(data stored in ACNUC7421 zone)

SWISSPROT: PHNC_ANADE

ID   PHNC_ANADE              Reviewed;         498 AA.
AC   Q2IN45;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   08-MAY-2019, entry version 87.
DE   RecName: Full=Phosphonates import ATP-binding protein PhnC {ECO:0000255|HAMAP-Rule:MF_01713};
DE            EC=7.3.2.2 {ECO:0000255|HAMAP-Rule:MF_01713};
GN   Name=phnC {ECO:0000255|HAMAP-Rule:MF_01713};
GN   OrderedLocusNames=Adeh_0455;
OS   Anaeromyxobacter dehalogenans (strain 2CP-C).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Anaeromyxobacteraceae; Anaeromyxobacter.
OX   NCBI_TaxID=290397;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2CP-C;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C.,
RA   Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S.,
RA   Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the ABC transporter complex PhnCDE involved in
CC       phosphonates import. Responsible for energy coupling to the
CC       transport system. {ECO:0000255|HAMAP-Rule:MF_01713}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + phosphonate(out) = ADP + H(+) + phosphate +
CC         phosphonate(in); Xref=Rhea:RHEA:18065, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16215, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.3.2.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01713};
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins
CC       (PhnC), two transmembrane proteins (PhnE) and a solute-binding
CC       protein (PhnD). {ECO:0000255|HAMAP-Rule:MF_01713}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01713}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01713}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily.
CC       Phosphonates importer (TC 3.A.1.9.1) family. {ECO:0000255|HAMAP-
CC       Rule:MF_01713}.
CC   -!- CAUTION: The fusion between the ATP-binding domain and LysR
CC       substrate binding domain is unusual. It could be due to a
CC       sequencing error. {ECO:0000305}.
DR   EMBL; CP000251; ABC80231.1; -; Genomic_DNA.
DR   RefSeq; WP_011419514.1; NC_007760.1.
DR   SMR; Q2IN45; -.
DR   STRING; 290397.Adeh_0455; -.
DR   PRIDE; Q2IN45; -.
DR   EnsemblBacteria; ABC80231; ABC80231; Adeh_0455.
DR   KEGG; ade:Adeh_0455; -.
DR   eggNOG; ENOG4105D5T; Bacteria.
DR   eggNOG; COG3638; LUCA.
DR   HOGENOM; HOG000003400; -.
DR   KO; K02041; -.
DR   OMA; STHRIEP; -.
DR   BioCyc; ADEH290397:G1G5W-468-MONOMER; -.
DR   Proteomes; UP000001935; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0015416; F:ATPase-coupled organic phosphonate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like.
DR   InterPro; IPR017871; ABC_transporter_CS.
DR   InterPro; IPR012693; ABC_transpr_PhnC.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR   PROSITE; PS51249; PHNC; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q2IN45.
DR   SWISS-2DPAGE; Q2IN45.
KW   ATP-binding; Cell inner membrane; Cell membrane; Complete proteome;
KW   Membrane; Nucleotide-binding; Phosphonate transport;
KW   Reference proteome; Translocase; Transport.
FT   CHAIN         1    498       Phosphonates import ATP-binding protein
FT                                PhnC.
FT                                /FTId=PRO_0000274705.
FT   DOMAIN       28    269       ABC transporter. {ECO:0000255|HAMAP-
FT                                Rule:MF_01713}.
FT   NP_BIND      60     67       ATP. {ECO:0000255|HAMAP-Rule:MF_01713}.
FT   REGION      270    498       LysR substrate binding domain.
SQ   SEQUENCE   498 AA;  52019 MW;  8350FF341618CE9C CRC64;
     MPQRPEAARA GPVAGPDAAS KPAPGPALTL RGAGRAYGPV RALRPLTLEI RRGERVALLG
     PSGAGKSTLL RLLDTSLAPS EGTVEVLGQP VADTDARRLR ALRARIGTVH QQLLLVPQAT
     AMQNVVAGRL GRTSLARTLA ALVSRREAAR VRAVLDEVGI GDKIFERVDR LSGGEQQRVA
     IARTLYQDPE LILADEPLAS VDPARAADIA ALLARAFAGR TLVVSTHRIE PLLAHVDRVV
     ALREGALAFD KPAAALTLRD LGELYEARRG AADPARAPAA RPPSDPVVAP GGTLRIGASS
     TPGEHLLPSI VRAFARAYPG TRVSLSLSDS AAVTAAVRDG ALDLGFVGAR DDDPALAYED
     VARDEIVLVA APVLELPPEP ITLEVAARLP RVDREPGSGT RAVVEQHLAN MGAALDPAAV
     VLEAGALVAL KAAVVSGMGV AFVSRRAVED DLRGGHVRTV RVEGLSIPRH VFAVLRRSPV
     PSAAARAFLE VARAEVPP
//

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