(data stored in ACNUC7421 zone)

SWISSPROT: Q13QW4_PARXL

ID   Q13QW4_PARXL            Unreviewed;       346 AA.
AC   Q13QW4;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   07-JUN-2017, entry version 73.
DE   RecName: Full=Proline iminopeptidase {ECO:0000256|PIRNR:PIRNR006431};
DE            Short=PIP {ECO:0000256|PIRNR:PIRNR006431};
DE            EC=3.4.11.5 {ECO:0000256|PIRNR:PIRNR006431};
DE   AltName: Full=Prolyl aminopeptidase {ECO:0000256|PIRNR:PIRNR006431};
GN   ORFNames=Bxe_B2466 {ECO:0000313|EMBL:ABE33525.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE33525.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE33525.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE33525.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- CATALYTIC ACTIVITY: Release of N-terminal proline from a peptide.
CC       {ECO:0000256|PIRNR:PIRNR006431}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR006431}.
CC   -!- SIMILARITY: Belongs to the peptidase S33 family.
CC       {ECO:0000256|PIRNR:PIRNR006431}.
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DR   EMBL; CP000271; ABE33525.1; -; Genomic_DNA.
DR   RefSeq; WP_011490891.1; NZ_CP008762.1.
DR   ProteinModelPortal; Q13QW4; -.
DR   STRING; 266265.Bxe_B2466; -.
DR   ESTHER; burxl-q13qw4; Proline_iminopeptidase.
DR   MEROPS; S33.001; -.
DR   EnsemblBacteria; ABE33525; ABE33525; Bxe_B2466.
DR   GeneID; 4007038; -.
DR   KEGG; bxb:DR64_4793; -.
DR   KEGG; bxe:Bxe_B2466; -.
DR   PATRIC; fig|266265.5.peg.5243; -.
DR   HOGENOM; HOG000171480; -.
DR   KO; K01259; -.
DR   OMA; YDLLCPP; -.
DR   OrthoDB; POG091H04PE; -.
DR   Proteomes; UP000001817; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR002410; Peptidase_S33.
DR   InterPro; IPR005944; Pro_iminopeptidase.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   PIRSF; PIRSF006431; Pept_S33; 1.
DR   PRINTS; PR00111; ABHYDROLASE.
DR   PRINTS; PR00793; PROAMNOPTASE.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q13QW4.
DR   SWISS-2DPAGE; Q13QW4.
KW   Aminopeptidase {ECO:0000256|PIRNR:PIRNR006431,
KW   ECO:0000313|EMBL:ABE33525.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001817};
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR006431};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR006431,
KW   ECO:0000313|EMBL:ABE33525.1};
KW   Protease {ECO:0000256|PIRNR:PIRNR006431};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001817}.
FT   DOMAIN       48    314       AB hydrolase-1 (Alpha/Beta hydrolase fold
FT                                1). {ECO:0000259|Pfam:PF00561}.
FT   ACT_SITE    122    122       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR006431-1}.
FT   ACT_SITE    285    285       {ECO:0000256|PIRSR:PIRSR006431-1}.
FT   ACT_SITE    312    312       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR006431-1}.
SQ   SEQUENCE   346 AA;  37226 MW;  8C6AC19A6897F76D CRC64;
     MMRHASKSGS RPGARQASPQ APLTVDALRT RDGHRVSFSV AGAADGVPVV VLHGGPGSGS
     QPGALGLFDL TRFRVVLIDQ RGTGASTPHG SVRHNRTDRL IEDIEAIRVR LGVERWGVLG
     GSWGAALALA YAGRHPQSVT GVVMRGLFLT SSREVRGLFV TARKRAPRAW SQLCAAAQCD
     RPAALLARCH ARLQRGANAN QAQQHALALA WRGYENAVLA SATSRRSRSP TRSSRQDTRK
     LIGKYRIQAH YLMHRCWLGE TRLLSLARGA AAAGVPLAAV HGSRDPVCPP DNLRRLARAV
     SAARVEYVRA GHLASDPKLH ERVAAALAMM FLPTAHDEGR VLRRAA
//

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