(data stored in ACNUC7421 zone)

SWISSPROT: XYLA_PARXL

ID   XYLA_PARXL              Reviewed;         440 AA.
AC   Q13RB8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   07-JUN-2017, entry version 74.
DE   RecName: Full=Xylose isomerase {ECO:0000255|HAMAP-Rule:MF_00455};
DE            EC=5.3.1.5 {ECO:0000255|HAMAP-Rule:MF_00455};
GN   Name=xylA {ECO:0000255|HAMAP-Rule:MF_00455};
GN   OrderedLocusNames=Bxeno_B0403; ORFNames=Bxe_B2622;
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400;
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- CATALYTIC ACTIVITY: D-xylopyranose = D-xylulose.
CC       {ECO:0000255|HAMAP-Rule:MF_00455}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00455};
CC       Note=Binds 2 magnesium ions per subunit. {ECO:0000255|HAMAP-
CC       Rule:MF_00455};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_00455}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00455}.
CC   -!- SIMILARITY: Belongs to the xylose isomerase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00455}.
DR   EMBL; CP000271; ABE33371.1; -; Genomic_DNA.
DR   RefSeq; WP_011490740.1; NZ_CP008762.1.
DR   ProteinModelPortal; Q13RB8; -.
DR   SMR; Q13RB8; -.
DR   STRING; 266265.Bxe_B2622; -.
DR   EnsemblBacteria; ABE33371; ABE33371; Bxe_B2622.
DR   GeneID; 4006662; -.
DR   KEGG; bxb:DR64_4955; -.
DR   KEGG; bxe:Bxe_B2622; -.
DR   PATRIC; fig|266265.5.peg.5079; -.
DR   eggNOG; ENOG4105C93; Bacteria.
DR   eggNOG; COG2115; LUCA.
DR   HOGENOM; HOG000252293; -.
DR   KO; K01805; -.
DR   OMA; HTFQHEL; -.
DR   OrthoDB; POG091H07LC; -.
DR   Proteomes; UP000001817; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009045; F:xylose isomerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0042732; P:D-xylose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-KW.
DR   HAMAP; MF_00455; Xylose_isom_A; 1.
DR   InterPro; IPR013022; Xyl_isomerase-like_TIM-brl.
DR   InterPro; IPR013452; Xylose_isom_bac.
DR   InterPro; IPR001998; Xylose_isomerase.
DR   PANTHER; PTHR32176:SF23; PTHR32176:SF23; 1.
DR   PRINTS; PR00688; XYLOSISMRASE.
DR   SUPFAM; SSF51658; SSF51658; 1.
DR   TIGRFAMs; TIGR02630; xylose_isom_A; 1.
DR   PROSITE; PS51415; XYLOSE_ISOMERASE; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q13RB8.
DR   SWISS-2DPAGE; Q13RB8.
KW   Carbohydrate metabolism; Complete proteome; Cytoplasm; Isomerase;
KW   Magnesium; Metal-binding; Pentose shunt; Reference proteome;
KW   Xylose metabolism.
FT   CHAIN         1    440       Xylose isomerase.
FT                                /FTId=PRO_1000026437.
FT   ACT_SITE    100    100       {ECO:0000255|HAMAP-Rule:MF_00455}.
FT   ACT_SITE    103    103       {ECO:0000255|HAMAP-Rule:MF_00455}.
FT   METAL       231    231       Magnesium 1. {ECO:0000255|HAMAP-
FT                                Rule:MF_00455}.
FT   METAL       267    267       Magnesium 1. {ECO:0000255|HAMAP-
FT                                Rule:MF_00455}.
FT   METAL       267    267       Magnesium 2. {ECO:0000255|HAMAP-
FT                                Rule:MF_00455}.
FT   METAL       270    270       Magnesium 2. {ECO:0000255|HAMAP-
FT                                Rule:MF_00455}.
FT   METAL       295    295       Magnesium 1. {ECO:0000255|HAMAP-
FT                                Rule:MF_00455}.
FT   METAL       306    306       Magnesium 2. {ECO:0000255|HAMAP-
FT                                Rule:MF_00455}.
FT   METAL       308    308       Magnesium 2. {ECO:0000255|HAMAP-
FT                                Rule:MF_00455}.
FT   METAL       338    338       Magnesium 1. {ECO:0000255|HAMAP-
FT                                Rule:MF_00455}.
SQ   SEQUENCE   440 AA;  49775 MW;  65BE1A8AB9BE1914 CRC64;
     MSYFEHIPEI RYEGPQSDNP LAYRHYDKSK KVLGKTLEEH LRIAVCYWHT FVWPGVDIFG
     QGTFRRPWQQ AGDAMERARQ KADSAFEFFS KLGTPYYTFH DTDVSPEGSS LKEYSENFLR
     ITDYLARKQE DTGIKLLWGT ANLFSHPRYA AGAATSPDPE VFAFAATQVR HALDATQRLG
     GDNYVLWGGR EGYDTLLNTD LMRERDQLAR FLHMVVDHAH KIGFKGSLLI EPKPQEPTKH
     QYDYDVATVH GFLLQHGLEK EIRVNIEANH ATLAGHSFHH EIATAYALGI FGSVDANRGD
     PQNGWDTDQF PNSVEELTLA FYEILKHGGF TTGGMNFDSK VRRQSVDPED LFYGHIGAID
     NLALAVERAA VLIENDRLDQ FKRQRYAGWD ADFGRKILSG DYSLSTLATD ALARGLNPQH
     ASGHQELMEN IVNQAIYSGR
//

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