(data stored in ACNUC7421 zone)

SWISSPROT: Q13I86_PARXL

ID   Q13I86_PARXL            Unreviewed;       714 AA.
AC   Q13I86;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   08-MAY-2019, entry version 98.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:ABE36203.1};
DE            EC=1.1.1.35 {ECO:0000313|EMBL:ABE36203.1};
GN   ORFNames=Bxe_C0280 {ECO:0000313|EMBL:ABE36203.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE36203.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE36203.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE36203.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
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DR   EMBL; CP000272; ABE36203.1; -; Genomic_DNA.
DR   RefSeq; WP_011493463.1; NZ_CP008761.1.
DR   STRING; 266265.Bxe_C0280; -.
DR   EnsemblBacteria; ABE36203; ABE36203; Bxe_C0280.
DR   GeneID; 4009651; -.
DR   KEGG; bxb:DR64_8153; -.
DR   KEGG; bxe:Bxe_C0280; -.
DR   PATRIC; fig|266265.5.peg.8060; -.
DR   eggNOG; ENOG4105DYT; Bacteria.
DR   eggNOG; COG1250; LUCA.
DR   HOGENOM; HOG000261345; -.
DR   KO; K01782; -.
DR   OMA; PFRYMDT; -.
DR   OrthoDB; 977512at2; -.
DR   BioCyc; BXEN266265:BXE_RS38080-MONOMER; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000001817; Chromosome 3.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
DR   PROSITE; PS00067; 3HCDH; 1.
PE   4: Predicted;
DR   PRODOM; Q13I86.
DR   SWISS-2DPAGE; Q13I86.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001817};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00324627,
KW   ECO:0000313|EMBL:ABE36203.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001817}.
FT   DOMAIN      316    493       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      496    595       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   714 AA;  75807 MW;  5FFC4634ACE982F4 CRC64;
     MVTTHTEGPI GHLVIDVPGR SMNVLDPELA HALDEALTRL VDDEAVRGIV ISSGKSSFVA
     GADLARMSDF VKPGVSQADA LGLIGLYNRL LRRIETCGKP VVAAASGTAL GGGLELMLCA
     HYRIATDDPK ARFGLPEVGL GLLPGAGGTQ RLPRLIGIAA SLPLLTQGTS LDARAALKLG
     ILNEVVPAGE LIQAASRALL EGRVKAIAPW DEKGFRLPGG DAYSRVNSDA LMAANASLHA
     ATKGNYPAPQ AILRAVYEGT RLPIDKGLKL EQQLFVKLVQ GAVAQNMIRT LFFARQAADK
     LSRRPAGIAK QSVRRLGIVG AGFMGAGIAQ VSAAAGIDVV LLDRDLATAG RGRDSIAKAL
     QAEVDKGRLR EAVRDQILSR IEVAADHSAF GNCDLVIEAV LEDFEVKASV TRATEAALPA
     HAIFASNTSA LPINELASAS ARPQNFIGLH FFSPVSRMAL VEVIVGSATS DETLARSLDY
     IQQIHKTPIV VRDGYGFYTT RCVEAYIREG VRLLADGVNP VLIENAGTAL GMPVGPLTLA
     DEVGIDVLHH IVSLFRDREH GRWADDKHGA GNAILGRLEL AGRFGRKAGR GFFAYPPGEP
     RHLELGDLDL SVAADQPEVG QVKERLLYAQ VLEAARCWTD GVIDDAREAD LGAHLGWAFP
     SWLGGPLAFI DTVGITNFVQ RSDELVARYG PRFEVPGRLR EAAAGGQRFH AVAA
//

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