(data stored in ACNUC7421 zone)

SWISSPROT: Q146V1_PARXL

ID   Q146V1_PARXL            Unreviewed;      1060 AA.
AC   Q146V1;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   08-MAY-2019, entry version 64.
DE   SubName: Full=Cation/multidrug efflux pump, AcrB/AcrD/AcrF family, RND superfamily {ECO:0000313|EMBL:ABE28638.1};
GN   ORFNames=Bxe_A4362 {ECO:0000313|EMBL:ABE28638.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE28638.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE28638.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE28638.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division
CC       (RND) (TC 2.A.6) family. {ECO:0000256|SAAS:SAAS01080844}.
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DR   EMBL; CP000270; ABE28638.1; -; Genomic_DNA.
DR   RefSeq; WP_011486489.1; NZ_CP008760.1.
DR   STRING; 266265.Bxe_A4362; -.
DR   EnsemblBacteria; ABE28638; ABE28638; Bxe_A4362.
DR   GeneID; 4002719; -.
DR   KEGG; bxb:DR64_2038; -.
DR   KEGG; bxe:Bxe_A4362; -.
DR   PATRIC; fig|266265.5.peg.106; -.
DR   eggNOG; ENOG4105BZS; Bacteria.
DR   eggNOG; COG0841; LUCA.
DR   HOGENOM; HOG000158132; -.
DR   OMA; YNVITEA; -.
DR   OrthoDB; 145346at2; -.
DR   BioCyc; BXEN266265:BXE_RS00500-MONOMER; -.
DR   Proteomes; UP000001817; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
PE   3: Inferred from homology;
DR   PRODOM; Q146V1.
DR   SWISS-2DPAGE; Q146V1.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001817};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001817};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    334    353       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    360    380       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    386    410       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    431    452       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    458    477       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    541    560       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    883    905       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    912    930       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    936    959       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    987   1006       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1018   1042       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   1060 AA;  115129 MW;  1FA654D1640599C4 CRC64;
     MWIVRLALRR PYTFVVLALL LLIVGPLTIL RTPTDIFPNI DIPVLSVIWS YNGLPADEME
     KRIVLNYERG LSTAVNDIEH TESTSLNGIA VVKIFFQPHA NIDEALAQVT ALSQTQLRSL
     PPGITPPNIL RYNASTVPIL RLALSSASLT EQELYDFGNN FLKTQLATVP GASAPLPYGG
     KQRQIMVDID SRKLQERNLS PMDVVNAVTA QNLILPSGTA KIGSTEYSVE MNGSPDSLAG
     LNNIPIQSTA NGTVYIRDVA HVRDGFQPQT NIVRVNGQRA ALLTINKSGN TSTLEIVDRI
     KTMMPTLRNL VPASLNIDPV ADQSLFVRAS VQGVLREALI AACLTGLMIL LFLGNWRATL
     IIAVSIPLSM ITSIIALSLL GETINIMTLG GLALAVGILV DDATVAIENI SHQLEQGKTL
     EQAILDGAHQ IAIPTLVSTL SICIVFVPMF LLTGVAHYLF IPLAEAVVFA MLASYFFSRT
     LVPTLAKYLL RYHHKAADLH HAPTQTRNPF MRAHYAFEGG FERLRERYRV FLEARVARPG
     LFVTLFLVCC GASMLLMPFL GRDFFPAVDA GTIALHLRAK TGMRVEETAV VTDRVDTRIR
     QLIPAGELHS IIDNIGLPVS GINLSYSNTG TIGTSDADVL ITLNPDHHPS ANYVRTLRRT
     LTDEFPGVQF AFLPADIVSQ TLNFGMPSPI DIQIVGREVA ANRVFAAKLL NRLRTVPGLA
     DARIQQPADL PRIFIDVDRT RAQQAGFSQR DIASNLLITL SGSQQTTPTF WLNPRNGVSY
     NVITEAPQYT IDSLQSLANI PLNANGRSNI LGSLATMKRE AGNATLTHYN AQTTIDIFGT
     ADGRDLGGVS DDIRKIIDDV KADLPRSSTI EVRGQVQTMN DSFSGLFAGL VFAILLVYLL
     IVVNFQSWLD PFIIVTALPG ALAGIVWMLF LTHTTLSIPA LTGAIMCIGI ATANSILVIS
     FAREQLLEHG DAARAAIEAG FTRFRPVLMT ALAMVIGMVP MAIGLGEGGE QNAPLGRAVI
     GGLTIGTLAT LIFVPVVFSM IYRRLAARRL RAAEHVVQKP
//

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