(data stored in ACNUC7421 zone)

SWISSPROT: NRDR_PARXL

ID   NRDR_PARXL              Reviewed;         160 AA.
AC   Q145A5;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   11-DEC-2019, entry version 77.
DE   RecName: Full=Transcriptional repressor NrdR {ECO:0000255|HAMAP-Rule:MF_00440};
GN   Name=nrdR {ECO:0000255|HAMAP-Rule:MF_00440}; OrderedLocusNames=Bxeno_A0546;
GN   ORFNames=Bxe_A3913;
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400;
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M., Lao V.,
RA   Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A., Marx C.J.,
RA   Parnell J.J., Ramette A., Richardson P., Seeger M., Smith D., Spilker T.,
RA   Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B., Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome
RT   shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- FUNCTION: Negatively regulates transcription of bacterial
CC       ribonucleotide reductase nrd genes and operons by binding to NrdR-
CC       boxes. {ECO:0000255|HAMAP-Rule:MF_00440}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00440};
CC       Note=Binds 1 zinc ion. {ECO:0000255|HAMAP-Rule:MF_00440};
CC   -!- SIMILARITY: Belongs to the NrdR family. {ECO:0000255|HAMAP-
CC       Rule:MF_00440}.
DR   EMBL; CP000270; ABE29084.1; -; Genomic_DNA.
DR   RefSeq; WP_007179115.1; NZ_CP008760.1.
DR   STRING; 266265.Bxe_A3913; -.
DR   PRIDE; Q145A5; -.
DR   EnsemblBacteria; ABE29084; ABE29084; Bxe_A3913.
DR   GeneID; 4001913; -.
DR   KEGG; bxb:DR64_1589; -.
DR   KEGG; bxe:Bxe_A3913; -.
DR   eggNOG; ENOG4108Z11; Bacteria.
DR   eggNOG; COG1327; LUCA.
DR   HOGENOM; HOG000097653; -.
DR   KO; K07738; -.
DR   OMA; RFTTYET; -.
DR   OrthoDB; 1551627at2; -.
DR   BioCyc; BXEN266265:BXE_RS02705-MONOMER; -.
DR   Proteomes; UP000001817; Chromosome 1.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00440; NrdR; 1.
DR   InterPro; IPR005144; ATP-cone_dom.
DR   InterPro; IPR003796; RNR_NrdR-like.
DR   PANTHER; PTHR30455; PTHR30455; 1.
DR   Pfam; PF03477; ATP-cone; 1.
DR   TIGRFAMs; TIGR00244; TIGR00244; 1.
DR   PROSITE; PS51161; ATP_CONE; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q145A5.
DR   SWISS-2DPAGE; Q145A5.
KW   ATP-binding; DNA-binding; Metal-binding; Nucleotide-binding;
KW   Reference proteome; Repressor; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..160
FT                   /note="Transcriptional repressor NrdR"
FT                   /id="PRO_0000264165"
FT   DOMAIN          49..139
FT                   /note="ATP-cone"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
FT   ZN_FING         3..34
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
SQ   SEQUENCE   160 AA;  18506 MW;  6E4BE8FC1531BB1E CRC64;
     MHCPFCRHAD TQVVDSRVSE DGATIRRRRR CPACDKRFTT YERVELALPS VVKKDGSRTE
     FDRRKIVASM QLALRKRPVA ADAIEAAVAR IEYQLLGSGE REVRSERLGE LVMNELRALD
     TIAYVRFASV YRRFEDVSEF EDVIEEFRRA SSPPKPSRKR
//

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