(data stored in ACNUC7421 zone)

SWISSPROT: CCMA_PARXL

ID   CCMA_PARXL              Reviewed;         228 AA.
AC   Q13I12;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   11-DEC-2019, entry version 96.
DE   RecName: Full=Cytochrome c biogenesis ATP-binding export protein CcmA {ECO:0000255|HAMAP-Rule:MF_01707};
DE            EC=7.6.2.5 {ECO:0000255|HAMAP-Rule:MF_01707};
DE   AltName: Full=Heme exporter protein A {ECO:0000255|HAMAP-Rule:MF_01707};
GN   Name=ccmA {ECO:0000255|HAMAP-Rule:MF_01707}; OrderedLocusNames=Bxeno_C0349;
GN   ORFNames=Bxe_C0370;
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400;
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M., Lao V.,
RA   Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A., Marx C.J.,
RA   Parnell J.J., Ramette A., Richardson P., Seeger M., Smith D., Spilker T.,
RA   Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B., Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome
RT   shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- FUNCTION: Part of the ABC transporter complex CcmAB involved in the
CC       biogenesis of c-type cytochromes; once thought to export heme, this
CC       seems not to be the case, but its exact role is uncertain. Responsible
CC       for energy coupling to the transport system. {ECO:0000255|HAMAP-
CC       Rule:MF_01707}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate;
CC         Xref=Rhea:RHEA:19261, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:60344,
CC         ChEBI:CHEBI:456216; EC=7.6.2.5; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01707};
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (CcmA) and
CC       two transmembrane proteins (CcmB). {ECO:0000255|HAMAP-Rule:MF_01707}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01707}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01707}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. CcmA exporter
CC       (TC 3.A.1.107) family. {ECO:0000255|HAMAP-Rule:MF_01707}.
DR   EMBL; CP000272; ABE36277.1; -; Genomic_DNA.
DR   RefSeq; WP_011493537.1; NZ_CP008761.1.
DR   SMR; Q13I12; -.
DR   STRING; 266265.Bxe_C0370; -.
DR   EnsemblBacteria; ABE36277; ABE36277; Bxe_C0370.
DR   GeneID; 4009884; -.
DR   KEGG; bxb:DR64_8071; -.
DR   KEGG; bxe:Bxe_C0370; -.
DR   PATRIC; fig|266265.5.peg.8139; -.
DR   eggNOG; ENOG4107EV4; Bacteria.
DR   eggNOG; COG4133; LUCA.
DR   KO; K02193; -.
DR   OMA; WNGADIH; -.
DR   OrthoDB; 1833499at2; -.
DR   BioCyc; BXEN266265:BXE_RS38435-MONOMER; -.
DR   Proteomes; UP000001817; Chromosome 3.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATPase activity; IEA:InterPro.
DR   GO; GO:0015439; F:ATPase-coupled heme transmembrane transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like.
DR   InterPro; IPR017871; ABC_transporter_CS.
DR   InterPro; IPR005895; ABC_transptr_haem_export_CcmA.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR43499; PTHR43499; 2.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01189; ccmA; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR   PROSITE; PS51243; CCMA; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q13I12.
DR   SWISS-2DPAGE; Q13I12.
KW   ATP-binding; Cell inner membrane; Cell membrane;
KW   Cytochrome c-type biogenesis; Membrane; Nucleotide-binding;
KW   Reference proteome; Translocase; Transport.
FT   CHAIN           1..228
FT                   /note="Cytochrome c biogenesis ATP-binding export protein
FT                   CcmA"
FT                   /id="PRO_0000271919"
FT   DOMAIN          2..227
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01707"
FT   NP_BIND         34..41
FT                   /note="ATP"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01707"
SQ   SEQUENCE   228 AA;  24182 MW;  D1C06EA6DB0026F0 CRC64;
     MLSIERLGVG RGGQMVASGI DLCIEAGWAL QIHGANGSGK TTLLRVLAGL MPPAGGQVSW
     YGANVRAHPE KFRRDLAFVG HANGVNDDLT VLENLRFATL LGAGSGAPDG TSSVPASGRS
     GVAAPPSRRD MLARAGMLPL QHTRAGCLSQ GQRRRVALAR LMLDRKPLWL LDEPGDALDD
     SASGWLHECL ALHMQDGGIV VATTHRSLQT PAARTRHLHL ERSGAWLD
//

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