(data stored in ACNUC7421 zone)

SWISSPROT: Q144P6_PARXL

ID   Q144P6_PARXL            Unreviewed;       292 AA.
AC   Q144P6;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   08-MAY-2019, entry version 86.
DE   RecName: Full=Bis(5'-nucleosyl)-tetraphosphatase, symmetrical {ECO:0000256|HAMAP-Rule:MF_00199, ECO:0000256|SAAS:SAAS00768703};
DE            EC=3.6.1.41 {ECO:0000256|HAMAP-Rule:MF_00199, ECO:0000256|SAAS:SAAS00768707};
DE   AltName: Full=Ap4A hydrolase {ECO:0000256|HAMAP-Rule:MF_00199};
DE   AltName: Full=Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase {ECO:0000256|HAMAP-Rule:MF_00199};
DE   AltName: Full=Diadenosine tetraphosphatase {ECO:0000256|HAMAP-Rule:MF_00199};
GN   Name=apaH {ECO:0000256|HAMAP-Rule:MF_00199};
GN   ORFNames=Bxe_A3805 {ECO:0000313|EMBL:ABE29193.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE29193.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE29193.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE29193.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- FUNCTION: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to
CC       yield ADP. {ECO:0000256|HAMAP-Rule:MF_00199,
CC       ECO:0000256|SAAS:SAAS00768709}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = 2 ADP +
CC         2 H(+); Xref=Rhea:RHEA:24252, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58141, ChEBI:CHEBI:456216;
CC         EC=3.6.1.41; Evidence={ECO:0000256|HAMAP-Rule:MF_00199,
CC         ECO:0000256|SAAS:SAAS01124567};
CC   -!- SIMILARITY: Belongs to the Ap4A hydrolase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00199, ECO:0000256|SAAS:SAAS00768708}.
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DR   EMBL; CP000270; ABE29193.1; -; Genomic_DNA.
DR   RefSeq; WP_011486990.1; NZ_CP008760.1.
DR   STRING; 266265.Bxe_A3805; -.
DR   EnsemblBacteria; ABE29193; ABE29193; Bxe_A3805.
DR   GeneID; 4002581; -.
DR   KEGG; bxb:DR64_1482; -.
DR   KEGG; bxe:Bxe_A3805; -.
DR   PATRIC; fig|266265.5.peg.684; -.
DR   eggNOG; ENOG4105DDT; Bacteria.
DR   eggNOG; COG0639; LUCA.
DR   HOGENOM; HOG000251871; -.
DR   KO; K01525; -.
DR   OMA; MPWFDVP; -.
DR   OrthoDB; 900869at2; -.
DR   BioCyc; BXEN266265:BXE_RS03235-MONOMER; -.
DR   Proteomes; UP000001817; Chromosome 1.
DR   GO; GO:0008803; F:bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity; IEA:UniProtKB-UniRule.
DR   CDD; cd07422; MPP_ApaH; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   HAMAP; MF_00199; ApaH; 1.
DR   InterPro; IPR004617; ApaH.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF00149; Metallophos; 1.
DR   PIRSF; PIRSF000903; B5n-ttraPtase_sm; 1.
DR   TIGRFAMs; TIGR00668; apaH; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q144P6.
DR   SWISS-2DPAGE; Q144P6.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001817};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00199,
KW   ECO:0000256|SAAS:SAAS00768706};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001817}.
FT   DOMAIN       18    144       Metallophos. {ECO:0000259|Pfam:PF00149}.
SQ   SEQUENCE   292 AA;  31184 MW;  4AD25BF77D7B9456 CRC64;
     MTPATSSPAP SGQPLVPLAF GDLQGCRTPF QQLLAKAAPP AGTPLWFAGD LINRGAESLA
     TLRDVIALGE RAVPVLGNHD LHLLSVSAGI RKSKKGDTID EILTAPDAAD LLDWVRHRPL
     AHFDNGMLMV HAGVLPQWDV TMTLELADEL HRALCAPNWK ETLAGLYGNE PNRWKPGLKG
     IERLRLTCSA LTRMRFCTAE GVMDFSSSGG LNAAPPGCMP WFDVPSRETA GVTVVFGHWA
     ALGLTLRDNL IGLDSGCVWG EKLSAVRLAQ NPAERTLTQV GCENCRAPGG GN
//

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