(data stored in ACNUC7421 zone)

SWISSPROT: Q13HU3_PARXL

ID   Q13HU3_PARXL            Unreviewed;       134 AA.
AC   Q13HU3;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   08-MAY-2019, entry version 82.
DE   RecName: Full=Ribonuclease VapC {ECO:0000256|HAMAP-Rule:MF_00265};
DE            Short=RNase VapC {ECO:0000256|HAMAP-Rule:MF_00265};
DE            EC=3.1.-.- {ECO:0000256|HAMAP-Rule:MF_00265};
DE   AltName: Full=Toxin VapC {ECO:0000256|HAMAP-Rule:MF_00265};
GN   Name=vapC {ECO:0000256|HAMAP-Rule:MF_00265};
GN   ORFNames=Bxe_C0442 {ECO:0000313|EMBL:ABE36346.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE36346.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE36346.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE36346.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- FUNCTION: Toxic component of a toxin-antitoxin (TA) system. An
CC       RNase. {ECO:0000256|HAMAP-Rule:MF_00265}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00265, ECO:0000256|SAAS:SAAS00608033};
CC   -!- SIMILARITY: Belongs to the PINc/VapC protein family.
CC       {ECO:0000256|HAMAP-Rule:MF_00265, ECO:0000256|SAAS:SAAS00541436}.
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DR   EMBL; CP000272; ABE36346.1; -; Genomic_DNA.
DR   RefSeq; WP_011493602.1; NZ_CP008761.1.
DR   STRING; 266265.Bxe_C0442; -.
DR   EnsemblBacteria; ABE36346; ABE36346; Bxe_C0442.
DR   GeneID; 4009956; -.
DR   KEGG; bxb:DR64_8001; -.
DR   KEGG; bxe:Bxe_C0442; -.
DR   PATRIC; fig|266265.5.peg.8205; -.
DR   eggNOG; ENOG4108IGI; Bacteria.
DR   eggNOG; ENOG4111JC8; LUCA.
DR   HOGENOM; HOG000121274; -.
DR   KO; K18828; -.
DR   OMA; NTAEFTR; -.
DR   OrthoDB; 1968541at2; -.
DR   BioCyc; BXEN266265:BXE_RS38775-MONOMER; -.
DR   Proteomes; UP000001817; Chromosome 3.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004540; F:ribonuclease activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   HAMAP; MF_00265; VapC_Nob1; 1.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR002716; PIN_dom.
DR   InterPro; IPR022907; VapC_family.
DR   Pfam; PF01850; PIN; 1.
DR   SMART; SM00670; PINc; 1.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q13HU3.
DR   SWISS-2DPAGE; Q13HU3.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001817};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00265,
KW   ECO:0000256|SAAS:SAAS00423921};
KW   Magnesium {ECO:0000256|HAMAP-Rule:MF_00265,
KW   ECO:0000256|SAAS:SAAS00541414};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00265,
KW   ECO:0000256|SAAS:SAAS00423897};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_00265,
KW   ECO:0000256|SAAS:SAAS00423900};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001817};
KW   Toxin {ECO:0000256|HAMAP-Rule:MF_00265};
KW   Toxin-antitoxin system {ECO:0000256|HAMAP-Rule:MF_00265,
KW   ECO:0000256|SAAS:SAAS00986330}.
FT   DOMAIN        2    121       PINc. {ECO:0000259|SMART:SM00670}.
FT   METAL         7      7       Magnesium. {ECO:0000256|HAMAP-Rule:
FT                                MF_00265}.
FT   METAL        98     98       Magnesium. {ECO:0000256|HAMAP-Rule:
FT                                MF_00265}.
SQ   SEQUENCE   134 AA;  14409 MW;  B613BD43E6B094EE CRC64;
     MSGYLLDTNI ISDMIRNPFG QVAARIEQID PRAICTSVVV AAELRYGCAK KGSAKLLARV
     ESLLATIPVL PLDVPADTEY GGIRAELEAA GQPIGANDLL IGAHAYALGL TLVTDNTKEF
     SRIRGLTIEN WLDR
//

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