(data stored in ACNUC7421 zone)

SWISSPROT: Q147C7_PARXL

ID   Q147C7_PARXL            Unreviewed;       709 AA.
AC   Q147C7;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   08-MAY-2019, entry version 102.
DE   SubName: Full=Heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase {ECO:0000313|EMBL:ABE28562.1};
DE            EC=3.6.1.- {ECO:0000313|EMBL:ABE28562.1};
GN   ORFNames=Bxe_A4439 {ECO:0000313|EMBL:ABE28562.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE28562.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE28562.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE28562.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU362081}.
CC   -!- SIMILARITY: Belongs to the cation transport ATPase (P-type)
CC       (TC 3.A.3) family. Type IB subfamily.
CC       {ECO:0000256|RuleBase:RU362081}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00280}.
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DR   EMBL; CP000270; ABE28562.1; -; Genomic_DNA.
DR   STRING; 266265.Bxe_A4439; -.
DR   EnsemblBacteria; ABE28562; ABE28562; Bxe_A4439.
DR   KEGG; bxe:Bxe_A4439; -.
DR   eggNOG; ENOG4105C59; Bacteria.
DR   eggNOG; COG2217; LUCA.
DR   HOGENOM; HOG000250399; -.
DR   KO; K01534; -.
DR   OMA; VEMLMLF; -.
DR   Proteomes; UP000001817; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0019829; F:cation-transporting ATPase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030001; P:metal ion transport; IEA:InterPro.
DR   Gene3D; 3.40.1110.10; -; 1.
DR   Gene3D; 3.40.50.1000; -; 1.
DR   InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR   InterPro; IPR018303; ATPase_P-typ_P_site.
DR   InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR   InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR006121; HMA_dom.
DR   InterPro; IPR036163; HMA_dom_sf.
DR   InterPro; IPR027256; P-typ_ATPase_IB.
DR   InterPro; IPR001757; P_typ_ATPase.
DR   Pfam; PF00403; HMA; 1.
DR   PRINTS; PR00941; CDATPASE.
DR   SUPFAM; SSF55008; SSF55008; 1.
DR   SUPFAM; SSF56784; SSF56784; 1.
DR   SUPFAM; SSF81653; SSF81653; 1.
DR   SUPFAM; SSF81665; SSF81665; 1.
DR   TIGRFAMs; TIGR01525; ATPase-IB_hvy; 1.
DR   TIGRFAMs; TIGR01494; ATPase_P-type; 1.
DR   PROSITE; PS00154; ATPASE_E1_E2; 1.
DR   PROSITE; PS50846; HMA_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q147C7.
DR   SWISS-2DPAGE; Q147C7.
KW   ATP-binding {ECO:0000256|RuleBase:RU362081};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001817};
KW   Hydrolase {ECO:0000313|EMBL:ABE28562.1};
KW   Membrane {ECO:0000256|RuleBase:RU362081};
KW   Metal-binding {ECO:0000256|RuleBase:RU362081};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362081};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001817};
KW   Transmembrane {ECO:0000256|RuleBase:RU362081};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU362081}.
FT   TRANSMEM    119    138       Helical. {ECO:0000256|RuleBase:RU362081}.
FT   TRANSMEM    323    343       Helical. {ECO:0000256|RuleBase:RU362081}.
FT   TRANSMEM    355    381       Helical. {ECO:0000256|RuleBase:RU362081}.
FT   TRANSMEM    659    680       Helical. {ECO:0000256|RuleBase:RU362081}.
FT   TRANSMEM    686    707       Helical. {ECO:0000256|RuleBase:RU362081}.
FT   DOMAIN       12     76       HMA. {ECO:0000259|PROSITE:PS50846}.
FT   COILED      493    513       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   709 AA;  74859 MW;  8FE84EC352E89B68 CRC64;
     MPQSETVGSD MRTAIRIMQM DCPTEEALIR KKFSRMPHVR SMDFNLMQRI LTVVHAPEAL
     DSILAALRSL DFTPELANAA PDTAPTAAPH TPPKPWWPLA LAGAAAAGSE AAGWLGAPGW
     LPAALAILAI LSCGLTTYRK GWLAIRNGNL NINALMSIAV TGALILRQWP EAAMVMVLFT
     IAELIEAKSL DRARNAIQGL MQLTPEEASV QQPDGGWRST ELKAIAPGAV VRVKPGERVA
     LDGEIVAGRS TVNQAPITGE SLPVDKAVGD AVFAGTINQT GSFDYRVSAA ASNTTLARII
     HAVEEAQATK APTQRFVDQF ARVYTPIVFA VALAVAIVPP LLFGGSWQAW IYKALVMLVI
     ACPCALVIST PVTIVSGLAA AARKGILIKG GAYLEQGRKL TRLALDKTGT ITHGKPVQTE
     FEILAEVDAG RCRTLAASLA GRSDHPVSMA LAAAAKADGV TSLTVGAFEA LTGRGVRGEI
     DGLSYWLGNH RLVEELGRCS ASLEARLDAL ERQGRTVVML VDGERVLALF AVADTVKESS
     RAAIAELQHL GVKTAMLTGD NPHTAAAIAQ QVGVDEARGN QLPEDKLNAI AQWSKEHATV
     GMVGDGINDA PALARADIGF AMGAMGTDTA IETADVALMD DDLRKIPSFI RLSKATHSVL
     VQNITLALGI KSVFLVLTVI GLGTMWMAVF ADVGASLLVV ANGLRLLRK
//

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