(data stored in ACNUC7421 zone)

SWISSPROT: Q13HE4_PARXL

ID   Q13HE4_PARXL            Unreviewed;       394 AA.
AC   Q13HE4;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   08-MAY-2019, entry version 80.
DE   SubName: Full=Thiolase {ECO:0000313|EMBL:ABE36495.1};
DE            EC=2.3.1.16 {ECO:0000313|EMBL:ABE36495.1};
GN   ORFNames=Bxe_C0597 {ECO:0000313|EMBL:ABE36495.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE36495.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE36495.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE36495.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- SIMILARITY: Belongs to the thiolase family.
CC       {ECO:0000256|RuleBase:RU003557}.
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DR   EMBL; CP000272; ABE36495.1; -; Genomic_DNA.
DR   RefSeq; WP_011493751.1; NZ_CP008761.1.
DR   STRING; 266265.Bxe_C0597; -.
DR   EnsemblBacteria; ABE36495; ABE36495; Bxe_C0597.
DR   GeneID; 4010111; -.
DR   KEGG; bxb:DR64_7849; -.
DR   KEGG; bxe:Bxe_C0597; -.
DR   PATRIC; fig|266265.5.peg.8358; -.
DR   eggNOG; ENOG4105CHU; Bacteria.
DR   eggNOG; COG0183; LUCA.
DR   HOGENOM; HOG000012239; -.
DR   KO; K00632; -.
DR   OMA; WHITPGN; -.
DR   OrthoDB; 550338at2; -.
DR   BioCyc; BXEN266265:BXE_RS39500-MONOMER; -.
DR   Proteomes; UP000001817; Chromosome 3.
DR   GO; GO:0003988; F:acetyl-CoA C-acyltransferase activity; IEA:UniProtKB-EC.
DR   CDD; cd00751; thiolase; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR002155; Thiolase.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR020617; Thiolase_C.
DR   InterPro; IPR020613; Thiolase_CS.
DR   InterPro; IPR020616; Thiolase_N.
DR   Pfam; PF02803; Thiolase_C; 1.
DR   Pfam; PF00108; Thiolase_N; 1.
DR   PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   TIGRFAMs; TIGR01930; AcCoA-C-Actrans; 1.
DR   PROSITE; PS00737; THIOLASE_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q13HE4.
DR   SWISS-2DPAGE; Q13HE4.
KW   Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW   ECO:0000313|EMBL:ABE36495.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001817};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001817};
KW   Transferase {ECO:0000256|RuleBase:RU003557,
KW   ECO:0000313|EMBL:ABE36495.1}.
FT   DOMAIN        8    262       Thiolase_N. {ECO:0000259|Pfam:PF00108}.
FT   DOMAIN      271    392       Thiolase_C. {ECO:0000259|Pfam:PF02803}.
FT   ACT_SITE     93     93       Acyl-thioester intermediate.
FT                                {ECO:0000256|PIRSR:PIRSR000429-1}.
FT   ACT_SITE    349    349       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000429-1}.
FT   ACT_SITE    379    379       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000429-1}.
SQ   SEQUENCE   394 AA;  41378 MW;  9C37F065AAA76D53 CRC64;
     MTRDTRDVVI VDAVRTPIGK FRGALAGVRA DHLGALVIDE LIRRAGVKPQ AVNDVVFGCV
     TQIGEQSANI ARTSVLGAGW PETIPGLTID RKCGSGEEAV HIAAGLIAFG AADVIVAGGA
     ESMSRVPMGS NRDLHGEAFG WMASERFELT SQGEAAERLC DCWALTRAQL DAYSVESHRR
     AAAAAAEGWF AREIVPVPVG QVREKSLEGE AALFAADETI RPGTNADKLA TLKSSFRSDG
     RLTAGNSSQI SDGAAALLLM SSDKARELGV KARARVRAVT TVGSDPTLML TGPILATCQV
     LEKAGLGLSD IDLFEINEAF APVPLVWMKE FGVPHAKLNV NGGAIALGHP LGASGARIMT
     SMLHELERRG ARYGLQAICC AGGMGTATLI ERLD
//

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