(data stored in ACNUC7421 zone)

SWISSPROT: Q13I89_PARXL

ID   Q13I89_PARXL            Unreviewed;       283 AA.
AC   Q13I89;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   08-MAY-2019, entry version 87.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:ABE36200.1};
DE            EC=1.1.1.35 {ECO:0000313|EMBL:ABE36200.1};
GN   ORFNames=Bxe_C0277 {ECO:0000313|EMBL:ABE36200.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE36200.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE36200.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE36200.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
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DR   EMBL; CP000272; ABE36200.1; -; Genomic_DNA.
DR   RefSeq; WP_011493460.1; NZ_CP008761.1.
DR   STRING; 266265.Bxe_C0277; -.
DR   EnsemblBacteria; ABE36200; ABE36200; Bxe_C0277.
DR   GeneID; 4009648; -.
DR   KEGG; bxb:DR64_8156; -.
DR   KEGG; bxe:Bxe_C0277; -.
DR   PATRIC; fig|266265.5.peg.8057; -.
DR   eggNOG; ENOG4105DYT; Bacteria.
DR   eggNOG; COG1250; LUCA.
DR   HOGENOM; HOG000141498; -.
DR   KO; K00074; -.
DR   OMA; MAHPMGP; -.
DR   OrthoDB; 862072at2; -.
DR   BioCyc; BXEN266265:BXE_RS38065-MONOMER; -.
DR   Proteomes; UP000001817; Chromosome 3.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR   InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   PIRSF; PIRSF000105; HCDH; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00067; 3HCDH; 1.
PE   4: Predicted;
DR   PRODOM; Q13I89.
DR   SWISS-2DPAGE; Q13I89.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001817};
KW   NAD {ECO:0000256|PIRSR:PIRSR000105-2};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00324627,
KW   ECO:0000313|EMBL:ABE36200.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001817}.
FT   DOMAIN        5    182       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      186    282       3HCDH. {ECO:0000259|Pfam:PF00725}.
FT   NP_BIND      10     15       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING      33     33       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING      49     49       Coenzyme A. {ECO:0000256|PIRSR:
FT                                PIRSR000105-3}.
FT   BINDING      56     56       Coenzyme A. {ECO:0000256|PIRSR:
FT                                PIRSR000105-3}.
FT   BINDING      92     92       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING      97     97       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING     119    119       Coenzyme A. {ECO:0000256|PIRSR:
FT                                PIRSR000105-3}.
FT   BINDING     119    119       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING     143    143       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING     274    274       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   SITE        140    140       Important for catalytic activity.
FT                                {ECO:0000256|PIRSR:PIRSR000105-1}.
SQ   SEQUENCE   283 AA;  29827 MW;  213F837E8D6650D2 CRC64;
     MSIQKVGVVG AGTMGNGIAQ VCAVAGLQVA MIDISGAAVT DGLATIESSL ERLVRKDKLS
     AADRAAALAR VSGNTDYAAL KGAGLIIEAA TENPGIKLRI LRQIDEAAED DAIIATNTSS
     ISITLLAAVL KQPERFIGMH FFNPVPMMAL LEVIRGLQTS DETHAKTLAF AQTIGKTAIT
     ARNSPGFAVN RILVPMINEA IFTLQEGLAT ADDIDTGMRL GCNHPIGPLA LADLIGLDTL
     LAVMQVFYEG FNDPKYRPAP LLREMVAAGR LGRKSGRGFH SYA
//

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