; IPR020616; Thiolase_N.
DR   PANTHER; PTHR18919:SF113; PTHR18919:SF113; 1.
DR   Pfam; PF02803; Thiolase_C; 1.
DR   Pfam; PF00108; Thiolase_N; 1.
DR   PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   TIGRFAMs; TIGR01930; AcCoA-C-Actrans; 1.
DR   PROSITE; PS00737; THIOLASE_2; 1.
DR   PROSITE; PS00099; THIOLASE_3; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q2IN02.
DR   SWISS-2DPAGE; Q2IN02.
KW   Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW   ECO:0000313|EMBL:ABC80183.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001935};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001935};
KW   Transferase {ECO:0000256|RuleBase:RU003557,
KW   ECO:0000313|EMBL:ABC80183.1}.
FT   DOMAIN       14    287       Thiolase_N. {ECO:0000259|Pfam:PF00108}.
FT   DOMAIN      295    434       Thiolase_C. {ECO:0000259|Pfam:PF02803}.
FT   ACT_SITE     97     97       Acyl-thioester intermediate.
FT                                {ECO:0000256|PIRSR:PIRSR000429-1}.
FT   ACT_SITE    391    391       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000429-1}.
FT   ACT_SITE    421    421       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000429-1}.
SQ   SEQUENCE   435 AA;  46017 MW;  C80968000B56561F CRC64;
     MGMNGSPPPG RRAAVVAGLR TPFVKAGTDF KDLSATELGA LLVNELVVRS GLPPNAFDSV
     VFGQVIPSPT VTLIGREMVL RTQLPRSVQA HTVARACATS IQAATDVADQ IRLGHSDCAI
     AGGAESVSDA PIFASRPLAQ ALVELSRART LADRARILAG LRPRDFTPTP PALKEPTTGL
     TMGESAEKMA QVNGISRAAQ DRLAYESHRR AAEAWDAGRF DEEVMHVPVP PRYDHVAARD
     NIVRKDTTVE ALAKLRPVFD RRYGTITAGN ASPLTDGAAA LVLMSEERAK ALGIRPLGFV
     KAYAYAALDP RDQLLQGPAY AAPVALERAG LRLADMDLVD MHEAFAAQVL SNLQAFASKD
     FAERELGRSA PLGEVDPAKL NVNGGSIALG HPFAATGARM ILQTLRELGR RGGQHALLTV
     CAAGGLGAAV VLERE
//

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