(data stored in ACNUC7421 zone)

SWISSPROT: PUR5_PARXL

ID   PUR5_PARXL              Reviewed;         355 AA.
AC   Q145C6;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   08-MAY-2019, entry version 83.
DE   RecName: Full=Phosphoribosylformylglycinamidine cyclo-ligase {ECO:0000255|HAMAP-Rule:MF_00741};
DE            EC=6.3.3.1 {ECO:0000255|HAMAP-Rule:MF_00741};
DE   AltName: Full=AIR synthase {ECO:0000255|HAMAP-Rule:MF_00741};
DE   AltName: Full=AIRS {ECO:0000255|HAMAP-Rule:MF_00741};
DE   AltName: Full=Phosphoribosyl-aminoimidazole synthetase {ECO:0000255|HAMAP-Rule:MF_00741};
GN   Name=purM {ECO:0000255|HAMAP-Rule:MF_00741};
GN   OrderedLocusNames=Bxeno_A0525; ORFNames=Bxe_A3936;
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400;
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP
CC         = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) +
CC         phosphate; Xref=Rhea:RHEA:23032, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58478,
CC         ChEBI:CHEBI:137981, ChEBI:CHEBI:456216; EC=6.3.3.1;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00741};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-
CC       phospho-D-ribosyl)glycinamide: step 2/2. {ECO:0000255|HAMAP-
CC       Rule:MF_00741}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00741}.
CC   -!- SIMILARITY: Belongs to the AIR synthase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00741}.
DR   EMBL; CP000270; ABE29063.1; -; Genomic_DNA.
DR   RefSeq; WP_011486883.1; NZ_CP008760.1.
DR   SMR; Q145C6; -.
DR   STRING; 266265.Bxe_A3936; -.
DR   EnsemblBacteria; ABE29063; ABE29063; Bxe_A3936.
DR   GeneID; 4001927; -.
DR   KEGG; bxb:DR64_1613; -.
DR   KEGG; bxe:Bxe_A3936; -.
DR   PATRIC; fig|266265.5.peg.547; -.
DR   eggNOG; ENOG4105CXB; Bacteria.
DR   eggNOG; COG0150; LUCA.
DR   HOGENOM; HOG000229090; -.
DR   KO; K01933; -.
DR   OMA; GCEQAGC; -.
DR   OrthoDB; 923547at2; -.
DR   BioCyc; BXEN266265:BXE_RS02590-MONOMER; -.
DR   UniPathway; UPA00074; UER00129.
DR   Proteomes; UP000001817; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004641; F:phosphoribosylformylglycinamidine cyclo-ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd02196; PurM; 1.
DR   Gene3D; 3.30.1330.10; -; 1.
DR   Gene3D; 3.90.650.10; -; 1.
DR   HAMAP; MF_00741; AIRS; 1.
DR   InterPro; IPR010918; PurM-like_C_dom.
DR   InterPro; IPR036676; PurM-like_C_sf.
DR   InterPro; IPR016188; PurM-like_N.
DR   InterPro; IPR036921; PurM-like_N_sf.
DR   InterPro; IPR004733; PurM_cligase.
DR   PANTHER; PTHR10520; PTHR10520; 1.
DR   Pfam; PF00586; AIRS; 1.
DR   Pfam; PF02769; AIRS_C; 1.
DR   SUPFAM; SSF55326; SSF55326; 1.
DR   SUPFAM; SSF56042; SSF56042; 1.
DR   TIGRFAMs; TIGR00878; purM; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q145C6.
DR   SWISS-2DPAGE; Q145C6.
KW   ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding;
KW   Purine biosynthesis; Reference proteome.
FT   CHAIN         1    355       Phosphoribosylformylglycinamidine cyclo-
FT                                ligase.
FT                                /FTId=PRO_0000258344.
SQ   SEQUENCE   355 AA;  37014 MW;  C0D7007B0AB63F8F CRC64;
     MNQPKSAPNS TDSAQGLSYR DAGVDIDAGD ALVDAIKPFA RKTMRDGVLG GIGGFGALFE
     VPKKYKEPVL VSGTDGVGTK LRLAFQLNKH DTVGQDLVAM SVNDILVQGA EPLFFLDYFA
     CGKLDVGTAA TVVKGIAYGC ELSGCALIGG ETAEMPGMYP DGEYDLAGFA VGAVEKSKII
     DGSTIAPGDV VLGLASSGIH SNGFSLVRKI IERAQPDLNA DFDGRSLADA LMAPTHIYVK
     PLLALMQQIA VKGMAHITGG GLVENIPRVL REGLTAELDH RGWPLPPLFS WLQKHGGVAD
     AEMHRVFNCG IGMAVVVSAA DADAAIGLLS AAGEQVWKIG VIRESAAGEA QTVVI
//

If you have problems or comments...

PBIL Back to PBIL home page