(data stored in ACNUC7421 zone)

SWISSPROT: Q13S26_PARXL

ID   Q13S26_PARXL            Unreviewed;       237 AA.
AC   Q13S26;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   07-JUN-2017, entry version 82.
DE   RecName: Full=N-(5'-phosphoribosyl)anthranilate isomerase {ECO:0000256|HAMAP-Rule:MF_00135, ECO:0000256|SAAS:SAAS00786583};
DE            Short=PRAI {ECO:0000256|HAMAP-Rule:MF_00135};
DE            EC=5.3.1.24 {ECO:0000256|HAMAP-Rule:MF_00135, ECO:0000256|SAAS:SAAS00786604};
GN   Name=trpF {ECO:0000256|HAMAP-Rule:MF_00135};
GN   ORFNames=Bxe_B2882 {ECO:0000313|EMBL:ABE33113.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE33113.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE33113.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE33113.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- CATALYTIC ACTIVITY: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-
CC       (2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
CC       {ECO:0000256|HAMAP-Rule:MF_00135}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 3/5. {ECO:0000256|HAMAP-
CC       Rule:MF_00135}.
CC   -!- SIMILARITY: Belongs to the TrpF family. {ECO:0000256|HAMAP-
CC       Rule:MF_00135, ECO:0000256|SAAS:SAAS00786582}.
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DR   EMBL; CP000271; ABE33113.1; -; Genomic_DNA.
DR   RefSeq; WP_011490496.1; NZ_CP008762.1.
DR   ProteinModelPortal; Q13S26; -.
DR   STRING; 266265.Bxe_B2882; -.
DR   EnsemblBacteria; ABE33113; ABE33113; Bxe_B2882.
DR   GeneID; 4006753; -.
DR   KEGG; bxb:DR64_5212; -.
DR   KEGG; bxe:Bxe_B2882; -.
DR   PATRIC; fig|266265.5.peg.4807; -.
DR   eggNOG; ENOG4108ZGB; Bacteria.
DR   eggNOG; COG0135; LUCA.
DR   HOGENOM; HOG000161598; -.
DR   KO; K01817; -.
DR   OMA; FYAKSPR; -.
DR   OrthoDB; POG091H01PA; -.
DR   UniPathway; UPA00035; UER00042.
DR   Proteomes; UP000001817; Chromosome 2.
DR   GO; GO:0004640; F:phosphoribosylanthranilate isomerase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-HAMAP.
DR   CDD; cd00405; PRAI; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00135; PRAI; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR001240; PRAI.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   Pfam; PF00697; PRAI; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q13S26.
DR   SWISS-2DPAGE; Q13S26.
KW   Amino-acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_00135};
KW   Aromatic amino acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_00135};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001817};
KW   Isomerase {ECO:0000256|HAMAP-Rule:MF_00135,
KW   ECO:0000313|EMBL:ABE33113.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001817};
KW   Tryptophan biosynthesis {ECO:0000256|HAMAP-Rule:MF_00135}.
FT   DOMAIN       27    229       PRAI. {ECO:0000259|Pfam:PF00697}.
SQ   SEQUENCE   237 AA;  24781 MW;  EE25E2AAD7F3EE40 CRC64;
     MKSTENLARE SSSGMEQLPA PHRTRIKLCG LSKPEDVAHA IDLGADAIGL VFYPPSPRSV
     SVAQAVELVR DVPPFVSVVG LFVNATPDWI REVVSNVGLT LLQFHGDETA GQCESLAGVA
     GLPWLRALRV AADTQPADLV KSALSYSAAS GLLFDTHVEG YGGGGKVFDW SLIPAGLARR
     AVLSGGLSAQ NVSDAIHCVR PYAVDVSSGI ESPGAKGVKD HARMAAFVRA VRAADAE
//

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