(data stored in ACNUC7421 zone)

SWISSPROT: TRPA_RHOPS

ID   TRPA_RHOPS              Reviewed;         278 AA.
AC   Q13EQ1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   08-MAY-2019, entry version 74.
DE   RecName: Full=Tryptophan synthase alpha chain {ECO:0000255|HAMAP-Rule:MF_00131};
DE            EC=4.2.1.20 {ECO:0000255|HAMAP-Rule:MF_00131};
GN   Name=trpA {ECO:0000255|HAMAP-Rule:MF_00131};
GN   OrderedLocusNames=RPD_0198;
OS   Rhodopseudomonas palustris (strain BisB5).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Bradyrhizobiaceae; Rhodopseudomonas.
OX   NCBI_TaxID=316057;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BisB5;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Pelletier D.A., Kyrpides N.,
RA   Lykidis A., Oda Y., Harwood C.S., Richardson P.;
RT   "Complete sequence of Rhodopseudomonas palustris BisB5.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The alpha subunit is responsible for the aldol cleavage
CC       of indoleglycerol phosphate to indole and glyceraldehyde 3-
CC       phosphate. {ECO:0000255|HAMAP-Rule:MF_00131}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine =
CC         D-glyceraldehyde 3-phosphate + H2O + L-tryptophan;
CC         Xref=Rhea:RHEA:10532, ChEBI:CHEBI:15377, ChEBI:CHEBI:33384,
CC         ChEBI:CHEBI:57912, ChEBI:CHEBI:58866, ChEBI:CHEBI:59776;
CC         EC=4.2.1.20; Evidence={ECO:0000255|HAMAP-Rule:MF_00131};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 5/5. {ECO:0000255|HAMAP-
CC       Rule:MF_00131}.
CC   -!- SUBUNIT: Tetramer of two alpha and two beta chains.
CC       {ECO:0000255|HAMAP-Rule:MF_00131}.
CC   -!- SIMILARITY: Belongs to the TrpA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00131}.
DR   EMBL; CP000283; ABE37438.1; -; Genomic_DNA.
DR   RefSeq; WP_011500630.1; NC_007958.1.
DR   SMR; Q13EQ1; -.
DR   STRING; 316057.RPD_0198; -.
DR   EnsemblBacteria; ABE37438; ABE37438; RPD_0198.
DR   KEGG; rpd:RPD_0198; -.
DR   eggNOG; ENOG4105F6H; Bacteria.
DR   eggNOG; COG0159; LUCA.
DR   HOGENOM; HOG000223815; -.
DR   KO; K01695; -.
DR   OMA; DYPPEEC; -.
DR   OrthoDB; 912786at2; -.
DR   BioCyc; RPAL316057:RPD_RS01005-MONOMER; -.
DR   UniPathway; UPA00035; UER00044.
DR   Proteomes; UP000001818; Chromosome.
DR   GO; GO:0004834; F:tryptophan synthase activity; IEA:UniProtKB-UniRule.
DR   CDD; cd04724; Tryptophan_synthase_alpha; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00131; Trp_synth_alpha; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   InterPro; IPR018204; Trp_synthase_alpha_AS.
DR   InterPro; IPR002028; Trp_synthase_suA.
DR   Pfam; PF00290; Trp_syntA; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   TIGRFAMs; TIGR00262; trpA; 1.
DR   PROSITE; PS00167; TRP_SYNTHASE_ALPHA; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q13EQ1.
DR   SWISS-2DPAGE; Q13EQ1.
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Lyase; Tryptophan biosynthesis.
FT   CHAIN         1    278       Tryptophan synthase alpha chain.
FT                                /FTId=PRO_1000018270.
FT   ACT_SITE     50     50       Proton acceptor. {ECO:0000255|HAMAP-
FT                                Rule:MF_00131}.
FT   ACT_SITE     61     61       Proton acceptor. {ECO:0000255|HAMAP-
FT                                Rule:MF_00131}.
SQ   SEQUENCE   278 AA;  28747 MW;  349C774C91F7746D CRC64;
     MTTRIDTRFA ELKKQGRSAF VTFVMAGDPD LATSLQVLKA LPAAGADIIE IGMPFTDPMA
     DGPAIQAAGL RALHSGATLS HTLGLVRDFR KDDDTTPMVL MGYYNPIYIY GVDAFLADAK
     AAGVDGLIIV DLPPEEDSEL CLPAMKAGLN FIRLATPTTD EKRLPAVLAN TSGFVYYVSI
     TGITGSASAD SAAVGDAVAR IKRHTDLPVC VGFGIRTPEA ARAIAAEADG AVVGSALIDA
     LQKSLDADNR ATKATVGAVA DLVASLAAGV RGAKQAAE
//

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