(data stored in ACNUC7421 zone)

SWISSPROT: Q13QT1_PARXL

ID   Q13QT1_PARXL            Unreviewed;       343 AA.
AC   Q13QT1;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   07-JUN-2017, entry version 70.
DE   RecName: Full=Methenyltetrahydromethanopterin cyclohydrolase {ECO:0000256|HAMAP-Rule:MF_00486};
DE            EC=3.5.4.27 {ECO:0000256|HAMAP-Rule:MF_00486};
DE   AltName: Full=Methenyl-H4MPT cyclohydrolase {ECO:0000256|HAMAP-Rule:MF_00486};
GN   Name=mch {ECO:0000256|HAMAP-Rule:MF_00486,
GN   ECO:0000313|EMBL:ABE33558.1};
GN   ORFNames=Bxe_B2433 {ECO:0000313|EMBL:ABE33558.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE33558.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE33558.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE33558.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- FUNCTION: Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-
CC       formyl-H(4)MPT. {ECO:0000256|HAMAP-Rule:MF_00486}.
CC   -!- CATALYTIC ACTIVITY: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin
CC       + H(2)O = 5-formyl-5,6,7,8-tetrahydromethanopterin.
CC       {ECO:0000256|HAMAP-Rule:MF_00486}.
CC   -!- PATHWAY: One-carbon metabolism; formaldehyde degradation; formate
CC       from formaldehyde (H(4)MPT route): step 3/5. {ECO:0000256|HAMAP-
CC       Rule:MF_00486}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00486}.
CC   -!- SIMILARITY: Belongs to the MCH family. {ECO:0000256|HAMAP-
CC       Rule:MF_00486}.
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DR   EMBL; CP000271; ABE33558.1; -; Genomic_DNA.
DR   RefSeq; WP_011490922.1; NZ_CP008762.1.
DR   ProteinModelPortal; Q13QT1; -.
DR   STRING; 266265.Bxe_B2433; -.
DR   EnsemblBacteria; ABE33558; ABE33558; Bxe_B2433.
DR   GeneID; 4007071; -.
DR   KEGG; bxb:DR64_4761; -.
DR   KEGG; bxe:Bxe_B2433; -.
DR   PATRIC; fig|266265.5.peg.5276; -.
DR   eggNOG; ENOG41068T5; Bacteria.
DR   eggNOG; COG3252; LUCA.
DR   HOGENOM; HOG000224079; -.
DR   KO; K01499; -.
DR   OMA; YFAMGSG; -.
DR   OrthoDB; POG091H09O5; -.
DR   UniPathway; UPA00562; UER00703.
DR   Proteomes; UP000001817; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0018759; F:methenyltetrahydromethanopterin cyclohydrolase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0046294; P:formaldehyde catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-HAMAP.
DR   CDD; cd00545; MCH; 1.
DR   HAMAP; MF_00486; McH; 1.
DR   InterPro; IPR003209; METHMP_CycHdrlase.
DR   Pfam; PF02289; MCH; 1.
DR   TIGRFAMs; TIGR03120; one_C_mch; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q13QT1.
DR   SWISS-2DPAGE; Q13QT1.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001817};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00486};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00486,
KW   ECO:0000313|EMBL:ABE33558.1};
KW   One-carbon metabolism {ECO:0000256|HAMAP-Rule:MF_00486};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001817}.
SQ   SEQUENCE   343 AA;  36122 MW;  132E3575F8BA98BB CRC64;
     MPSSNATPDA PRPPLAGAAA LSVNALSERL VSRLVDDAAR FGAAVSHAQN GTVLVDAGVM
     APGSVAAGVL IARICMGGLG HVTVRENLDA QPLWPSMIEV RTSWPVLACL GSQYAGWSLS
     ATKEQTGGKK FFSLGSGPAR ALAVKEPLFA ELGYRDTHER GVLVLEVDRL PPQVVIDKVL
     HDCGLAPERL TLVTTPTHSV AGTVQVVARV VEVALHKTHV LGVALDEVVE GGGSAPLPPP
     APDGIQAMGR TNDAILYGGR VHLTVKHDAV ARRLAAELPA STSRDYGRPF ADIFTSFNYD
     FYQIDPALFA PAEVWVSSLE SGATYHGGRV DTALLHDQWS GKP
//

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