(data stored in ACNUC7421 zone)

SWISSPROT: Q13S43_PARXL

ID   Q13S43_PARXL            Unreviewed;       338 AA.
AC   Q13S43;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   30-AUG-2017, entry version 80.
DE   SubName: Full=Lyase {ECO:0000313|EMBL:ABE33096.1};
DE            EC=4.1.3.6 {ECO:0000313|EMBL:ABE33096.1};
GN   ORFNames=Bxe_B2899 {ECO:0000313|EMBL:ABE33096.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE33096.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE33096.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE33096.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
RN   [2] {ECO:0000213|PDB:3R4I}
RP   X-RAY CRYSTALLOGRAPHY (2.24 ANGSTROMS) IN COMPLEX WITH CALCIUM.
RG   Joint Center for Structural Genomics (JCSG);
RT   "Crystal structure of a Citrate lyase (Bxe_B2899) from BURKHOLDERIA
RT   XENOVORANS LB400 at 2.24 A resolution.";
RL   Submitted (MAR-2011) to the PDB data bank.
CC   -!- SIMILARITY: Belongs to the HpcH/HpaI aldolase family.
CC       {ECO:0000256|SAAS:SAAS00571010}.
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DR   EMBL; CP000271; ABE33096.1; -; Genomic_DNA.
DR   RefSeq; WP_011490480.1; NZ_CP008762.1.
DR   PDB; 3R4I; X-ray; 2.24 A; A/B/C/D/E/F=1-338.
DR   PDBsum; 3R4I; -.
DR   ProteinModelPortal; Q13S43; -.
DR   SMR; Q13S43; -.
DR   STRING; 266265.Bxe_B2899; -.
DR   DNASU; 4006736; -.
DR   EnsemblBacteria; ABE33096; ABE33096; Bxe_B2899.
DR   GeneID; 4006736; -.
DR   KEGG; bxb:DR64_5228; -.
DR   KEGG; bxe:Bxe_B2899; -.
DR   PATRIC; fig|266265.5.peg.4789; -.
DR   eggNOG; ENOG4105DYX; Bacteria.
DR   eggNOG; COG2301; LUCA.
DR   HOGENOM; HOG000160138; -.
DR   KO; K01644; -.
DR   OMA; VCDHYAG; -.
DR   OrthoDB; POG091H0AO0; -.
DR   Proteomes; UP000001817; Chromosome 2.
DR   GO; GO:0008815; F:citrate (pro-3S)-lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR005000; Aldolase/citrate-lyase_domain.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   Pfam; PF03328; HpcH_HpaI; 1.
DR   SUPFAM; SSF51621; SSF51621; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q13S43.
DR   SWISS-2DPAGE; Q13S43.
KW   3D-structure {ECO:0000213|PDB:3R4I}; Calcium {ECO:0000213|PDB:3R4I};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001817};
KW   Lyase {ECO:0000313|EMBL:ABE33096.1};
KW   Metal-binding {ECO:0000213|PDB:3R4I, ECO:0000256|SAAS:SAAS00088067};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001817}.
FT   DOMAIN       49    255       HpcH_HpaI. {ECO:0000259|Pfam:PF03328}.
FT   METAL       151    151       Calcium 1. {ECO:0000213|PDB:3R4I}.
FT   METAL       151    151       Calcium 2. {ECO:0000213|PDB:3R4I}.
FT   METAL       177    177       Calcium 1. {ECO:0000213|PDB:3R4I}.
FT   METAL       177    177       Calcium 2. {ECO:0000213|PDB:3R4I}.
FT   METAL       230    230       Calcium 3. {ECO:0000213|PDB:3R4I}.
SQ   SEQUENCE   338 AA;  37098 MW;  9537DF5984C2DAE1 CRC64;
     MRALTPAEVL FDGEVPPAVL PACDHYAGSE KLMLKSLALQ QQLGPVFDIT LDCEDGAQVG
     REAQHAELVA SLLGSEHDRF GRVGVRIHDF DHAHWRDDVR LILRAAKRAP AYITLPKIRH
     VHDAAEMVAF IEATRRELGI AQPVPVQLLV ETHGALTRVF DLAALPGVEA LSFGLMDFVS
     AHDGAIPDTA MRSPGQFDHP LVRRAKLEIS AACHAYGKVP SHNVSTEVRD MSVVANDAAR
     ARNEFGYTRM WSIHPAQIEA IVAAFAPRDE EITTATEILL AAQSAQWGPT RYHDTLHDRA
     SYRYYWSVLR RAQATGRAVP QDAAPLFTKV GTNVQAAS
//

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