(data stored in ACNUC7421 zone)

SWISSPROT: Q13QW1_PARXL

ID   Q13QW1_PARXL            Unreviewed;       319 AA.
AC   Q13QW1;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   07-JUN-2017, entry version 76.
DE   RecName: Full=Formylmethanofuran--tetrahydromethanopterin formyltransferase {ECO:0000256|HAMAP-Rule:MF_00579};
DE            EC=2.3.1.101 {ECO:0000256|HAMAP-Rule:MF_00579};
DE   AltName: Full=H4MPT formyltransferase {ECO:0000256|HAMAP-Rule:MF_00579};
GN   Name=fhcD {ECO:0000313|EMBL:ABE33528.1};
GN   Synonyms=ffsA {ECO:0000256|HAMAP-Rule:MF_00579};
GN   ORFNames=Bxe_B2463 {ECO:0000313|EMBL:ABE33528.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE33528.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE33528.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE33528.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- FUNCTION: Catalyzes the transfer of a formyl group from 5-formyl
CC       tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR)
CC       so as to produce formylmethanofuran (formyl-MFR) and
CC       tetrahydromethanopterin (H(4)MPT). {ECO:0000256|HAMAP-
CC       Rule:MF_00579}.
CC   -!- CATALYTIC ACTIVITY: Formylmethanofuran + 5,6,7,8-
CC       tetrahydromethanopterin = methanofuran + 5-formyl-5,6,7,8-
CC       tetrahydromethanopterin. {ECO:0000256|HAMAP-Rule:MF_00579}.
CC   -!- PATHWAY: One-carbon metabolism; formaldehyde degradation; formate
CC       from formaldehyde (H(4)MPT route): step 4/5. {ECO:0000256|HAMAP-
CC       Rule:MF_00579}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00579}.
CC   -!- SIMILARITY: Belongs to the FTR family. {ECO:0000256|HAMAP-
CC       Rule:MF_00579}.
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DR   EMBL; CP000271; ABE33528.1; -; Genomic_DNA.
DR   RefSeq; WP_011490894.1; NZ_CP008762.1.
DR   ProteinModelPortal; Q13QW1; -.
DR   STRING; 266265.Bxe_B2463; -.
DR   EnsemblBacteria; ABE33528; ABE33528; Bxe_B2463.
DR   GeneID; 4007041; -.
DR   KEGG; bxb:DR64_4790; -.
DR   KEGG; bxe:Bxe_B2463; -.
DR   PATRIC; fig|266265.5.peg.5246; -.
DR   eggNOG; ENOG4105FIE; Bacteria.
DR   eggNOG; COG2037; LUCA.
DR   HOGENOM; HOG000230959; -.
DR   KO; K00672; -.
DR   OMA; LPNVIMP; -.
DR   OrthoDB; POG091H17SR; -.
DR   UniPathway; UPA00562; UER00704.
DR   Proteomes; UP000001817; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030270; F:formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0046294; P:formaldehyde catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.30.70.520; -; 2.
DR   HAMAP; MF_00579; FTR; 1.
DR   InterPro; IPR014053; ForMFR_H4MPT_ForTrfase.
DR   InterPro; IPR002770; ForMFR_H4MPT_ForTrfase_C.
DR   InterPro; IPR023447; ForMFR_H4MPT_ForTrfase_fd-like.
DR   InterPro; IPR022667; ForMFR_H4MPT_ForTrfase_N.
DR   Pfam; PF01913; FTR; 1.
DR   Pfam; PF02741; FTR_C; 1.
DR   PIRSF; PIRSF006414; Ftr_formyl_trnsf; 1.
DR   SUPFAM; SSF55112; SSF55112; 2.
DR   TIGRFAMs; TIGR03119; one_C_fhcD; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q13QW1.
DR   SWISS-2DPAGE; Q13QW1.
KW   Acyltransferase {ECO:0000256|HAMAP-Rule:MF_00579,
KW   ECO:0000313|EMBL:ABE33528.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001817};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00579};
KW   One-carbon metabolism {ECO:0000256|HAMAP-Rule:MF_00579};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001817};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00579,
KW   ECO:0000313|EMBL:ABE33528.1}.
FT   DOMAIN        7    156       FTR. {ECO:0000259|Pfam:PF01913}.
FT   DOMAIN      159    310       FTR_C. {ECO:0000259|Pfam:PF02741}.
SQ   SEQUENCE   319 AA;  32709 MW;  07CA9114D106E889 CRC64;
     MSEPATLQIN GTTIDATFAE AFPMKATRLV ITAHTPAWAM HAANSLTGFA TSVIGCGCEA
     GVERMLPAGQ TPDGRPGVTV LLFAVSSKEL AKQIERRVGQ CVLTCPTTAV YGGIDAGTSR
     APLSDRAPLG SALRFFGDGW QISKMLGDTR YWRVPVMDGE FVCEDTALTV KAVGGGNLIL
     LARDIDAALA AAEAAVAAMR RLPNVIMPFP GGVVRSGSKV GSKYKGASAS TNDAFCPTLT
     GLSARSELGA EVGCVLEIVI DGLTDTDVGA AMTAGIGAAA ESGRAAGLLR ISAGNYGGKL
     GPYHFYLHSL AAGLDGSRA
//

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