(data stored in ACNUC7421 zone)

SWISSPROT: Q146W4_PARXL

ID   Q146W4_PARXL            Unreviewed;       307 AA.
AC   Q146W4;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   08-MAY-2019, entry version 97.
DE   RecName: Full=Tyrosine recombinase XerC {ECO:0000256|HAMAP-Rule:MF_01808, ECO:0000256|SAAS:SAAS00055375};
GN   Name=xerC {ECO:0000256|HAMAP-Rule:MF_01808};
GN   ORFNames=Bxe_A4375 {ECO:0000313|EMBL:ABE28625.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE28625.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE28625.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE28625.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- FUNCTION: Site-specific tyrosine recombinase, which acts by
CC       catalyzing the cutting and rejoining of the recombining DNA
CC       molecules. The XerC-XerD complex is essential to convert dimers of
CC       the bacterial chromosome into monomers to permit their segregation
CC       at cell division. It also contributes to the segregational
CC       stability of plasmids. {ECO:0000256|HAMAP-Rule:MF_01808}.
CC   -!- SUBUNIT: Forms a cyclic heterotetrameric complex composed of two
CC       molecules of XerC and two molecules of XerD. {ECO:0000256|HAMAP-
CC       Rule:MF_01808, ECO:0000256|SAAS:SAAS00608017}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01808,
CC       ECO:0000256|SAAS:SAAS00019473}.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. XerC
CC       subfamily. {ECO:0000256|HAMAP-Rule:MF_01808,
CC       ECO:0000256|SAAS:SAAS00608022}.
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DR   EMBL; CP000270; ABE28625.1; -; Genomic_DNA.
DR   RefSeq; WP_011486477.1; NZ_CP008760.1.
DR   STRING; 266265.Bxe_A4375; -.
DR   EnsemblBacteria; ABE28625; ABE28625; Bxe_A4375.
DR   GeneID; 4005530; -.
DR   KEGG; bxb:DR64_2052; -.
DR   KEGG; bxe:Bxe_A4375; -.
DR   PATRIC; fig|266265.5.peg.90; -.
DR   eggNOG; ENOG4108IYS; Bacteria.
DR   eggNOG; COG4973; LUCA.
DR   HOGENOM; HOG000045294; -.
DR   KO; K03733; -.
DR   OMA; FASHMLE; -.
DR   OrthoDB; 745068at2; -.
DR   BioCyc; BXEN266265:BXE_RS00430-MONOMER; -.
DR   Proteomes; UP000001817; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; -; 1.
DR   HAMAP; MF_01808; Recomb_XerC_XerD; 1.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   InterPro; IPR004107; Integrase_SAM-like_N.
DR   InterPro; IPR011931; Recomb_XerC.
DR   InterPro; IPR023009; Tyrosine_recombinase_XerC/XerD.
DR   Pfam; PF02899; Phage_int_SAM_1; 1.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   TIGRFAMs; TIGR02224; recomb_XerC; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q146W4.
DR   SWISS-2DPAGE; Q146W4.
KW   Cell cycle {ECO:0000256|HAMAP-Rule:MF_01808,
KW   ECO:0000256|SAAS:SAAS00608023};
KW   Cell division {ECO:0000256|HAMAP-Rule:MF_01808,
KW   ECO:0000256|SAAS:SAAS00608024};
KW   Chromosome partition {ECO:0000256|HAMAP-Rule:MF_01808,
KW   ECO:0000256|SAAS:SAAS00608018};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001817};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01808,
KW   ECO:0000256|SAAS:SAAS00094312};
KW   DNA integration {ECO:0000256|HAMAP-Rule:MF_01808,
KW   ECO:0000256|SAAS:SAAS00298355};
KW   DNA recombination {ECO:0000256|HAMAP-Rule:MF_01808,
KW   ECO:0000256|SAAS:SAAS00019433};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_01808,
KW   ECO:0000256|SAAS:SAAS00424103};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001817}.
FT   DOMAIN        7     84       Integrase_SAM-like_N. {ECO:0000259|Pfam:
FT                                PF02899}.
FT   DOMAIN      110    289       Phage_integrase. {ECO:0000259|Pfam:
FT                                PF00589}.
FT   ACT_SITE    145    145       {ECO:0000256|HAMAP-Rule:MF_01808}.
FT   ACT_SITE    180    180       {ECO:0000256|HAMAP-Rule:MF_01808}.
FT   ACT_SITE    249    249       {ECO:0000256|HAMAP-Rule:MF_01808}.
FT   ACT_SITE    252    252       {ECO:0000256|HAMAP-Rule:MF_01808}.
FT   ACT_SITE    275    275       {ECO:0000256|HAMAP-Rule:MF_01808}.
FT   ACT_SITE    284    284       O-(3'-phospho-DNA)-tyrosine intermediate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01808}.
SQ   SEQUENCE   307 AA;  33651 MW;  C3F48D63DFF5117E CRC64;
     MTAADPIAAY LSNLEHERRL SAHTLRGYTH ELEELKLLAK GRPLESLSAV DIRGAVSRAH
     AGGLTARSIS HRLSAWRAFY RWLAGRVDLP ANPVATVRAP KQPKTLPKAL SVDDATRLME
     SPPAASPEGL RDHAMLELFY SSGLRLAELV GLDARFADAD GYRSAGWIKL DSAEVEVLGK
     GNRRRVVPVG SKALEALAAW LAVRDQMVKH DPHPLFLSAR GNRLSPNVVR ERVKRAALVA
     GIPANVHPHV LRHSFATHVL QSSGDLRAVQ ELLGHASITA TQVYTALDFQ HLAHVYDQAH
     PRAKKRD
//

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