(data stored in ACNUC7421 zone)

SWISSPROT: Q13RW4_PARXL

ID   Q13RW4_PARXL            Unreviewed;       680 AA.
AC   Q13RW4;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   05-JUL-2017, entry version 83.
DE   RecName: Full=RNA polymerase sigma factor RpoD {ECO:0000256|HAMAP-Rule:MF_00963};
DE   AltName: Full=Sigma-70 {ECO:0000256|HAMAP-Rule:MF_00963};
GN   Name=rpoD {ECO:0000256|HAMAP-Rule:MF_00963};
GN   ORFNames=Bxe_B2820 {ECO:0000313|EMBL:ABE33175.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE33175.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE33175.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE33175.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- FUNCTION: Sigma factors are initiation factors that promote the
CC       attachment of RNA polymerase to specific initiation sites and are
CC       then released. This sigma factor is the primary sigma factor
CC       during exponential growth. {ECO:0000256|SAAS:SAAS00535554}.
CC   -!- SUBUNIT: Interacts transiently with the RNA polymerase catalytic
CC       core. {ECO:0000256|HAMAP-Rule:MF_00963,
CC       ECO:0000256|SAAS:SAAS00003340}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00963,
CC       ECO:0000256|SAAS:SAAS00003349}.
CC   -!- SIMILARITY: Belongs to the sigma-70 factor family. RpoD/SigA
CC       subfamily. {ECO:0000256|SAAS:SAAS00535555}.
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DR   EMBL; CP000271; ABE33175.1; -; Genomic_DNA.
DR   ProteinModelPortal; Q13RW4; -.
DR   STRING; 266265.Bxe_B2820; -.
DR   EnsemblBacteria; ABE33175; ABE33175; Bxe_B2820.
DR   KEGG; bxb:DR64_5149; -.
DR   KEGG; bxe:Bxe_B2820; -.
DR   PATRIC; fig|266265.5.peg.4873; -.
DR   eggNOG; ENOG4105DG1; Bacteria.
DR   eggNOG; COG0568; LUCA.
DR   HOGENOM; HOG000270272; -.
DR   KO; K03086; -.
DR   OMA; AICSVPY; -.
DR   OrthoDB; POG091H0012; -.
DR   Proteomes; UP000001817; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0016987; F:sigma factor activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0001123; P:transcription initiation from bacterial-type RNA polymerase promoter; IEA:UniProtKB-HAMAP.
DR   Gene3D; 1.10.10.10; -; 2.
DR   HAMAP; MF_00963; Sigma70_RpoD_SigA; 1.
DR   InterPro; IPR014284; RNA_pol_sigma-70_dom.
DR   InterPro; IPR000943; RNA_pol_sigma70.
DR   InterPro; IPR009042; RNA_pol_sigma70_r1_2.
DR   InterPro; IPR007627; RNA_pol_sigma70_r2.
DR   InterPro; IPR007624; RNA_pol_sigma70_r3.
DR   InterPro; IPR007630; RNA_pol_sigma70_r4.
DR   InterPro; IPR007631; RNA_pol_sigma_70_non-ess.
DR   InterPro; IPR007127; RNA_pol_sigma_70_r1_1.
DR   InterPro; IPR013325; RNA_pol_sigma_r2.
DR   InterPro; IPR013324; RNA_pol_sigma_r3_r4.
DR   InterPro; IPR012760; RNA_pol_sigma_RpoD_C.
DR   InterPro; IPR028630; Sigma70_RpoD.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   Pfam; PF04546; Sigma70_ner; 1.
DR   Pfam; PF03979; Sigma70_r1_1; 1.
DR   Pfam; PF00140; Sigma70_r1_2; 1.
