(data stored in ACNUC7421 zone)

SWISSPROT: DCTA_PARXL

ID   DCTA_PARXL              Reviewed;         426 AA.
AC   Q146D6;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   08-MAY-2019, entry version 79.
DE   RecName: Full=C4-dicarboxylate transport protein {ECO:0000255|HAMAP-Rule:MF_01300};
GN   Name=dctA {ECO:0000255|HAMAP-Rule:MF_01300};
GN   OrderedLocusNames=Bxeno_A0265; ORFNames=Bxe_A4197;
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400;
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- FUNCTION: Responsible for the transport of dicarboxylates such as
CC       succinate, fumarate, and malate from the periplasm across the
CC       membrane. {ECO:0000255|HAMAP-Rule:MF_01300}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01300}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01300}.
CC   -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation
CC       symporter (DAACS) (TC 2.A.23) family. {ECO:0000255|HAMAP-
CC       Rule:MF_01300}.
DR   EMBL; CP000270; ABE28803.1; -; Genomic_DNA.
DR   RefSeq; WP_011486643.1; NZ_CP008760.1.
DR   STRING; 266265.Bxe_A4197; -.
DR   PRIDE; Q146D6; -.
DR   EnsemblBacteria; ABE28803; ABE28803; Bxe_A4197.
DR   GeneID; 4004741; -.
DR   KEGG; bxb:DR64_1875; -.
DR   KEGG; bxe:Bxe_A4197; -.
DR   PATRIC; fig|266265.5.peg.279; -.
DR   eggNOG; ENOG4105CK2; Bacteria.
DR   eggNOG; COG1301; LUCA.
DR   HOGENOM; HOG000208775; -.
DR   KO; K11103; -.
DR   OMA; YLYIAVI; -.
DR   OrthoDB; 781228at2; -.
DR   BioCyc; BXEN266265:BXE_RS01310-MONOMER; -.
DR   Proteomes; UP000001817; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006835; P:dicarboxylic acid transport; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.3860.10; -; 1.
DR   HAMAP; MF_01300; C4_dicarb_transport; 1.
DR   InterPro; IPR023954; C4_dicarb_transport.
DR   InterPro; IPR001991; Na-dicarboxylate_symporter.
DR   InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR   InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR   Pfam; PF00375; SDF; 1.
DR   SUPFAM; SSF118215; SSF118215; 1.
DR   PROSITE; PS00713; NA_DICARBOXYL_SYMP_1; 1.
DR   PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q146D6.
DR   SWISS-2DPAGE; Q146D6.
KW   Cell inner membrane; Cell membrane; Complete proteome; Membrane;
KW   Reference proteome; Symport; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN         1    426       C4-dicarboxylate transport protein.
FT                                /FTId=PRO_1000067441.
FT   TRANSMEM      8     28       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01300}.
FT   TRANSMEM     44     64       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01300}.
FT   TRANSMEM     78     98       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01300}.
FT   TRANSMEM    148    168       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01300}.
FT   TRANSMEM    173    193       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01300}.
FT   TRANSMEM    222    242       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01300}.
FT   TRANSMEM    297    317       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01300}.
FT   TRANSMEM    355    375       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01300}.
SQ   SEQUENCE   426 AA;  44909 MW;  617E4502A5644793 CRC64;
     MKKPIHKVLY VQVIVAIIIG IGLGHFYPDL AVDMKPLGDG FIKLIKMVIG PIIFCTVVTG
     IAGMEDMKKV GRVGGKALLY FEIVSTFALV LGLIATHVLK PGVGFNIDPA TLDGKAVASY
     AAKAHGQTTV DFLMHIIPDT LVSAFAQGEI LQILLIALLF GAVLATAGEK GKVVTGFIDG
     LSHVLFGIVR IITKLAPIGA FGAMAFTIGK YGIGSLLPML KLIGTFYLTS VVFVVVVLGI
     IARAVGFNIL RFVAYIKEEM LIVLGTSSSE AALPQLMLKL ERLGCSRSVV GLVVPTGYSF
     NLDGTNIYMT MAVLFIAQAT NTDLTWTQQL TLLAVTMLTS KGASGVTGAG FITLAATLAV
     VPTIPLSGMV LILGIDRFMS ECRALTNIVG NGVATVVVSA WEKELDRSKL NAALRGDVAI
     KEPAGV
//

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