(data stored in ACNUC7421 zone)

SWISSPROT: Q147B2_PARXL

ID   Q147B2_PARXL            Unreviewed;       363 AA.
AC   Q147B2;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   08-MAY-2019, entry version 82.
DE   SubName: Full=Putative 2-hydroxyacid dehydrogenase {ECO:0000313|EMBL:ABE28577.1};
GN   ORFNames=Bxe_A4423 {ECO:0000313|EMBL:ABE28577.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE28577.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE28577.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE28577.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR   EMBL; CP000270; ABE28577.1; -; Genomic_DNA.
DR   STRING; 266265.Bxe_A4423; -.
DR   EnsemblBacteria; ABE28577; ABE28577; Bxe_A4423.
DR   KEGG; bxe:Bxe_A4423; -.
DR   eggNOG; ENOG4105DPQ; Bacteria.
DR   eggNOG; COG0111; LUCA.
DR   HOGENOM; HOG000136700; -.
DR   KO; K00058; -.
DR   OMA; DHEVKVF; -.
DR   Proteomes; UP000001817; Chromosome 1.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q147B2.
DR   SWISS-2DPAGE; Q147B2.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001817};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003719};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001817}.
FT   DOMAIN       45    351       2-Hacid_dh. {ECO:0000259|Pfam:PF00389}.
FT   DOMAIN      137    322       2-Hacid_dh_C. {ECO:0000259|Pfam:PF02826}.
SQ   SEQUENCE   363 AA;  40540 MW;  138A555A55A5BE28 CRC64;
     MTWVTWWDSQ HNTPFRTTEV RRKTHTMKIA ILDDYQDAVR KLDCFQLLAD HEVKVFNNTV
     RGLGQLASRL AEVDALVLIR ERTRISSQLL DKLPRLRMIS QTGKVSSHID LAACTERGIA
     VLEGTGSPFA PAELTWALIM AAQRRIPQYV ANLKQGAWQQ SGLKTSALPP NFGLGQVLRG
     QTLGIWGYGK IGRLVAGYGK AFGMNVLIWG REHSREAARA DGYGVAESRE ALFEQSDVLS
     LHLRLHDDTR GIVKQEDLMR MKPTALLVNT SRAELLDENA LVNALSHNRP GMVAIDVYES
     EPILQGYSLL RMENVICTPH IGYVERESYE QYFTAAFNNI LAFDAGDPAS VANPEALQGG
     RRR
//

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