(data stored in ACNUC7421 zone)

SWISSPROT: NIKR_ANADE

ID   NIKR_ANADE              Reviewed;         139 AA.
AC   Q2IN94;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   08-MAY-2019, entry version 76.
DE   RecName: Full=Putative nickel-responsive regulator {ECO:0000255|HAMAP-Rule:MF_00476};
GN   OrderedLocusNames=Adeh_0497;
OS   Anaeromyxobacter dehalogenans (strain 2CP-C).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Anaeromyxobacteraceae; Anaeromyxobacter.
OX   NCBI_TaxID=290397;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2CP-C;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C.,
RA   Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S.,
RA   Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional regulator. {ECO:0000255|HAMAP-
CC       Rule:MF_00476}.
CC   -!- COFACTOR:
CC       Name=Ni(2+); Xref=ChEBI:CHEBI:49786;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00476};
CC       Note=Binds 1 nickel ion per subunit. {ECO:0000255|HAMAP-
CC       Rule:MF_00476};
CC   -!- SIMILARITY: Belongs to the transcriptional regulatory CopG/NikR
CC       family. {ECO:0000255|HAMAP-Rule:MF_00476}.
DR   EMBL; CP000251; ABC80273.1; -; Genomic_DNA.
DR   RefSeq; WP_011419556.1; NC_007760.1.
DR   SMR; Q2IN94; -.
DR   STRING; 290397.Adeh_0497; -.
DR   EnsemblBacteria; ABC80273; ABC80273; Adeh_0497.
DR   KEGG; ade:Adeh_0497; -.
DR   eggNOG; ENOG4105MRR; Bacteria.
DR   eggNOG; COG0864; LUCA.
DR   HOGENOM; HOG000102781; -.
DR   KO; K07722; -.
DR   OMA; HLDHDNC; -.
DR   BioCyc; ADEH290397:G1G5W-510-MONOMER; -.
DR   Proteomes; UP000001935; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0010045; P:response to nickel cation; IEA:InterPro.
DR   Gene3D; 1.10.1220.10; -; 1.
DR   Gene3D; 3.30.70.1150; -; 1.
DR   HAMAP; MF_00476; NikR; 1.
DR   InterPro; IPR027271; Acetolactate_synth/TF_NikR_C.
DR   InterPro; IPR013321; Arc_rbn_hlx_hlx.
DR   InterPro; IPR002145; CopG.
DR   InterPro; IPR022988; Ni_resp_reg_NikR.
DR   InterPro; IPR010985; Ribbon_hlx_hlx.
DR   InterPro; IPR014864; TF_NikR_Ni-bd_C.
DR   Pfam; PF08753; NikR_C; 1.
DR   Pfam; PF01402; RHH_1; 1.
DR   SUPFAM; SSF47598; SSF47598; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q2IN94.
DR   SWISS-2DPAGE; Q2IN94.
KW   Complete proteome; DNA-binding; Metal-binding; Nickel;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN         1    139       Putative nickel-responsive regulator.
FT                                /FTId=PRO_1000014055.
FT   METAL        79     79       Nickel. {ECO:0000255|HAMAP-
FT                                Rule:MF_00476}.
FT   METAL        90     90       Nickel. {ECO:0000255|HAMAP-
FT                                Rule:MF_00476}.
FT   METAL        92     92       Nickel. {ECO:0000255|HAMAP-
FT                                Rule:MF_00476}.
FT   METAL        98     98       Nickel. {ECO:0000255|HAMAP-
FT                                Rule:MF_00476}.
SQ   SEQUENCE   139 AA;  15348 MW;  0560B9096E8595FB CRC64;
     MLERIGISLE DGLLEQFDKL IAEKGYVNRS EAVRDLIRDA LVQRAFTESS GREERVAVVT
     LVYDHDSSSL AQKLAHIQHE NHRAVVSALH VHMDAHNCLE VLVLRGRGKD VVAMGESLVA
     TKGVKYGKLV PATAGHDLR
//

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