DR   Pfam; PF04542; Sigma70_r2; 1.
DR   Pfam; PF04539; Sigma70_r3; 1.
DR   Pfam; PF04545; Sigma70_r4; 1.
DR   PRINTS; PR00046; SIGMA70FCT.
DR   SUPFAM; SSF88659; SSF88659; 2.
DR   SUPFAM; SSF88946; SSF88946; 1.
DR   TIGRFAMs; TIGR02393; RpoD_Cterm; 1.
DR   TIGRFAMs; TIGR02937; sigma70-ECF; 1.
DR   PROSITE; PS00715; SIGMA70_1; 1.
DR   PROSITE; PS00716; SIGMA70_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q13RW4.
DR   SWISS-2DPAGE; Q13RW4.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001817};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00963,
KW   ECO:0000256|SAAS:SAAS00051776};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00963,
KW   ECO:0000256|SAAS:SAAS00611263};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001817};
KW   Sigma factor {ECO:0000256|HAMAP-Rule:MF_00963,
KW   ECO:0000256|SAAS:SAAS00611278};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_00963,
KW   ECO:0000256|SAAS:SAAS00611290};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_00963,
KW   ECO:0000256|SAAS:SAAS00611294}.
FT   DOMAIN      469    482       RNA_pol_sigma70. {ECO:0000259|PROSITE:
FT                                PS00715}.
FT   DOMAIN      638    664       RNA_pol_sigma70. {ECO:0000259|PROSITE:
FT                                PS00716}.
FT   DNA_BIND    639    658       H-T-H motif. {ECO:0000256|HAMAP-Rule:
FT                                MF_00963}.
FT   REGION      445    515       Sigma-70 factor domain-2.
FT                                {ECO:0000256|HAMAP-Rule:MF_00963}.
FT   REGION      524    600       Sigma-70 factor domain-3.
FT                                {ECO:0000256|HAMAP-Rule:MF_00963}.
FT   REGION      613    666       Sigma-70 factor domain-4.
FT                                {ECO:0000256|HAMAP-Rule:MF_00963}.
FT   COILED      424    451       {ECO:0000256|SAM:Coils}.
FT   MOTIF       469    472       Interaction with polymerase core subunit
FT                                RpoC. {ECO:0000256|HAMAP-Rule:MF_00963}.
SQ   SEQUENCE   680 AA;  76928 MW;  9D36F5F01EBD617B CRC64;
     MTKKLNEVPV DDDATQSEEN PAAVPAKVEK AKARDRRAKE KALLKDAFAS SQPGTVEELE
     ERRSKLRALI KLGKERGFLT YAEINDHLPD NFTETEAIEG IISTFNDMGV AVYEQAPDAE
     TLLLNDNAPA ASSDDEVEEE AEVALSTVDS EFGRTTDPVR MYMREMGTVE LLTREGEIEI
     AKRIEDGLKH MVMAISACPT TIADILAMAE RVANEEIRID ELVDGLIDAN AEDADGFSAQ
     EAEAIESEDE EVEEDSEEDE EEDDGTAQAT ANAAQMEALK RASLEKFAMI SEWFDKMRRA
     FEKEGYKSKS YLKAQETIQN ELMTIRFTAR TVERLCDTLR AQVDEVRQVE RQILHTVVDK
     CGMPRAEFIA RFPGSETDLE WADKIVGEGH AYSAILTRNI PAIREQQQRL LDLQARVVLP
     LKDLKETNRQ MAAGELKARQ AKREMTEANL RLVISIAKKY TNRGLQFLDL IQEGNIGLMK
     AVDKFEYRRG YKFSTYATWW IRQAITRSIA DQARTIRIPV HMIETINKMN RISRQILQET
     GLEPDPATLA EKMEMPEDKI RKIMKIAKEP ISMETPIGDD DDSHLGDFIE DNNTVAPADA
     ALHASMRDVV KDVLDSLTPR EAKVLRMRFG IEMSTDHTLE EVGKQFDVTR ERIRQIEAKA
     LRKLRHPSRS DKLKSFLEGN
//

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