(data stored in ACNUC7421 zone)

SWISSPROT: PYRB_PARXL

ID   PYRB_PARXL              Reviewed;         341 AA.
AC   Q144P9;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   08-MAY-2019, entry version 79.
DE   RecName: Full=Aspartate carbamoyltransferase {ECO:0000255|HAMAP-Rule:MF_00001};
DE            EC=2.1.3.2 {ECO:0000255|HAMAP-Rule:MF_00001};
DE   AltName: Full=Aspartate transcarbamylase {ECO:0000255|HAMAP-Rule:MF_00001};
DE            Short=ATCase {ECO:0000255|HAMAP-Rule:MF_00001};
GN   Name=pyrB {ECO:0000255|HAMAP-Rule:MF_00001};
GN   OrderedLocusNames=Bxeno_A0652; ORFNames=Bxe_A3808;
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400;
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-
CC         aspartate + phosphate; Xref=Rhea:RHEA:20013, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29991, ChEBI:CHEBI:32814, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:58228; EC=2.1.3.2; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00001};
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC       pathway; (S)-dihydroorotate from bicarbonate: step 2/3.
CC       {ECO:0000255|HAMAP-Rule:MF_00001}.
CC   -!- SIMILARITY: Belongs to the ATCase/OTCase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00001}.
DR   EMBL; CP000270; ABE29190.1; -; Genomic_DNA.
DR   RefSeq; WP_007178987.1; NZ_CP008760.1.
DR   SMR; Q144P9; -.
DR   STRING; 266265.Bxe_A3808; -.
DR   EnsemblBacteria; ABE29190; ABE29190; Bxe_A3808.
DR   GeneID; 4002578; -.
DR   KEGG; bxb:DR64_1485; -.
DR   KEGG; bxe:Bxe_A3808; -.
DR   eggNOG; ENOG4105CXT; Bacteria.
DR   eggNOG; COG0540; LUCA.
DR   HOGENOM; HOG000022685; -.
DR   KO; K00609; -.
DR   OMA; WCDVANM; -.
DR   OrthoDB; 1844275at2; -.
DR   BioCyc; BXEN266265:BXE_RS03220-MONOMER; -.
DR   UniPathway; UPA00070; UER00116.
DR   Proteomes; UP000001817; Chromosome 1.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR   GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1370; -; 2.
DR   HAMAP; MF_00001; Asp_carb_tr; 1.
DR   InterPro; IPR006132; Asp/Orn_carbamoyltranf_P-bd.
DR   InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR   InterPro; IPR036901; Asp/Orn_carbamoylTrfase_sf.
DR   InterPro; IPR002082; Asp_carbamoyltransf.
DR   InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn-bd.
DR   PANTHER; PTHR11405:SF16; PTHR11405:SF16; 1.
DR   Pfam; PF00185; OTCace; 1.
DR   Pfam; PF02729; OTCace_N; 1.
DR   PRINTS; PR00100; AOTCASE.
DR   SUPFAM; SSF53671; SSF53671; 1.
DR   TIGRFAMs; TIGR00670; asp_carb_tr; 1.
DR   PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q144P9.
DR   SWISS-2DPAGE; Q144P9.
KW   Complete proteome; Pyrimidine biosynthesis; Reference proteome;
KW   Transferase.
FT   CHAIN         1    341       Aspartate carbamoyltransferase.
FT                                /FTId=PRO_0000321082.
SQ   SEQUENCE   341 AA;  37256 MW;  45EBC8562C10B0AB CRC64;
     MNTATQAPKD SADSATERFR YGFLKGNPQL TKNGELKHLL SIEGLPKAIV NHILDTADQF
     VSVTDREVKK VPLLRGKSVF NLFFENSTRT RTTFEIAATR LSADVLNLNI NASSTSKGES
     LLDTINNLSA MHADMFVVRH ASSGAPYLIA QHCAPHVHVI NAGDGRHAHP TQGLLDMYTI
     RHYKKDFTKL RVAIVGDILH SRVARSDIHA LTTLGVPEVR AIGPRTLLPG GLEQMGVRVF
     HNLDEGLKDV DVIIMLRLQN ERMSGALLPS AQEYFKSWGL TPERLALAAP EAIVMHPGPM
     NRGVEIDSQV ADGPQSVILN QVTFGIAVRM AVMGIVAGNH D
//

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