(data stored in ACNUC7421 zone)

SWISSPROT: Q13R56_PARXL

ID   Q13R56_PARXL            Unreviewed;       496 AA.
AC   Q13R56;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   07-JUN-2017, entry version 50.
DE   RecName: Full=Microcystinase C {ECO:0000256|PIRNR:PIRNR012702};
DE            Short=MlrC {ECO:0000256|PIRNR:PIRNR012702};
GN   ORFNames=Bxe_B2560 {ECO:0000313|EMBL:ABE33433.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE33433.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE33433.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE33433.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- FUNCTION: Involved in peptidolytic degradation of cyclic
CC       heptapeptide hepatotoxin microcystin (MC).
CC       {ECO:0000256|PIRNR:PIRNR012702}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|PIRNR:PIRNR012702};
CC       Note=Binds 1 zinc ion per subunit.
CC       {ECO:0000256|PIRNR:PIRNR012702};
CC   -!- SIMILARITY: Belongs to the peptidase M81 family.
CC       {ECO:0000256|PIRNR:PIRNR012702}.
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DR   EMBL; CP000271; ABE33433.1; -; Genomic_DNA.
DR   RefSeq; WP_011490801.1; NZ_CP008762.1.
DR   STRING; 266265.Bxe_B2560; -.
DR   EnsemblBacteria; ABE33433; ABE33433; Bxe_B2560.
DR   GeneID; 4006943; -.
DR   KEGG; bxb:DR64_4887; -.
DR   KEGG; bxe:Bxe_B2560; -.
DR   PATRIC; fig|266265.5.peg.5143; -.
DR   eggNOG; ENOG4107A6K; Bacteria.
DR   eggNOG; COG5476; LUCA.
DR   HOGENOM; HOG000267180; -.
DR   OMA; FKEFPHT; -.
DR   OrthoDB; POG091H0ED6; -.
DR   Proteomes; UP000001817; Chromosome 2.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR009197; MlrC.
DR   InterPro; IPR010799; MlrC_C.
DR   InterPro; IPR015995; MlrC_N.
DR   Pfam; PF07364; DUF1485; 1.
DR   Pfam; PF07171; MlrC_C; 1.
DR   PIRSF; PIRSF012702; UCP012702; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q13R56.
DR   SWISS-2DPAGE; Q13R56.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001817};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR012702};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR012702};
KW   Metalloprotease {ECO:0000256|PIRNR:PIRNR012702};
KW   Protease {ECO:0000256|PIRNR:PIRNR012702};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001817}.
FT   DOMAIN        2    285       DUF1485. {ECO:0000259|Pfam:PF07364}.
FT   DOMAIN      298    476       MlrC_C. {ECO:0000259|Pfam:PF07171}.
SQ   SEQUENCE   496 AA;  52425 MW;  8ADE3A1687BABF16 CRC64;
     MKILIARMNH ETNTFSPVAT PLAAFGRNGP SYGEDAFTEN KGMQTAMAAF IDAAEKEHAE
     IVTPVSASAN PSGPVEAAAY AAICESIVSA AAGCDAVMLD LHGAMVAENS NDGEGDLLER
     VRALLPDAPI AVALDLHGNV TQKMIDNADV IVSFKTYPHV DMYETGAHAA RLLFDLIHGK
     AKPVIAWRQP PLLTHTLRSA TAEGAMKRAV DAARAAEADG MLAVSVLSGF SLADIAAPCI
     SVVVVGNGER AEAEAVAERI ARQIWDERED FVYRSAPLAD SVAQAATLAV NADKPVLLLD
     HGDNCMSGGT CDTMDLLEEA LKQKLDGIVS GPLCDPQAVA ALMAAGVGST VTVTIGNKIA
     SDALKPRSPL AVTGVVRALT DGEYVISGPT YTGQRAFMGR AAVLDTGAVK LVITERTHEP
     WDLGVFESVG IDPRRARFLL LKSRMYCRPV FVPIAAALVE CDSRGVTSSD YGLFAFAHVK
     RPVYPLDTQT EWAVTN
//

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