(data stored in ACNUC7421 zone)

SWISSPROT: Q13HR8_PARXL

ID   Q13HR8_PARXL            Unreviewed;       149 AA.
AC   Q13HR8;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   08-MAY-2019, entry version 88.
DE   RecName: Full=Cyanate hydratase {ECO:0000256|HAMAP-Rule:MF_00535};
DE            Short=Cyanase {ECO:0000256|HAMAP-Rule:MF_00535};
DE            EC=4.2.1.104 {ECO:0000256|HAMAP-Rule:MF_00535};
DE   AltName: Full=Cyanate hydrolase {ECO:0000256|HAMAP-Rule:MF_00535};
DE   AltName: Full=Cyanate lyase {ECO:0000256|HAMAP-Rule:MF_00535};
GN   Name=cynS {ECO:0000256|HAMAP-Rule:MF_00535};
GN   ORFNames=Bxe_C0467 {ECO:0000313|EMBL:ABE36371.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE36371.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE36371.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE36371.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- FUNCTION: Catalyzes the reaction of cyanate with bicarbonate to
CC       produce ammonia and carbon dioxide. {ECO:0000256|HAMAP-
CC       Rule:MF_00535}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=cyanate + 3 H(+) + hydrogencarbonate = 2 CO2 + NH4(+);
CC         Xref=Rhea:RHEA:11120, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:17544, ChEBI:CHEBI:28938, ChEBI:CHEBI:29195;
CC         EC=4.2.1.104; Evidence={ECO:0000256|HAMAP-Rule:MF_00535};
CC   -!- SIMILARITY: Belongs to the cyanase family. {ECO:0000256|HAMAP-
CC       Rule:MF_00535}.
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DR   EMBL; CP000272; ABE36371.1; -; Genomic_DNA.
DR   RefSeq; WP_011493627.1; NZ_CP008761.1.
DR   STRING; 266265.Bxe_C0467; -.
DR   EnsemblBacteria; ABE36371; ABE36371; Bxe_C0467.
DR   GeneID; 4009981; -.
DR   KEGG; bxb:DR64_7976; -.
DR   KEGG; bxe:Bxe_C0467; -.
DR   PATRIC; fig|266265.5.peg.8231; -.
DR   eggNOG; ENOG4108V7B; Bacteria.
DR   eggNOG; COG1513; LUCA.
DR   HOGENOM; HOG000043436; -.
DR   KO; K01725; -.
DR   OMA; ITMSGKF; -.
DR   OrthoDB; 1506439at2; -.
DR   BioCyc; BXEN266265:BXE_RS38895-MONOMER; -.
DR   Proteomes; UP000001817; Chromosome 3.
DR   GO; GO:0008824; F:cyanate hydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0009439; P:cyanate metabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00559; Cyanase_C; 1.
DR   Gene3D; 3.30.1160.10; -; 1.
DR   HAMAP; MF_00535; Cyanate_hydrat; 1.
DR   InterPro; IPR008076; Cyanase.
DR   InterPro; IPR003712; Cyanate_lyase_C.
DR   InterPro; IPR036581; Cyanate_lyase_C_sf.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   PANTHER; PTHR34186; PTHR34186; 1.
DR   Pfam; PF02560; Cyanate_lyase; 1.
DR   PIRSF; PIRSF001263; Cyanate_hydratas; 1.
DR   PRINTS; PR01693; CYANASE.
DR   SMART; SM01116; Cyanate_lyase; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF55234; SSF55234; 1.
DR   TIGRFAMs; TIGR00673; cynS; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q13HR8.
DR   SWISS-2DPAGE; Q13HR8.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001817};
KW   Lyase {ECO:0000256|HAMAP-Rule:MF_00535, ECO:0000313|EMBL:ABE36371.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001817}.
FT   DOMAIN       77    149       Cyanate_lyase. {ECO:0000259|SMART:
FT                                SM01116}.
FT   ACT_SITE     90     90       {ECO:0000256|HAMAP-Rule:MF_00535}.
FT   ACT_SITE     93     93       {ECO:0000256|HAMAP-Rule:MF_00535}.
FT   ACT_SITE    116    116       {ECO:0000256|HAMAP-Rule:MF_00535}.
SQ   SEQUENCE   149 AA;  16694 MW;  CC471359E70E36ED CRC64;
     MISSRNEVTE MIVAAKVAKG ITWADVATKV GFSKEWTTAA CLGQMTLDEQ QAKVVGDIFG
     LPEDAVRWLQ VVPYKGALPT AVPTDPLIYR WYEVVSVYDS TMKELIHEEF GDGIMSAIDF
     SMDIQREPDP KGDRVRVVLS GKFLTYETW
//

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