(data stored in ACNUC7421 zone)

SWISSPROT: Q146W5_PARXL

ID   Q146W5_PARXL            Unreviewed;       400 AA.
AC   Q146W5;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   08-MAY-2019, entry version 87.
DE   SubName: Full=23S rRNA m(5)C-1962 methyltransferase / SAM-dependent methyltransferase {ECO:0000313|EMBL:ABE28624.1};
DE            EC=2.1.1.- {ECO:0000313|EMBL:ABE28624.1};
GN   ORFNames=Bxe_A4376 {ECO:0000313|EMBL:ABE28624.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE28624.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE28624.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE28624.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00351055}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. RlmI
CC       family. {ECO:0000256|SAAS:SAAS00545036}.
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DR   EMBL; CP000270; ABE28624.1; -; Genomic_DNA.
DR   RefSeq; WP_011486476.1; NZ_CP008760.1.
DR   STRING; 266265.Bxe_A4376; -.
DR   EnsemblBacteria; ABE28624; ABE28624; Bxe_A4376.
DR   GeneID; 4005529; -.
DR   KEGG; bxb:DR64_2053; -.
DR   KEGG; bxe:Bxe_A4376; -.
DR   PATRIC; fig|266265.5.peg.89; -.
DR   eggNOG; ENOG4105DR4; Bacteria.
DR   eggNOG; COG1092; LUCA.
DR   HOGENOM; HOG000266009; -.
DR   KO; K06969; -.
DR   OMA; VMDVFDY; -.
DR   OrthoDB; 468283at2; -.
DR   BioCyc; BXEN266265:BXE_RS00425-MONOMER; -.
DR   Proteomes; UP000001817; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.130.10; -; 1.
DR   InterPro; IPR002478; PUA.
DR   InterPro; IPR015947; PUA-like_sf.
DR   InterPro; IPR036974; PUA_sf.
DR   InterPro; IPR041532; RlmI_PUA-like.
DR   InterPro; IPR019614; SAM-dep_methyl-trfase.
DR   InterPro; IPR029063; SAM-dependent_MTases.
DR   Pfam; PF10672; Methyltrans_SAM; 1.
DR   Pfam; PF17785; PUA_3; 1.
DR   SMART; SM00359; PUA; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   SUPFAM; SSF88697; SSF88697; 1.
DR   PROSITE; PS50890; PUA; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q146W5.
DR   SWISS-2DPAGE; Q146W5.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001817};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00428966};
KW   Methyltransferase {ECO:0000256|SAAS:SAAS00429068,
KW   ECO:0000313|EMBL:ABE28624.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001817};
KW   RNA-binding {ECO:0000256|SAAS:SAAS00469861};
KW   rRNA processing {ECO:0000256|SAAS:SAAS00429013};
KW   S-adenosyl-L-methionine {ECO:0000256|SAAS:SAAS00429032};
KW   Transferase {ECO:0000256|SAAS:SAAS00429003,
KW   ECO:0000313|EMBL:ABE28624.1}.
FT   DOMAIN        1     78       PUA. {ECO:0000259|PROSITE:PS50890}.
SQ   SEQUENCE   400 AA;  44010 MW;  68EA48F6A6B420B1 CRC64;
     MNTVTLKPSK EKSLLRRHPW VYANAIDRID GNPAPGATVL VRAHDGRFLA RAAYSPHSQI
     RARVWSFDET EPIDHAFFKR RVQRALAHRQ TMVHDTGAVR LIFGEADGLP GLIVDHYVAE
     DEGQRSQLVC QFMAAGVEAW KEAIVAALTG ATGCPNVYER SDVSIRQKEG LEQITGVLAG
     EPPSEALIVS ENDVRYHVDV RNGHKTGFYV DQRDNRPLVQ QLAQDRDMLN CFCYTGGFSL
     AALKGGAKRV VSIDSSGDAL AIAQQNVAAN GFDAERATWL DADAFKTLRR LYDDGERFDL
     VVLDPPKFAP SREHVDRASR AYKDINLTGL KLLRPGGLLF TYSCSGAIDS ELFQKIISGA
     AADARVDARI LKRLGAGMDH PLLTAFPEGE YLKGLLLQIA
//

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