(data stored in ACNUC7421 zone)

SWISSPROT: Q145V1_PARXL

ID   Q145V1_PARXL            Unreviewed;       289 AA.
AC   Q145V1;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   08-MAY-2019, entry version 79.
DE   RecName: Full=Formyltetrahydrofolate deformylase {ECO:0000256|HAMAP-Rule:MF_01927};
DE            EC=3.5.1.10 {ECO:0000256|HAMAP-Rule:MF_01927};
DE   AltName: Full=Formyl-FH(4) hydrolase {ECO:0000256|HAMAP-Rule:MF_01927};
GN   Name=purU {ECO:0000256|HAMAP-Rule:MF_01927};
GN   ORFNames=Bxe_A4112 {ECO:0000313|EMBL:ABE28888.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE28888.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE28888.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE28888.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- FUNCTION: Catalyzes the hydrolysis of 10-formyltetrahydrofolate
CC       (formyl-FH4) to formate and tetrahydrofolate (FH4).
CC       {ECO:0000256|HAMAP-Rule:MF_01927}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6S)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-
CC         tetrahydrofolate + formate + H(+); Xref=Rhea:RHEA:19833,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15740,
CC         ChEBI:CHEBI:57453, ChEBI:CHEBI:57454; EC=3.5.1.10;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01927};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       formate from 10-formyl-5,6,7,8-tetrahydrofolate: step 1/1.
CC       {ECO:0000256|HAMAP-Rule:MF_01927}.
CC   -!- SIMILARITY: Belongs to the PurU family. {ECO:0000256|HAMAP-
CC       Rule:MF_01927}.
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DR   EMBL; CP000270; ABE28888.1; -; Genomic_DNA.
DR   RefSeq; WP_011486717.1; NZ_CP008760.1.
DR   STRING; 266265.Bxe_A4112; -.
DR   EnsemblBacteria; ABE28888; ABE28888; Bxe_A4112.
DR   GeneID; 4005040; -.
DR   KEGG; bxb:DR64_1788; -.
DR   KEGG; bxe:Bxe_A4112; -.
DR   PATRIC; fig|266265.5.peg.370; -.
DR   eggNOG; ENOG4105CIY; Bacteria.
DR   eggNOG; COG0788; LUCA.
DR   HOGENOM; HOG000033576; -.
DR   KO; K01433; -.
DR   OMA; KWHSEHR; -.
DR   OrthoDB; 979667at2; -.
DR   BioCyc; BXEN266265:BXE_RS01755-MONOMER; -.
DR   UniPathway; UPA00074; UER00170.
DR   Proteomes; UP000001817; Chromosome 1.
DR   GO; GO:0008864; F:formyltetrahydrofolate deformylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016742; F:hydroxymethyl-, formyl- and related transferase activity; IEA:InterPro.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd08648; FMT_core_Formyl-FH4-Hydrolase_; 1.
DR   HAMAP; MF_01927; PurU; 1.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR041729; Formyl-FH4-Hydrolase_C.
DR   InterPro; IPR002376; Formyl_transf_N.
DR   InterPro; IPR036477; Formyl_transf_N_sf.
DR   InterPro; IPR004810; PurU.
DR   PANTHER; PTHR42706; PTHR42706; 1.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00551; Formyl_trans_N; 1.
DR   PRINTS; PR01575; FFH4HYDRLASE.
DR   SUPFAM; SSF53328; SSF53328; 1.
DR   TIGRFAMs; TIGR00655; PurU; 1.
DR   PROSITE; PS51671; ACT; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q145V1.
DR   SWISS-2DPAGE; Q145V1.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001817};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_01927,
KW   ECO:0000313|EMBL:ABE28888.1};
KW   One-carbon metabolism {ECO:0000256|HAMAP-Rule:MF_01927};
KW   Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_01927};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001817}.
FT   DOMAIN        8     95       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   ACT_SITE    233    233       {ECO:0000256|HAMAP-Rule:MF_01927}.
SQ   SEQUENCE   289 AA;  32254 MW;  B71B29C4AC87347E CRC64;
     MSTDHSFILK LSCADRPGIV HAVSGFLFER GSNILDSAQF GDSRTGEFFM RVHFQQVGGD
     PGLEALRASF ATLAEQFGMR WELHDASVKP RVVIMVSKIG HCLNDLLFRY RTGQLGIEIA
     AIISNHKEFY QLAASYDIPF HHFPLMGATP EAKAAQEARV LEVIDEHQAD LVVLARYMQI
     LSPKLCEALA GRAINIHHSF LPSFKGAKPY YQAFDRGVKL IGATAHYVTT DLDEGPIIEQ
     EVERVDHSMT PEQLTAIGRD VECVTLARAV KWHVEHRVVL NGSKTVVFR
//

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