(data stored in ACNUC7421 zone)

SWISSPROT: Q13QM4_PARXL

ID   Q13QM4_PARXL            Unreviewed;       573 AA.
AC   Q13QM4;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   07-JUN-2017, entry version 70.
DE   SubName: Full=Pyruvate dehydrogenase (Cytochrome) {ECO:0000313|EMBL:ABE33615.1};
GN   ORFNames=Bxe_B2374 {ECO:0000313|EMBL:ABE33615.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE33615.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE33615.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE33615.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|RuleBase:RU362132}.
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DR   EMBL; CP000271; ABE33615.1; -; Genomic_DNA.
DR   RefSeq; WP_011490976.1; NZ_CP008762.1.
DR   ProteinModelPortal; Q13QM4; -.
DR   STRING; 266265.Bxe_B2374; -.
DR   EnsemblBacteria; ABE33615; ABE33615; Bxe_B2374.
DR   GeneID; 4007130; -.
DR   KEGG; bxb:DR64_4706; -.
DR   KEGG; bxe:Bxe_B2374; -.
DR   PATRIC; fig|266265.5.peg.5337; -.
DR   eggNOG; ENOG4105C7K; Bacteria.
DR   eggNOG; COG0028; LUCA.
DR   HOGENOM; HOG000258444; -.
DR   KO; K00156; -.
DR   OMA; RGKEWIQ; -.
DR   OrthoDB; POG091H02KO; -.
DR   Proteomes; UP000001817; Chromosome 2.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   Gene3D; 3.40.50.1220; -; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR000399; TPP-bd_CS.
DR   InterPro; IPR011766; TPP_enzyme-bd_C.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   PROSITE; PS00187; TPP_ENZYMES; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q13QM4.
DR   SWISS-2DPAGE; Q13QM4.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001817};
KW   Pyruvate {ECO:0000313|EMBL:ABE33615.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001817};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN        5    170       TPP_enzyme_N. {ECO:0000259|Pfam:PF02776}.
FT   DOMAIN      191    318       TPP_enzyme_M. {ECO:0000259|Pfam:PF00205}.
FT   DOMAIN      381    527       TPP_enzyme_C. {ECO:0000259|Pfam:PF02775}.
SQ   SEQUENCE   573 AA;  60801 MW;  43687664F91881F0 CRC64;
     MASNTIAAYL ARTLAAAGVQ RIWGVTGDSL NGLAYSLDQV GSIRWMHTRH EEAAAFAAGA
     DAASSGRLAV CAGSCGPGNL HLINGLFDCH RNHQPVLAIA AHIPSSEIGL GYFQETHPQE
     LFKECSHYVE LVSSAAQFPR VLARAMRTAV EERGVAVIVL PGDVALSEGP SEAPSWTESA
     PPRIVPAEAD LDRLAALLNA SDAVTIMCGS GTQGAHDEVV ALADTLGAPV VHALRGKQFI
     EYDNPYDVGM TGLIGFSSGY HAMMSCDTLL LLGCDFPYRP FYPPDAKIIQ IDWKGSQLGH
     RAPLALGLVG TVKETVAATL PKLQRKTDRG FIDNARKHYA SARKGLDDLA TPAGAGRPIH
     PQYLAKMIDE SASDDAIFTA DVGTPTVWAA RYLTMNGKRQ LHGSFNHGSM ANAMPQALGA
     QGAHPGRQVV SLSGDGGLSM LLGDLLTARQ LDLPIKVVVF NNSLLGFVSM ELKAGGYLDT
     NVDLAKTDFA AIAKGAGIFG LRVEESEDVA GALRQVFDHP GPALLDVVTS KHELAMPPTI
     ELAQAKGFSL YMMRAILNGR GDEIVELART NLR
//

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